Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965150487> ?p ?o ?g. }
Showing items 1 to 75 of
75
with 100 items per page.
- W2965150487 endingPage "S1301" @default.
- W2965150487 startingPage "S1301" @default.
- W2965150487 abstract "Bulbus Fritillaria cirrhosa D. Don (BFC) has been used in China as a folk medicine for the treatment of cough and asthma for more than 2000 years. The antitussive and antiasthmatic effects of BFC have been reported before, nevertheless its toxicity and safety have not been documented. This study investigated the possible effects of BFC on spindle assembly checkpoint (SAC), mitotic fidelity and genomic stability in human NCM460 colon epithelial cells.Cells were treated with BFC (0, 20, 40, 80 and 160 μg/ml) for 24, 48 and 72 h and harvested differently according to the biomarkers observed. Mitotic aberrations were assessed by the biomarkers of chromosome misalignment (CMA), chromosome lagging (CL) and chromatin bridge (CB). Frequencies of micronuclei (MN), nucleoplasmic bridge and nuclear bud (NB) in cytokinesis-block micronucleus assay were used as indicators of genomic instability (GIN). SAC activity was determined by anaphase to metaphase ratio (AMR) and the expression of several SAC genes, including CENP-E, Mps1, Bub1, Mad-1, BubR1 and Mad-2.Compared with the control, cells in BFC treated groups (80 and 160 μg/ml) showed: 1) increased AMR (p < 0.05), up-regulated expression of Mps1, Bub1 and Mad-1 (p < 0.05) and down-regulated expression of CENP-E, BubR1 and Mad-2 (p < 0.05); 2) increased frequencies of CMA, CL and CB (p < 0.01); 3) increased incidences of MN and NB (p < 0.01).This study revealed for the first time that BFC causes mitotic aberrations and GIN in human colon epithelial cells and these effects maybe the result of SAC dysfunction." @default.
- W2965150487 created "2019-08-13" @default.
- W2965150487 creator A5028287374 @default.
- W2965150487 creator A5039230384 @default.
- W2965150487 creator A5039892564 @default.
- W2965150487 creator A5076680425 @default.
- W2965150487 creator A5085518986 @default.
- W2965150487 date "2019-01-01" @default.
- W2965150487 modified "2023-09-25" @default.
- W2965150487 title "SU63DNA METHYLOMIC PROFILING OF PREFRONTAL CORTEX SAMPLES FROM COMPLETED SUICIDE CASES" @default.
- W2965150487 doi "https://doi.org/10.1016/j.euroneuro.2018.08.427" @default.
- W2965150487 hasPublicationYear "2019" @default.
- W2965150487 type Work @default.
- W2965150487 sameAs 2965150487 @default.
- W2965150487 citedByCount "0" @default.
- W2965150487 crossrefType "journal-article" @default.
- W2965150487 hasAuthorship W2965150487A5028287374 @default.
- W2965150487 hasAuthorship W2965150487A5039230384 @default.
- W2965150487 hasAuthorship W2965150487A5039892564 @default.
- W2965150487 hasAuthorship W2965150487A5076680425 @default.
- W2965150487 hasAuthorship W2965150487A5085518986 @default.
- W2965150487 hasConcept C104317684 @default.
- W2965150487 hasConcept C126322002 @default.
- W2965150487 hasConcept C140752955 @default.
- W2965150487 hasConcept C153911025 @default.
- W2965150487 hasConcept C185592680 @default.
- W2965150487 hasConcept C2778354886 @default.
- W2965150487 hasConcept C2780391303 @default.
- W2965150487 hasConcept C29730261 @default.
- W2965150487 hasConcept C30481170 @default.
- W2965150487 hasConcept C36681516 @default.
- W2965150487 hasConcept C45080847 @default.
- W2965150487 hasConcept C54355233 @default.
- W2965150487 hasConcept C66640590 @default.
- W2965150487 hasConcept C70278784 @default.
- W2965150487 hasConcept C71924100 @default.
- W2965150487 hasConcept C86803240 @default.
- W2965150487 hasConcept C93304396 @default.
- W2965150487 hasConceptScore W2965150487C104317684 @default.
- W2965150487 hasConceptScore W2965150487C126322002 @default.
- W2965150487 hasConceptScore W2965150487C140752955 @default.
- W2965150487 hasConceptScore W2965150487C153911025 @default.
- W2965150487 hasConceptScore W2965150487C185592680 @default.
- W2965150487 hasConceptScore W2965150487C2778354886 @default.
- W2965150487 hasConceptScore W2965150487C2780391303 @default.
- W2965150487 hasConceptScore W2965150487C29730261 @default.
- W2965150487 hasConceptScore W2965150487C30481170 @default.
- W2965150487 hasConceptScore W2965150487C36681516 @default.
- W2965150487 hasConceptScore W2965150487C45080847 @default.
- W2965150487 hasConceptScore W2965150487C54355233 @default.
- W2965150487 hasConceptScore W2965150487C66640590 @default.
- W2965150487 hasConceptScore W2965150487C70278784 @default.
- W2965150487 hasConceptScore W2965150487C71924100 @default.
- W2965150487 hasConceptScore W2965150487C86803240 @default.
- W2965150487 hasConceptScore W2965150487C93304396 @default.
- W2965150487 hasLocation W29651504871 @default.
- W2965150487 hasOpenAccess W2965150487 @default.
- W2965150487 hasPrimaryLocation W29651504871 @default.
- W2965150487 hasRelatedWork W1836464961 @default.
- W2965150487 hasRelatedWork W2296510760 @default.
- W2965150487 hasRelatedWork W2359038038 @default.
- W2965150487 hasRelatedWork W2366914825 @default.
- W2965150487 hasRelatedWork W2380591561 @default.
- W2965150487 hasRelatedWork W2387479051 @default.
- W2965150487 hasRelatedWork W2565603608 @default.
- W2965150487 hasRelatedWork W2570176044 @default.
- W2965150487 hasRelatedWork W2793927130 @default.
- W2965150487 hasRelatedWork W3083066122 @default.
- W2965150487 hasVolume "29" @default.
- W2965150487 isParatext "false" @default.
- W2965150487 isRetracted "false" @default.
- W2965150487 magId "2965150487" @default.
- W2965150487 workType "article" @default.