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- W2965331317 endingPage "165529" @default.
- W2965331317 startingPage "165529" @default.
- W2965331317 abstract "Guanidinoacetate Methyltransferase deficiency is an inborn error of metabolism that results in decreased creatine and increased guanidinoacetate (GAA) levels. Patients present neurological symptoms whose mechanisms are unclear. We investigated the effects of an intrastriatal administration of 10 μM of GAA (0.02 nmol/striatum) on energy metabolism, redox state, inflammation, glutamate homeostasis, and activities/immunocontents of acetylcholinesterase and Na+,K+-ATPase, as well as on memory acquisition. The neuroprotective role of creatine was also investigated. Male Wistar rats were pretreated with creatine (50 mg/kg) or saline for 7 days underwenting stereotactic surgery. Forty-eight hours after surgery, the animals (then sixty-days-old) were divided into groups: Control, GAA, GAA + Creatine, and Creatine. Experiments were performed 30 min after intrastriatal infusion. GAA decreased SDH, complexes II and IV activities, and ATP levels, but had no effect on mitochondrial mass/membrane potential. Creatine totally prevented SDH and complex II, and partially prevented COX and ATP alterations. GAA increased dichlorofluorescein levels and decreased superoxide dismutase and catalase activities. Creatine only prevented catalase and dichlorofluorescein alterations. GAA increased cytokines, nitrites levels and acetylcholinesterase activity, but not its immunocontent. Creatine prevented such effects, except nitrite levels. GAA decreased glutamate uptake, but had no effect on the immunocontent of its transporters. GAA decreased Na+,K+-ATPase activity and increased the immunocontent of its α3 subunit. The performance on the novel object recognition task was also impaired. Creatine partially prevented the changes in glutamate uptake and Na+,K+-ATPase activity, and completely prevented the memory impairment. This study helps to elucidate the protective effects of creatine against the damage caused by GAA." @default.
- W2965331317 created "2019-08-13" @default.
- W2965331317 creator A5011026162 @default.
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- W2965331317 creator A5069580110 @default.
- W2965331317 creator A5077588471 @default.
- W2965331317 creator A5088471891 @default.
- W2965331317 date "2019-11-01" @default.
- W2965331317 modified "2023-10-10" @default.
- W2965331317 title "Cross-talk between guanidinoacetate neurotoxicity, memory and possible neuroprotective role of creatine" @default.
- W2965331317 cites W1497904256 @default.
- W2965331317 cites W1518086527 @default.
- W2965331317 cites W1572433251 @default.
- W2965331317 cites W1594425991 @default.
- W2965331317 cites W1775749144 @default.
- W2965331317 cites W1794745991 @default.
- W2965331317 cites W1796740069 @default.
- W2965331317 cites W191793640 @default.
- W2965331317 cites W1953467909 @default.
- W2965331317 cites W1965392584 @default.
- W2965331317 cites W1965942744 @default.
- W2965331317 cites W1968380336 @default.
- W2965331317 cites W1971048984 @default.
- W2965331317 cites W1972693307 @default.
- W2965331317 cites W1972834562 @default.
- W2965331317 cites W1973712162 @default.
- W2965331317 cites W1974254542 @default.
- W2965331317 cites W1975066065 @default.
- W2965331317 cites W1976338471 @default.
- W2965331317 cites W1978266275 @default.
- W2965331317 cites W1987117396 @default.
- W2965331317 cites W1987171376 @default.
- W2965331317 cites W1988278904 @default.
- W2965331317 cites W1990802251 @default.
- W2965331317 cites W1995785775 @default.
- W2965331317 cites W2004576094 @default.
- W2965331317 cites W2004980098 @default.
- W2965331317 cites W2005632220 @default.
- W2965331317 cites W2007444022 @default.
- W2965331317 cites W2010307662 @default.
- W2965331317 cites W2016300251 @default.
- W2965331317 cites W2017117587 @default.
- W2965331317 cites W2017194081 @default.
- W2965331317 cites W2017692155 @default.
- W2965331317 cites W2019042812 @default.
- W2965331317 cites W2024728309 @default.
- W2965331317 cites W2026208410 @default.
- W2965331317 cites W2036838450 @default.
- W2965331317 cites W2036926931 @default.
- W2965331317 cites W2038922520 @default.
- W2965331317 cites W2040933195 @default.
- W2965331317 cites W2049848088 @default.
- W2965331317 cites W2054554813 @default.
- W2965331317 cites W2056803906 @default.
- W2965331317 cites W2059360060 @default.
- W2965331317 cites W2062493612 @default.
- W2965331317 cites W2064183980 @default.
- W2965331317 cites W2064678740 @default.
- W2965331317 cites W2064727824 @default.
- W2965331317 cites W2067955106 @default.
- W2965331317 cites W2068665975 @default.
- W2965331317 cites W2072985278 @default.
- W2965331317 cites W2073891844 @default.
- W2965331317 cites W2075501574 @default.
- W2965331317 cites W2077129553 @default.
- W2965331317 cites W2078069732 @default.
- W2965331317 cites W2078178501 @default.
- W2965331317 cites W2078767861 @default.
- W2965331317 cites W2082480208 @default.
- W2965331317 cites W2082539152 @default.
- W2965331317 cites W2087041798 @default.
- W2965331317 cites W2087800507 @default.
- W2965331317 cites W2088272283 @default.
- W2965331317 cites W2090465196 @default.
- W2965331317 cites W2090742663 @default.
- W2965331317 cites W2095048458 @default.
- W2965331317 cites W2095348472 @default.
- W2965331317 cites W2099101508 @default.
- W2965331317 cites W2102846480 @default.
- W2965331317 cites W2111033676 @default.
- W2965331317 cites W2113788141 @default.
- W2965331317 cites W2121212243 @default.
- W2965331317 cites W2122386753 @default.
- W2965331317 cites W2126817185 @default.
- W2965331317 cites W2127907237 @default.
- W2965331317 cites W2130167079 @default.
- W2965331317 cites W2138733394 @default.
- W2965331317 cites W2142587255 @default.
- W2965331317 cites W2145213346 @default.
- W2965331317 cites W2155202745 @default.
- W2965331317 cites W2166171037 @default.
- W2965331317 cites W2170972174 @default.
- W2965331317 cites W2203189616 @default.
- W2965331317 cites W2212369426 @default.
- W2965331317 cites W2231020473 @default.