FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965106829> ?p ?o ?g. }

• W2965106829 endingPage "2570" @default.
• W2965106829 startingPage "2565" @default.
• W2965106829 abstract "We describe the design, synthesis, and biological evaluation of novel HIV-1 protease inhibitors containing a squaramide-derived scaffold as the P2 ligand in combination with a (R)-hydroxyethylamine sulfonamide isostere. Inhibitor 3h with an N-methyl-3-(R)-aminotetrahydrofuranyl squaramide P2-ligand displayed an HIV-1 protease inhibitory Ki value of 0.51 nM. An energy minimized model of 3h revealed the major molecular interactions between HIV-1 protease active site and the tetrahydrofuranyl squaramide scaffold that may be responsible for its potent activity." @default.
• W2965106829 created "2019-08-13" @default.
• W2965106829 creator A5004168302 @default.
• W2965106829 creator A5009567252 @default.
• W2965106829 creator A5022281589 @default.
• W2965106829 creator A5032049756 @default.
• W2965106829 creator A5034448543 @default.
• W2965106829 creator A5041773055 @default.
• W2965106829 creator A5056776173 @default.
• W2965106829 creator A5061687318 @default.
• W2965106829 creator A5071299834 @default.
• W2965106829 date "2019-09-01" @default.
• W2965106829 modified "2023-10-11" @default.
• W2965106829 title "Potent HIV-1 protease inhibitors incorporating squaramide-derived P2 ligands: Design, synthesis, and biological evaluation" @default.
• W2965106829 cites W1550129999 @default.
• W2965106829 cites W1980089016 @default.
• W2965106829 cites W1986986717 @default.
• W2965106829 cites W1991696252 @default.
• W2965106829 cites W1999018540 @default.
• W2965106829 cites W2010751579 @default.
• W2965106829 cites W2022961751 @default.
• W2965106829 cites W2023770186 @default.
• W2965106829 cites W2024050097 @default.
• W2965106829 cites W2025634036 @default.
• W2965106829 cites W2028344920 @default.
• W2965106829 cites W2031040219 @default.
• W2965106829 cites W2044581646 @default.
• W2965106829 cites W2069388608 @default.
• W2965106829 cites W2073036247 @default.
• W2965106829 cites W2077885301 @default.
• W2965106829 cites W2086182182 @default.
• W2965106829 cites W2089382521 @default.
• W2965106829 cites W2093751313 @default.
• W2965106829 cites W2110533836 @default.
• W2965106829 cites W2115405122 @default.
• W2965106829 cites W2119751130 @default.
• W2965106829 cites W2140763734 @default.
• W2965106829 cites W2147421370 @default.
• W2965106829 cites W2151979023 @default.
• W2965106829 cites W2152293013 @default.
• W2965106829 cites W2152505869 @default.
• W2965106829 cites W2153868685 @default.
• W2965106829 cites W2270189214 @default.
• W2965106829 cites W2345988829 @default.
• W2965106829 cites W2793279239 @default.
• W2965106829 cites W2952919357 @default.
• W2965106829 doi "https://doi.org/10.1016/j.bmcl.2019.08.006" @default.
• W2965106829 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6711809" @default.
• W2965106829 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31416666" @default.
• W2965106829 hasPublicationYear "2019" @default.
• W2965106829 type Work @default.
• W2965106829 sameAs 2965106829 @default.
• W2965106829 citedByCount "8" @default.
• W2965106829 countsByYear W29651068292020 @default.
• W2965106829 countsByYear W29651068292021 @default.
• W2965106829 countsByYear W29651068292023 @default.
• W2965106829 crossrefType "journal-article" @default.
• W2965106829 hasAuthorship W2965106829A5004168302 @default.
• W2965106829 hasAuthorship W2965106829A5009567252 @default.
• W2965106829 hasAuthorship W2965106829A5022281589 @default.
• W2965106829 hasAuthorship W2965106829A5032049756 @default.
• W2965106829 hasAuthorship W2965106829A5034448543 @default.
• W2965106829 hasAuthorship W2965106829A5041773055 @default.
• W2965106829 hasAuthorship W2965106829A5056776173 @default.
• W2965106829 hasAuthorship W2965106829A5061687318 @default.
• W2965106829 hasAuthorship W2965106829A5071299834 @default.
• W2965106829 hasBestOaLocation W29651068292 @default.
• W2965106829 hasConcept C116569031 @default.
• W2965106829 hasConcept C142462285 @default.
• W2965106829 hasConcept C146686406 @default.
• W2965106829 hasConcept C159047783 @default.
• W2965106829 hasConcept C161790260 @default.
• W2965106829 hasConcept C170493617 @default.
• W2965106829 hasConcept C181199279 @default.
• W2965106829 hasConcept C185592680 @default.
• W2965106829 hasConcept C21951064 @default.
• W2965106829 hasConcept C2776700668 @default.
• W2965106829 hasConcept C2776714187 @default.
• W2965106829 hasConcept C2777583353 @default.
• W2965106829 hasConcept C2781039511 @default.
• W2965106829 hasConcept C2781143361 @default.
• W2965106829 hasConcept C2993143319 @default.
• W2965106829 hasConcept C3013748606 @default.
• W2965106829 hasConcept C55493867 @default.
• W2965106829 hasConcept C66972969 @default.
• W2965106829 hasConcept C71240020 @default.
• W2965106829 hasConcept C86803240 @default.
• W2965106829 hasConceptScore W2965106829C116569031 @default.
• W2965106829 hasConceptScore W2965106829C142462285 @default.
• W2965106829 hasConceptScore W2965106829C146686406 @default.
• W2965106829 hasConceptScore W2965106829C159047783 @default.
• W2965106829 hasConceptScore W2965106829C161790260 @default.
• W2965106829 hasConceptScore W2965106829C170493617 @default.
• W2965106829 hasConceptScore W2965106829C181199279 @default.
• W2965106829 hasConceptScore W2965106829C185592680 @default.
• W2965106829 hasConceptScore W2965106829C21951064 @default.
• W2965106829 hasConceptScore W2965106829C2776700668 @default.
• W2965106829 hasConceptScore W2965106829C2776714187 @default.

• next