Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965322511> ?p ?o ?g. }
- W2965322511 abstract "Patients with acute coronary syndrome (ACS) and previous cardiovascular disease (CVD) (stroke, peripheral arterial disease [PAD] or coronary artery disease [CAD]) are at high risk of serious events and mortality. Current clinical guidelines recommend new antiplatelet drugs (NADs) for high cardiovascular risk patients with ACS; however, these drugs are underused in different scenarios.This study included 1717 ACS patients from 3 tertiary hospitals. Of them, 641 (37.33%) suffered from previous CVD: 149 patients with stroke, 154 patients with PAD and 541 patients with CAD. Bleeding, mortality and major adverse cardiac events (MACE) at 1 year of follow-up after hospital discharge were analyzed.NADs administration during hospital stay and at discharge was less frequent in patients with previous CVDs (P<0.001, for both). Cox analysis in this cohort of patients showed that clopidogrel prescription at discharge was independently associated with MACEs (HR: 1.59 [95% CI: 1.03-2.45]; P=0.036) and with death (HR: 1.99 [95% CI: 1.00-3.98]; P=0.049) in multivariate analysis. More specifically, when ticagrelor prescription at discharge was compared with clopidogrel, a significant death reduction was found in both, the univariate and the multivariate Cox analysis (HR: 4.54 [95% CI: 2.26-9.13]; P<0.001 and HR: 2.61 [95% CI: 1.16-5.90]; P=0.021, respectively).New antiplatelet drugs, especially ticagrelor, showed lower rates of mortality in patients with CVD without differences for bleeding. Despite the recommendations of current clinical guidelines for high risk patients with ACS, the use of NADs is very low in real-life patients with previous CVD." @default.
- W2965322511 created "2019-08-13" @default.
- W2965322511 creator A5002905781 @default.
- W2965322511 creator A5008203846 @default.
- W2965322511 creator A5008598930 @default.
- W2965322511 creator A5010550577 @default.
- W2965322511 creator A5011981189 @default.
- W2965322511 creator A5028405778 @default.
- W2965322511 creator A5041420216 @default.
- W2965322511 creator A5045703717 @default.
- W2965322511 creator A5047467845 @default.
- W2965322511 creator A5049822689 @default.
- W2965322511 creator A5054435737 @default.
- W2965322511 creator A5061061743 @default.
- W2965322511 creator A5062743035 @default.
- W2965322511 creator A5078242986 @default.
- W2965322511 creator A5084629140 @default.
- W2965322511 date "2019-07-01" @default.
- W2965322511 modified "2023-10-18" @default.
- W2965322511 title "Under-prescription of novel antiplatelet drugs in patients with acute coronary syndrome and previous cardiovascular disease" @default.
- W2965322511 cites W1976114037 @default.
- W2965322511 cites W2030002316 @default.
- W2965322511 cites W2040087929 @default.
- W2965322511 cites W2041729565 @default.
- W2965322511 cites W2062574606 @default.
- W2965322511 cites W2064667702 @default.
- W2965322511 cites W2064997581 @default.
- W2965322511 cites W2065378608 @default.
- W2965322511 cites W2081606831 @default.
- W2965322511 cites W2103511697 @default.
- W2965322511 cites W2104320348 @default.
- W2965322511 cites W2105397247 @default.
- W2965322511 cites W2134900897 @default.
- W2965322511 cites W2139189482 @default.
- W2965322511 cites W2140136269 @default.
- W2965322511 cites W2140501627 @default.
- W2965322511 cites W2141358924 @default.
- W2965322511 cites W2166728273 @default.
- W2965322511 cites W2171252861 @default.
- W2965322511 cites W2324841714 @default.
- W2965322511 cites W2470008148 @default.
- W2965322511 cites W2753407454 @default.
- W2965322511 cites W2759456173 @default.
- W2965322511 cites W3183915260 @default.
- W2965322511 cites W4293372203 @default.
- W2965322511 doi "https://doi.org/10.23736/s0026-4806.19.05859-2" @default.
- W2965322511 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31081301" @default.
- W2965322511 hasPublicationYear "2019" @default.
- W2965322511 type Work @default.
- W2965322511 sameAs 2965322511 @default.
- W2965322511 citedByCount "3" @default.
- W2965322511 countsByYear W29653225112020 @default.
- W2965322511 countsByYear W29653225112021 @default.
- W2965322511 crossrefType "journal-article" @default.
- W2965322511 hasAuthorship W2965322511A5002905781 @default.
- W2965322511 hasAuthorship W2965322511A5008203846 @default.
- W2965322511 hasAuthorship W2965322511A5008598930 @default.
- W2965322511 hasAuthorship W2965322511A5010550577 @default.
- W2965322511 hasAuthorship W2965322511A5011981189 @default.
- W2965322511 hasAuthorship W2965322511A5028405778 @default.
- W2965322511 hasAuthorship W2965322511A5041420216 @default.
- W2965322511 hasAuthorship W2965322511A5045703717 @default.
- W2965322511 hasAuthorship W2965322511A5047467845 @default.
- W2965322511 hasAuthorship W2965322511A5049822689 @default.
- W2965322511 hasAuthorship W2965322511A5054435737 @default.
- W2965322511 hasAuthorship W2965322511A5061061743 @default.
- W2965322511 hasAuthorship W2965322511A5062743035 @default.
- W2965322511 hasAuthorship W2965322511A5078242986 @default.
- W2965322511 hasAuthorship W2965322511A5084629140 @default.
- W2965322511 hasConcept C126322002 @default.
- W2965322511 hasConcept C127413603 @default.
- W2965322511 hasConcept C144301174 @default.
- W2965322511 hasConcept C164705383 @default.
- W2965322511 hasConcept C2426938 @default.
- W2965322511 hasConcept C2777265216 @default.
- W2965322511 hasConcept C2777698277 @default.
- W2965322511 hasConcept C2777849778 @default.
- W2965322511 hasConcept C2778213512 @default.
- W2965322511 hasConcept C2780400711 @default.
- W2965322511 hasConcept C2780645631 @default.
- W2965322511 hasConcept C2780739214 @default.
- W2965322511 hasConcept C2780890252 @default.
- W2965322511 hasConcept C38180746 @default.
- W2965322511 hasConcept C500558357 @default.
- W2965322511 hasConcept C50382708 @default.
- W2965322511 hasConcept C71924100 @default.
- W2965322511 hasConcept C78519656 @default.
- W2965322511 hasConcept C98274493 @default.
- W2965322511 hasConceptScore W2965322511C126322002 @default.
- W2965322511 hasConceptScore W2965322511C127413603 @default.
- W2965322511 hasConceptScore W2965322511C144301174 @default.
- W2965322511 hasConceptScore W2965322511C164705383 @default.
- W2965322511 hasConceptScore W2965322511C2426938 @default.
- W2965322511 hasConceptScore W2965322511C2777265216 @default.
- W2965322511 hasConceptScore W2965322511C2777698277 @default.
- W2965322511 hasConceptScore W2965322511C2777849778 @default.
- W2965322511 hasConceptScore W2965322511C2778213512 @default.
- W2965322511 hasConceptScore W2965322511C2780400711 @default.
- W2965322511 hasConceptScore W2965322511C2780645631 @default.
- W2965322511 hasConceptScore W2965322511C2780739214 @default.