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- W2965231783 abstract "ABSTRACT Microglia are the resident myeloid cells in the central nervous system (CNS). The majority of microglial population relies on Csf1r signaling for survival and maintenance. However, a small subset of microglia in the murine brain can survive without Csf1r signaling, and reestablishes homeostasis after Csf1r signaling returns. Using single-cell RNA-seq, we characterized the heterogeneous microglial populations under Csf1r inhibition, including microglia lacking homeostatic markers and populations with elevated markers of monocytes, granulocytes and dendritic cells. Importantly, Mac2 is distinctively expressed in a subset of Csf1r-independent microglia cells, which were highly proliferative and shared striking similarities with those of microglial progenitors in yolk sac and early embryos. Lineage-tracing revealed that the Mac2+ population is of microglial origin and does not come from periphery monocytes. In non-treated mouse brains, Mac2+ microglia exhibited progenitor transcriptomic signature indistinguishable from those survived csf1r inhibition, supporting Mac2+ progenitor-like cells are present among homeostatic microglia." @default.
- W2965231783 created "2019-08-13" @default.
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- W2965231783 date "2019-08-01" @default.
- W2965231783 modified "2023-09-25" @default.
- W2965231783 title "A Mac2-positive progenitor-like microglial population survives independent of CSF1R signaling in adult mouse brain" @default.
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- W2965231783 doi "https://doi.org/10.1101/722090" @default.
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