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• W2965356860 abstract "Abstract Axon regeneration following neuronal injury is an important repair mechanism that is not well understood at present. In Caenorhabditis elegans, axon regeneration is regulated by DDR-2, a receptor tyrosine kinase (RTK) that contains a discoidin domain and modulates the Met-like SVH-2 RTK–JNK MAP kinase signaling pathway. Here, we describe the svh-10/sqv-3 and svh-11 genes, which encode components of a conserved glycosylation pathway, and show that they modulate axon regeneration in C. elegans. Overexpression of svh-2, but not of ddr-2, can suppress the axon regeneration defect observed in svh-11 mutants, suggesting that SVH-11 functions between DDR-2 and SVH-2 in this glycosylation pathway. Furthermore, we found that DDR-2 is N-glycosylated at the Asn-141 residue located in its discoidin domain, and mutation of this residue caused an axon regeneration defect. These findings indicate that N-linked glycosylation plays an important role in axon regeneration in C. elegans." @default.
• W2965356860 created "2019-08-13" @default.
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• W2965356860 date "2019-10-01" @default.
• W2965356860 modified "2023-09-26" @default.
• W2965356860 title "<i>N</i>-Glycosylation of the Discoidin Domain Receptor Is Required for Axon Regeneration in <i>Caenorhabditis elegans</i>" @default.
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• W2965356860 doi "https://doi.org/10.1534/genetics.119.302492" @default.
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