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- W2965212812 abstract "Despite being linked to the fundamental processes of chromosome segregation and offspring diversification, meiotic recombination rates vary within and between species. Recent years have seen progress in quantifying recombination rate evolution across multiple temporal and genomic scales. Nevertheless, the level of variation in recombination rate within wild populations-a key determinant of evolution in this trait-remains poorly documented on the genomic scale. To address this notable gap, we used immunofluorescent cytology to quantify genome-wide recombination rates in males from a wild population of the white-footed mouse, Peromyscus leucopus. For comparison, we measured recombination rates in a second population of male P. leucopus raised in the laboratory and in male deer mice from the subspecies Peromyscus maniculatus bairdii. Although we found differences between individuals in the genome-wide recombination rate, levels of variation were low-within populations, between populations, and between species. Quantification of synaptonemal complex length and crossover positions along chromosome 1 using a novel automated approach also revealed conservation in broad-scale crossover patterning, including strong crossover interference. We propose stabilizing selection targeting recombination or correlated processes as the explanation for these patterns." @default.
- W2965212812 created "2019-08-13" @default.
- W2965212812 creator A5033307803 @default.
- W2965212812 creator A5046908064 @default.
- W2965212812 creator A5066475103 @default.
- W2965212812 date "2019-07-31" @default.
- W2965212812 modified "2023-10-10" @default.
- W2965212812 title "Conservation of the genome-wide recombination rate in white-footed mice" @default.
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- W2965212812 doi "https://doi.org/10.1038/s41437-019-0252-9" @default.
- W2965212812 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6781155" @default.
- W2965212812 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31366913" @default.
- W2965212812 hasPublicationYear "2019" @default.
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