Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965076080> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2965076080 endingPage "16176" @default.
- W2965076080 startingPage "16175" @default.
- W2965076080 abstract "Hyperchloremic metabolic acidosis along with hypertension and hyperkalemia are features of pseudohypoaldosteronism type II (PHAII). Increased activity of sodium chloride cotransporter (NCC) is believed to be an important mechanism of these phenotypic features (1). Gain-of-function mutations of WNK4 in PHAII activate NCC in the distal convoluted tubule, which leads to enhanced sodium and chloride reabsorption causing hypertension and diminished sodium delivery to the downstream cortical collecting duct, resulting in hyperkalemia. Our recent report (2) that chloride-insensitive WNK4 knockin mouse exhibits increased WNK4 kinase activity and fully recapitulates PHAII phenotype supports the notion. Still, as mentioned by Farfel et al. (3), there remain debates on the … [↵][1]1To whom correspondence may be addressed. Email: laurence1234kimo{at}yahoo.com.tw. [1]: #xref-corresp-1-1" @default.
- W2965076080 created "2019-08-13" @default.
- W2965076080 creator A5000123938 @default.
- W2965076080 creator A5034595977 @default.
- W2965076080 creator A5062825293 @default.
- W2965076080 creator A5080225643 @default.
- W2965076080 date "2019-08-01" @default.
- W2965076080 modified "2023-10-18" @default.
- W2965076080 title "Reply to Farfel et al.: Is enhanced chloride reabsorption in proximal tubule a possible mechanism of metabolic acidosis in PHAII?" @default.
- W2965076080 cites W1994348186 @default.
- W2965076080 cites W2008731758 @default.
- W2965076080 cites W2018457137 @default.
- W2965076080 cites W2053007448 @default.
- W2965076080 cites W2161863622 @default.
- W2965076080 cites W2165835843 @default.
- W2965076080 cites W2788915784 @default.
- W2965076080 cites W2842319585 @default.
- W2965076080 cites W2914915930 @default.
- W2965076080 cites W2965939947 @default.
- W2965076080 cites W4235533348 @default.
- W2965076080 doi "https://doi.org/10.1073/pnas.1910215116" @default.
- W2965076080 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6697869" @default.
- W2965076080 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31371516" @default.
- W2965076080 hasPublicationYear "2019" @default.
- W2965076080 type Work @default.
- W2965076080 sameAs 2965076080 @default.
- W2965076080 citedByCount "0" @default.
- W2965076080 crossrefType "journal-article" @default.
- W2965076080 hasAuthorship W2965076080A5000123938 @default.
- W2965076080 hasAuthorship W2965076080A5034595977 @default.
- W2965076080 hasAuthorship W2965076080A5062825293 @default.
- W2965076080 hasAuthorship W2965076080A5080225643 @default.
- W2965076080 hasBestOaLocation W29650760801 @default.
- W2965076080 hasConcept C121332964 @default.
- W2965076080 hasConcept C126322002 @default.
- W2965076080 hasConcept C134018914 @default.
- W2965076080 hasConcept C185592680 @default.
- W2965076080 hasConcept C2778553927 @default.
- W2965076080 hasConcept C2779246250 @default.
- W2965076080 hasConcept C2780091579 @default.
- W2965076080 hasConcept C2780222010 @default.
- W2965076080 hasConcept C2780498532 @default.
- W2965076080 hasConcept C2909587778 @default.
- W2965076080 hasConcept C3018884230 @default.
- W2965076080 hasConcept C55493867 @default.
- W2965076080 hasConcept C56906281 @default.
- W2965076080 hasConcept C62520636 @default.
- W2965076080 hasConcept C71924100 @default.
- W2965076080 hasConcept C89611455 @default.
- W2965076080 hasConceptScore W2965076080C121332964 @default.
- W2965076080 hasConceptScore W2965076080C126322002 @default.
- W2965076080 hasConceptScore W2965076080C134018914 @default.
- W2965076080 hasConceptScore W2965076080C185592680 @default.
- W2965076080 hasConceptScore W2965076080C2778553927 @default.
- W2965076080 hasConceptScore W2965076080C2779246250 @default.
- W2965076080 hasConceptScore W2965076080C2780091579 @default.
- W2965076080 hasConceptScore W2965076080C2780222010 @default.
- W2965076080 hasConceptScore W2965076080C2780498532 @default.
- W2965076080 hasConceptScore W2965076080C2909587778 @default.
- W2965076080 hasConceptScore W2965076080C3018884230 @default.
- W2965076080 hasConceptScore W2965076080C55493867 @default.
- W2965076080 hasConceptScore W2965076080C56906281 @default.
- W2965076080 hasConceptScore W2965076080C62520636 @default.
- W2965076080 hasConceptScore W2965076080C71924100 @default.
- W2965076080 hasConceptScore W2965076080C89611455 @default.
- W2965076080 hasFunder F4320322795 @default.
- W2965076080 hasIssue "33" @default.
- W2965076080 hasLocation W29650760801 @default.
- W2965076080 hasLocation W29650760802 @default.
- W2965076080 hasLocation W29650760803 @default.
- W2965076080 hasLocation W29650760804 @default.
- W2965076080 hasOpenAccess W2965076080 @default.
- W2965076080 hasPrimaryLocation W29650760801 @default.
- W2965076080 hasRelatedWork W196172363 @default.
- W2965076080 hasRelatedWork W2354619083 @default.
- W2965076080 hasRelatedWork W2402082911 @default.
- W2965076080 hasRelatedWork W2416079795 @default.
- W2965076080 hasRelatedWork W2436895521 @default.
- W2965076080 hasRelatedWork W2437419362 @default.
- W2965076080 hasRelatedWork W2471573469 @default.
- W2965076080 hasRelatedWork W2965076080 @default.
- W2965076080 hasRelatedWork W35581403 @default.
- W2965076080 hasRelatedWork W994497504 @default.
- W2965076080 hasVolume "116" @default.
- W2965076080 isParatext "false" @default.
- W2965076080 isRetracted "false" @default.
- W2965076080 magId "2965076080" @default.
- W2965076080 workType "article" @default.