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- W2965371305 abstract "Nuclear actin is exported from the nucleus via the Exportin-6 (XPO6)/RAN GTPase complex. We recently identified that RASSF1A and the hippo pathway kinase Mammalian STE20-like protein kinase 2 (MST2) play a pivotal role in nucleocytoplasmic shuttling of actin by regulating the association of XPO6 with RAN GTPase. Importantly, loss of Ras association domain family 1A (RASSF1A) and hippo signaling in cancer cells highlights a key mechanism by which nuclear actin promotes tumorigenesis." @default.
- W2965371305 created "2019-08-13" @default.
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- W2965371305 date "2019-07-29" @default.
- W2965371305 modified "2023-09-27" @default.
- W2965371305 title "When Hippo meets actin in the nucleus" @default.
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- W2965371305 doi "https://doi.org/10.1080/23723556.2019.1638728" @default.
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