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- W2965242241 abstract "Tumors are composed of phenotypically heterogeneous cancer cells that often resemble various differentiation states of their lineage of origin. Within this hierarchy, it is thought that an immature subpopulation of tumor-propagating cancer stem cells (CSCs) differentiates into non-tumorigenic progeny, providing a rationale for therapeutic strategies that specifically eradicate CSCs or induce their differentiation. The clinical success of these approaches depends on CSC differentiation being unidirectional rather than reversible, yet this question remains unresolved even in prototypically hierarchical malignancies, such as acute myeloid leukemia (AML). Here, we show in murine and human models of AML that, upon perturbation of endogenous expression of the lineage-determining transcription factor PU.1 or withdrawal of established differentiation therapies, some mature leukemia cells can de-differentiate and reacquire clonogenic and leukemogenic properties. Our results reveal plasticity of CSC maturation in AML, highlighting the need to therapeutically eradicate cancer cells across a range of differentiation states." @default.
- W2965242241 created "2019-08-13" @default.
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- W2965242241 date "2019-08-01" @default.
- W2965242241 modified "2023-10-18" @default.
- W2965242241 title "Interconversion between Tumorigenic and Differentiated States in Acute Myeloid Leukemia" @default.
- W2965242241 cites W1255676896 @default.
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- W2965242241 cites W1972164385 @default.
- W2965242241 cites W1977099733 @default.
- W2965242241 cites W1991415686 @default.
- W2965242241 cites W1991562400 @default.
- W2965242241 cites W1991817025 @default.
- W2965242241 cites W1996501345 @default.
- W2965242241 cites W1998728654 @default.
- W2965242241 cites W2001142914 @default.
- W2965242241 cites W2004878973 @default.
- W2965242241 cites W2005757388 @default.
- W2965242241 cites W2009886857 @default.
- W2965242241 cites W2014677321 @default.
- W2965242241 cites W2019435567 @default.
- W2965242241 cites W2021341670 @default.
- W2965242241 cites W2025000087 @default.
- W2965242241 cites W2039668015 @default.
- W2965242241 cites W2041356430 @default.
- W2965242241 cites W2047793174 @default.
- W2965242241 cites W2053937610 @default.
- W2965242241 cites W2060618743 @default.
- W2965242241 cites W2061182454 @default.
- W2965242241 cites W2070417053 @default.
- W2965242241 cites W2081098333 @default.
- W2965242241 cites W2081654176 @default.
- W2965242241 cites W2083782960 @default.
- W2965242241 cites W2088740611 @default.
- W2965242241 cites W2090982381 @default.
- W2965242241 cites W2093146349 @default.
- W2965242241 cites W2095900642 @default.
- W2965242241 cites W2100494757 @default.
- W2965242241 cites W2101091611 @default.
- W2965242241 cites W2103441770 @default.
- W2965242241 cites W2107018762 @default.
- W2965242241 cites W2108234281 @default.
- W2965242241 cites W2108362314 @default.
- W2965242241 cites W2110828128 @default.
- W2965242241 cites W2110905563 @default.
- W2965242241 cites W2111504523 @default.
- W2965242241 cites W2114843025 @default.
- W2965242241 cites W2117131162 @default.
- W2965242241 cites W2117446917 @default.
- W2965242241 cites W2117757143 @default.
- W2965242241 cites W2119310940 @default.
- W2965242241 cites W2129338773 @default.
- W2965242241 cites W2131478115 @default.
- W2965242241 cites W2135132221 @default.
- W2965242241 cites W2137526110 @default.