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- W2965163995 abstract "Abstract Clinical data suggest that many malignant cancers are associated with hypercalcemia. Hypercalcemia can facilitate the proliferation and metastasis of gastric and colon tumors, and has been considered a hallmark of end-stage disease. However, it has also been reported that dietary calcium or vitamin D supplementation could reduce the risk of many types of cancers. In particular, the intestines can absorb considerable amounts of calcium via Ca2+-permeable ion channels, and hypercalcemia is common in patients with colorectal cancer. Thus, this review considers the role of calcium signaling in the context of colorectal cancer and summarizes the functions of specific regulators of cellular calcium levels in the proliferation, invasion, metastasis, cell death, and drug resistance of colorectal cancer cells. The data reveal that even a slight upregulation of intracellular Ca2+ signaling can facilitate the onset and progression of colorectal cancer, while continuous Ca2+ influx and Ca2+ overload may cause tumor cell death. This dual function of Ca2+ signaling adds nuance to the debate over the hallmarks of colorectal cancer, and may even provide new directions and strategies for clinical interventions." @default.
- W2965163995 created "2019-08-13" @default.
- W2965163995 creator A5000208395 @default.
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- W2965163995 creator A5066939607 @default.
- W2965163995 date "2019-11-01" @default.
- W2965163995 modified "2023-10-17" @default.
- W2965163995 title "A Complex Role for Calcium Signaling in Colorectal Cancer Development and Progression" @default.
- W2965163995 cites W1491042842 @default.
- W2965163995 cites W1522193348 @default.
- W2965163995 cites W1529565698 @default.
- W2965163995 cites W182409224 @default.
- W2965163995 cites W1874198797 @default.
- W2965163995 cites W1951756999 @default.
- W2965163995 cites W1968766433 @default.
- W2965163995 cites W1970840710 @default.
- W2965163995 cites W1970961751 @default.
- W2965163995 cites W1971342909 @default.
- W2965163995 cites W1973807205 @default.
- W2965163995 cites W1978593035 @default.
- W2965163995 cites W1982880390 @default.
- W2965163995 cites W1983034942 @default.
- W2965163995 cites W1986225368 @default.
- W2965163995 cites W2000429979 @default.
- W2965163995 cites W2000822564 @default.
- W2965163995 cites W2003197654 @default.
- W2965163995 cites W2005683137 @default.
- W2965163995 cites W2009888240 @default.
- W2965163995 cites W2010778412 @default.
- W2965163995 cites W2025748302 @default.
- W2965163995 cites W2027440191 @default.
- W2965163995 cites W2028452582 @default.
- W2965163995 cites W2028922188 @default.
- W2965163995 cites W2037335060 @default.
- W2965163995 cites W2047448341 @default.
- W2965163995 cites W2050852558 @default.
- W2965163995 cites W2056374730 @default.
- W2965163995 cites W2056985832 @default.
- W2965163995 cites W2058907296 @default.
- W2965163995 cites W2061967460 @default.
- W2965163995 cites W2062897287 @default.
- W2965163995 cites W2065133740 @default.
- W2965163995 cites W2070832223 @default.
- W2965163995 cites W2073059281 @default.
- W2965163995 cites W2073094322 @default.
- W2965163995 cites W2075214472 @default.
- W2965163995 cites W2077965603 @default.
- W2965163995 cites W2094291510 @default.
- W2965163995 cites W2101319242 @default.
- W2965163995 cites W2103403969 @default.
- W2965163995 cites W2104076248 @default.
- W2965163995 cites W2108995155 @default.
- W2965163995 cites W2109374824 @default.
- W2965163995 cites W2111083260 @default.
- W2965163995 cites W2114301011 @default.
- W2965163995 cites W2127950911 @default.
- W2965163995 cites W2131569767 @default.
- W2965163995 cites W2137258759 @default.
- W2965163995 cites W2148984020 @default.
- W2965163995 cites W2151260260 @default.
- W2965163995 cites W2163789582 @default.
- W2965163995 cites W2176487098 @default.
- W2965163995 cites W2276765123 @default.
- W2965163995 cites W2292468503 @default.
- W2965163995 cites W2322213171 @default.
- W2965163995 cites W2430021839 @default.
- W2965163995 cites W2499148618 @default.
- W2965163995 cites W2500421697 @default.
- W2965163995 cites W2509872933 @default.
- W2965163995 cites W2558667699 @default.
- W2965163995 cites W2559009215 @default.
- W2965163995 cites W2564563599 @default.
- W2965163995 cites W2566299136 @default.
- W2965163995 cites W2585029826 @default.
- W2965163995 cites W2607636199 @default.
- W2965163995 cites W2742984980 @default.
- W2965163995 cites W2751510358 @default.
- W2965163995 cites W2755158403 @default.
- W2965163995 cites W2765343422 @default.
- W2965163995 cites W2771031544 @default.
- W2965163995 cites W2789585495 @default.
- W2965163995 cites W2792349003 @default.
- W2965163995 cites W2794468278 @default.
- W2965163995 cites W2800777210 @default.
- W2965163995 cites W2801121970 @default.
- W2965163995 cites W2809389975 @default.
- W2965163995 cites W2892589092 @default.
- W2965163995 cites W2901644191 @default.
- W2965163995 cites W2904071554 @default.
- W2965163995 cites W2906176957 @default.