FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965196605> ?p ?o ?g. }

• W2965196605 endingPage "2441" @default.
• W2965196605 startingPage "2430" @default.
• W2965196605 abstract "3‐Arylsydnones are reported to possess striking pharmaceutical potency. α‐Aminoketone, a biologically active structural unit, is built at the fourth (electrophilic) position of sydnone and further derivatized with secondary amine and tetrazoles. The α‐aminoketone derivatives of sydnones coupled with secondary amines 4a – n were docked on enoyl acyl carrier protein (ACP) reductase from Mycobacterium tuberculosis , which revealed that compounds 4b , 4f , and 4i showed efficient C score values with different binding modes and hydrogen bonding. Further, these compounds were screened for antimycobacterial activity; among them, compound 4f displayed sensitivity at 6.25 μg/mL compared with the standard drug (Streptomycin) against M . tuberculosis (H 37 R V strain). In addition to this, α‐aminoketone derivatives of sydnones coupled with tetrazoles 8a – h were evaluated for antifungal activity. In the antifungal activity, compound 8b has exhibited potent activity at 6.25 μg/mL against Candida albicans and compound 8g at 0.4 μg/mL against Aspergillus fumigatus . The antifungal activities are comparatively better than standard antifungal agent Fluconazole at these drug concentrations. Alongside characterization of the final compounds by Fourier transform infrared, mass, 1 H NMR, and 13 C NMR spectral analyses, compounds 8b and 8g were confirmed by X‐ray crystallographic studies." @default.
• W2965196605 created "2019-08-13" @default.
• W2965196605 creator A5015782848 @default.
• W2965196605 creator A5041681926 @default.
• W2965196605 creator A5046685948 @default.
• W2965196605 creator A5049709221 @default.
• W2965196605 creator A5062387073 @default.
• W2965196605 creator A5085949599 @default.
• W2965196605 date "2019-07-31" @default.
• W2965196605 modified "2023-09-25" @default.
• W2965196605 title "Synthesis, Docking, and Pharmacological Evaluation of Derivatives of α‐Aminoketones Appended to Sydnones as Potent Antitubercular and Antifungal Scaffolds" @default.
• W2965196605 cites W1960534549 @default.
• W2965196605 cites W1972912421 @default.
• W2965196605 cites W1976378987 @default.
• W2965196605 cites W1984075743 @default.
• W2965196605 cites W1984847007 @default.
• W2965196605 cites W1995971293 @default.
• W2965196605 cites W2009428104 @default.
• W2965196605 cites W2009565343 @default.
• W2965196605 cites W2022723048 @default.
• W2965196605 cites W2024326954 @default.
• W2965196605 cites W2048521346 @default.
• W2965196605 cites W2051530150 @default.
• W2965196605 cites W2060836091 @default.
• W2965196605 cites W2062985631 @default.
• W2965196605 cites W2066344871 @default.
• W2965196605 cites W2071315457 @default.
• W2965196605 cites W2074309405 @default.
• W2965196605 cites W2078129420 @default.
• W2965196605 cites W2080631457 @default.
• W2965196605 cites W2082205780 @default.
• W2965196605 cites W2082221400 @default.
• W2965196605 cites W2085849265 @default.
• W2965196605 cites W2117447313 @default.
• W2965196605 cites W2149271805 @default.
• W2965196605 cites W2159047372 @default.
• W2965196605 cites W2160270692 @default.
• W2965196605 cites W2324424520 @default.
• W2965196605 cites W2467704730 @default.
• W2965196605 cites W2525917411 @default.
• W2965196605 cites W2606421482 @default.
• W2965196605 cites W2775839340 @default.
• W2965196605 cites W2780782104 @default.
• W2965196605 cites W2026099663 @default.
• W2965196605 doi "https://doi.org/10.1002/jhet.3630" @default.
• W2965196605 hasPublicationYear "2019" @default.
• W2965196605 type Work @default.
• W2965196605 sameAs 2965196605 @default.
• W2965196605 citedByCount "3" @default.
• W2965196605 countsByYear W29651966052021 @default.
• W2965196605 countsByYear W29651966052023 @default.
• W2965196605 crossrefType "journal-article" @default.
• W2965196605 hasAuthorship W2965196605A5015782848 @default.
• W2965196605 hasAuthorship W2965196605A5041681926 @default.
• W2965196605 hasAuthorship W2965196605A5046685948 @default.
• W2965196605 hasAuthorship W2965196605A5049709221 @default.
• W2965196605 hasAuthorship W2965196605A5062387073 @default.
• W2965196605 hasAuthorship W2965196605A5085949599 @default.
• W2965196605 hasConcept C142724271 @default.
• W2965196605 hasConcept C159110408 @default.
• W2965196605 hasConcept C185592680 @default.
• W2965196605 hasConcept C21951064 @default.
• W2965196605 hasConcept C2777975735 @default.
• W2965196605 hasConcept C2779685592 @default.
• W2965196605 hasConcept C2779787849 @default.
• W2965196605 hasConcept C2780827033 @default.
• W2965196605 hasConcept C2780917455 @default.
• W2965196605 hasConcept C2781069245 @default.
• W2965196605 hasConcept C41685203 @default.
• W2965196605 hasConcept C71240020 @default.
• W2965196605 hasConcept C71924100 @default.
• W2965196605 hasConcept C86803240 @default.
• W2965196605 hasConcept C89423630 @default.
• W2965196605 hasConceptScore W2965196605C142724271 @default.
• W2965196605 hasConceptScore W2965196605C159110408 @default.
• W2965196605 hasConceptScore W2965196605C185592680 @default.
• W2965196605 hasConceptScore W2965196605C21951064 @default.
• W2965196605 hasConceptScore W2965196605C2777975735 @default.
• W2965196605 hasConceptScore W2965196605C2779685592 @default.
• W2965196605 hasConceptScore W2965196605C2779787849 @default.
• W2965196605 hasConceptScore W2965196605C2780827033 @default.
• W2965196605 hasConceptScore W2965196605C2780917455 @default.
• W2965196605 hasConceptScore W2965196605C2781069245 @default.
• W2965196605 hasConceptScore W2965196605C41685203 @default.
• W2965196605 hasConceptScore W2965196605C71240020 @default.
• W2965196605 hasConceptScore W2965196605C71924100 @default.
• W2965196605 hasConceptScore W2965196605C86803240 @default.
• W2965196605 hasConceptScore W2965196605C89423630 @default.
• W2965196605 hasFunder F4320320767 @default.
• W2965196605 hasIssue "9" @default.
• W2965196605 hasLocation W29651966051 @default.
• W2965196605 hasOpenAccess W2965196605 @default.
• W2965196605 hasPrimaryLocation W29651966051 @default.
• W2965196605 hasRelatedWork W2045273628 @default.
• W2965196605 hasRelatedWork W2047271963 @default.
• W2965196605 hasRelatedWork W2064905408 @default.
• W2965196605 hasRelatedWork W2075696329 @default.
• W2965196605 hasRelatedWork W2518586256 @default.

• next