Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965377811> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2965377811 endingPage "1686" @default.
- W2965377811 startingPage "1679" @default.
- W2965377811 abstract "Abstract It is known that copper (Cu) is highly accumulated in several organs in the perinatal period, suggesting changes in Cu metabolism with development, although the precise mechanisms are still unclear. To elucidate the mechanisms underlying Cu accumulation in the organs of neonatal rats, we performed speciation analysis using high-performance liquid chromatography hyphenated to inductively coupled plasma mass spectrometry. In the neonatal rat liver immediately after birth, the Cu concentration was elevated 10-fold compared to that in the juvenile rat liver. Most of the accumulated Cu was bound to metallothionein, although Cu in Cu, zinc-superoxide dismutase (SOD) was reduced. Contrary to the hepatic Cu accumulation, the serum Cu concentrations in the neonatal rats were low due to the decreased amount of Cu bound to ceruloplasmin. The mRNA expression of antioxidant protein 1 (Atox1), a Cu chaperone that transports Cu to Atp7b, remained low up to two weeks after birth. These results suggest that Cu accumulation in the neonatal rat liver is caused by the low expression of Atox1, and the accumulation is useful to distribute Cu to Cu-containing anti-oxidative enzymes (e.g., SOD and Atox1) after respiration starts." @default.
- W2965377811 created "2019-08-13" @default.
- W2965377811 creator A5057873917 @default.
- W2965377811 creator A5063250623 @default.
- W2965377811 date "2019-07-31" @default.
- W2965377811 modified "2023-10-18" @default.
- W2965377811 title "Evaluation of copper metabolism in neonatal rats by speciation analysis using liquid chromatography hyphenated to ICP mass spectrometry" @default.
- W2965377811 cites W1497069076 @default.
- W2965377811 cites W1734082729 @default.
- W2965377811 cites W1965480412 @default.
- W2965377811 cites W1971326367 @default.
- W2965377811 cites W1984227545 @default.
- W2965377811 cites W1985329347 @default.
- W2965377811 cites W19893031 @default.
- W2965377811 cites W1991173530 @default.
- W2965377811 cites W2007632640 @default.
- W2965377811 cites W2010278320 @default.
- W2965377811 cites W2010934220 @default.
- W2965377811 cites W2018411571 @default.
- W2965377811 cites W2025911925 @default.
- W2965377811 cites W2029187638 @default.
- W2965377811 cites W2032013602 @default.
- W2965377811 cites W2058861773 @default.
- W2965377811 cites W2064702079 @default.
- W2965377811 cites W2074488003 @default.
- W2965377811 cites W2089275054 @default.
- W2965377811 cites W2103378158 @default.
- W2965377811 cites W2126727119 @default.
- W2965377811 cites W2140425355 @default.
- W2965377811 cites W2162073421 @default.
- W2965377811 cites W2414303400 @default.
- W2965377811 cites W2489699581 @default.
- W2965377811 cites W2557967927 @default.
- W2965377811 cites W4229820552 @default.
- W2965377811 cites W2028155440 @default.
- W2965377811 doi "https://doi.org/10.1039/c9mt00158a" @default.
- W2965377811 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31417989" @default.
- W2965377811 hasPublicationYear "2019" @default.
- W2965377811 type Work @default.
- W2965377811 sameAs 2965377811 @default.
- W2965377811 citedByCount "10" @default.
- W2965377811 countsByYear W29653778112020 @default.
- W2965377811 countsByYear W29653778112021 @default.
- W2965377811 countsByYear W29653778112022 @default.
- W2965377811 countsByYear W29653778112023 @default.
- W2965377811 crossrefType "journal-article" @default.
- W2965377811 hasAuthorship W2965377811A5057873917 @default.
- W2965377811 hasAuthorship W2965377811A5063250623 @default.
- W2965377811 hasConcept C162356407 @default.
- W2965377811 hasConcept C165697059 @default.
- W2965377811 hasConcept C178790620 @default.
- W2965377811 hasConcept C181199279 @default.
- W2965377811 hasConcept C185592680 @default.
- W2965377811 hasConcept C20719415 @default.
- W2965377811 hasConcept C2775838275 @default.
- W2965377811 hasConcept C2778248901 @default.
- W2965377811 hasConcept C28452662 @default.
- W2965377811 hasConcept C43617362 @default.
- W2965377811 hasConcept C535196362 @default.
- W2965377811 hasConcept C544778455 @default.
- W2965377811 hasConcept C55493867 @default.
- W2965377811 hasConcept C62231903 @default.
- W2965377811 hasConceptScore W2965377811C162356407 @default.
- W2965377811 hasConceptScore W2965377811C165697059 @default.
- W2965377811 hasConceptScore W2965377811C178790620 @default.
- W2965377811 hasConceptScore W2965377811C181199279 @default.
- W2965377811 hasConceptScore W2965377811C185592680 @default.
- W2965377811 hasConceptScore W2965377811C20719415 @default.
- W2965377811 hasConceptScore W2965377811C2775838275 @default.
- W2965377811 hasConceptScore W2965377811C2778248901 @default.
- W2965377811 hasConceptScore W2965377811C28452662 @default.
- W2965377811 hasConceptScore W2965377811C43617362 @default.
- W2965377811 hasConceptScore W2965377811C535196362 @default.
- W2965377811 hasConceptScore W2965377811C544778455 @default.
- W2965377811 hasConceptScore W2965377811C55493867 @default.
- W2965377811 hasConceptScore W2965377811C62231903 @default.
- W2965377811 hasFunder F4320334764 @default.
- W2965377811 hasIssue "10" @default.
- W2965377811 hasLocation W29653778111 @default.
- W2965377811 hasLocation W29653778112 @default.
- W2965377811 hasOpenAccess W2965377811 @default.
- W2965377811 hasPrimaryLocation W29653778111 @default.
- W2965377811 hasRelatedWork W1901477667 @default.
- W2965377811 hasRelatedWork W1905958558 @default.
- W2965377811 hasRelatedWork W1980551119 @default.
- W2965377811 hasRelatedWork W1993141660 @default.
- W2965377811 hasRelatedWork W2185455467 @default.
- W2965377811 hasRelatedWork W2207114710 @default.
- W2965377811 hasRelatedWork W2362888485 @default.
- W2965377811 hasRelatedWork W2414372639 @default.
- W2965377811 hasRelatedWork W2465908799 @default.
- W2965377811 hasRelatedWork W4250905431 @default.
- W2965377811 hasVolume "11" @default.
- W2965377811 isParatext "false" @default.
- W2965377811 isRetracted "false" @default.
- W2965377811 magId "2965377811" @default.
- W2965377811 workType "article" @default.