FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965176285> ?p ?o ?g. }

• W2965176285 endingPage "538" @default.
• W2965176285 startingPage "528" @default.
• W2965176285 abstract "Mg2+ homeostasis is essential for cell survival and the loss of this regulation has been associated with many neurodegenerative diseases, including loss of dopaminergic neurons. Although the neurotoxin-mediated loss of dopaminergic neurons in Parkinson disease models is extensively studied, the ion channel(s) that regulate Mg2+ homeostasis and thus could prevent neuronal cell death is not yet identified. Here, we show that TRPM7 (transient receptor potential melastatin 7) is involved in regulating Mg2+ homeostasis in dopaminergic cells. Importantly, transient loss of TRPM7 decreased intracellular Mg2+ levels and decreased dopaminergic cells/neurons survival. We provide further evidence that both increases in extracellular Mg2+ or transiently increasing TRPM7 levels protected dopaminergic SH-SY5Y cells against neurotoxin-mediated cell death. Neurotoxin treatment significantly decreased TRPM7 levels in both SH-SY5Y cells and the substantia nigra pars compacta region of mice, along with a decrease in Mg2+ influx. Moreover, Mg2+ supplementation showed a concentration-dependent decrease in caspase-3 activity, an increase in cell survival, restored mitochondrial membrane potential, and increase TRPM7 levels in neurotoxin-treated cells. In contrast, transient silencing of TRPM7 inhibited the positive effect of Mg2+ supplementation in protecting against neurotoxins. Whereas, TRPM7 overexpression not only maintained Mg2+ homeostasis but also inhibited caspase 3 activity that induced cell survival. Overall, these results suggest a significant role of TRPM7 channels in Mg2+ homeostasis and the survival of neurotoxin-induced loss of dopaminergic cells." @default.
• W2965176285 created "2019-08-13" @default.
• W2965176285 creator A5066748216 @default.
• W2965176285 creator A5072553269 @default.
• W2965176285 creator A5082568887 @default.
• W2965176285 date "2019-08-08" @default.
• W2965176285 modified "2023-10-12" @default.
• W2965176285 title "Magnesium-Induced Cell Survival Is Dependent on TRPM7 Expression and Function" @default.
• W2965176285 cites W1559892880 @default.
• W2965176285 cites W1622395950 @default.
• W2965176285 cites W1807594235 @default.
• W2965176285 cites W1845459216 @default.
• W2965176285 cites W1916783942 @default.
• W2965176285 cites W1946523045 @default.
• W2965176285 cites W1971389338 @default.
• W2965176285 cites W1981625314 @default.
• W2965176285 cites W1985433551 @default.
• W2965176285 cites W1989851876 @default.
• W2965176285 cites W1992222070 @default.
• W2965176285 cites W2000638122 @default.
• W2965176285 cites W2003298005 @default.
• W2965176285 cites W2008710503 @default.
• W2965176285 cites W2021088564 @default.
• W2965176285 cites W2022645001 @default.
• W2965176285 cites W2044031210 @default.
• W2965176285 cites W2046372462 @default.
• W2965176285 cites W2050457702 @default.
• W2965176285 cites W2052985285 @default.
• W2965176285 cites W2055380718 @default.
• W2965176285 cites W2056567478 @default.
• W2965176285 cites W2065748878 @default.
• W2965176285 cites W2066581734 @default.
• W2965176285 cites W2067801907 @default.
• W2965176285 cites W2077131862 @default.
• W2965176285 cites W2078712719 @default.
• W2965176285 cites W2081144498 @default.
• W2965176285 cites W2098142640 @default.
• W2965176285 cites W2099976060 @default.
• W2965176285 cites W2121208192 @default.
• W2965176285 cites W2125461230 @default.
• W2965176285 cites W2129452944 @default.
• W2965176285 cites W2130356495 @default.
• W2965176285 cites W2132357771 @default.
• W2965176285 cites W2160083769 @default.
• W2965176285 cites W2166073081 @default.
• W2965176285 cites W2169622817 @default.
• W2965176285 cites W2275437330 @default.
• W2965176285 cites W2322512950 @default.
• W2965176285 cites W2341935243 @default.
• W2965176285 cites W2563900680 @default.
• W2965176285 cites W2594339539 @default.
• W2965176285 cites W2770812943 @default.
• W2965176285 cites W2778186708 @default.
• W2965176285 cites W2783882235 @default.
• W2965176285 cites W2789588146 @default.
• W2965176285 cites W2894864865 @default.
• W2965176285 cites W2900521754 @default.
• W2965176285 cites W3202195052 @default.
• W2965176285 cites W2045695914 @default.
• W2965176285 doi "https://doi.org/10.1007/s12035-019-01713-7" @default.
• W2965176285 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6968994" @default.
• W2965176285 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31392516" @default.
• W2965176285 hasPublicationYear "2019" @default.
• W2965176285 type Work @default.
• W2965176285 sameAs 2965176285 @default.
• W2965176285 citedByCount "17" @default.
• W2965176285 countsByYear W29651762852020 @default.
• W2965176285 countsByYear W29651762852021 @default.
• W2965176285 countsByYear W29651762852022 @default.
• W2965176285 countsByYear W29651762852023 @default.
• W2965176285 crossrefType "journal-article" @default.
• W2965176285 hasAuthorship W2965176285A5066748216 @default.
• W2965176285 hasAuthorship W2965176285A5072553269 @default.
• W2965176285 hasAuthorship W2965176285A5082568887 @default.
• W2965176285 hasBestOaLocation W29651762851 @default.
• W2965176285 hasConcept C134018914 @default.
• W2965176285 hasConcept C137183658 @default.
• W2965176285 hasConcept C155164980 @default.
• W2965176285 hasConcept C170493617 @default.
• W2965176285 hasConcept C185592680 @default.
• W2965176285 hasConcept C190283241 @default.
• W2965176285 hasConcept C2776773494 @default.
• W2965176285 hasConcept C2780358027 @default.
• W2965176285 hasConcept C2780938664 @default.
• W2965176285 hasConcept C31573885 @default.
• W2965176285 hasConcept C513476851 @default.
• W2965176285 hasConcept C53467394 @default.
• W2965176285 hasConcept C55493867 @default.
• W2965176285 hasConcept C63645605 @default.
• W2965176285 hasConcept C86803240 @default.
• W2965176285 hasConcept C95444343 @default.
• W2965176285 hasConceptScore W2965176285C134018914 @default.
• W2965176285 hasConceptScore W2965176285C137183658 @default.
• W2965176285 hasConceptScore W2965176285C155164980 @default.
• W2965176285 hasConceptScore W2965176285C170493617 @default.
• W2965176285 hasConceptScore W2965176285C185592680 @default.
• W2965176285 hasConceptScore W2965176285C190283241 @default.
• W2965176285 hasConceptScore W2965176285C2776773494 @default.

• next