FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965395280> ?p ?o ?g. }

• W2965395280 endingPage "464" @default.
• W2965395280 startingPage "457" @default.
• W2965395280 abstract "Objective: The aim of this study was to evaluate the effects of 940-nm diode laser irradiation on proinflammatory cytokine secretions [interleukin (IL)-6 and IL-8] by human gingival fibroblasts in vitro. Background: Photobiomodulation has been routinely used in many dental procedures; however, the exact biological action mechanism of photobiomodulation and its therapeutic benefits have not been established. Methods: Cells derived from systemically healthy individuals were treated with three different laser parameters—6 J for 20 sec [0.84 J/cm2 (0.04 W/cm2)], 10 J for 20 sec [1.4 J/cm2 (0.07 W/cm2)], and 14 J for 20 sec [1.97 J/cm2 (0.09 W/cm2)]—in the presence and absence of 1 μg/mL lipopolysaccharide (LPS) stimulation. Laser irradiations were carried out by a 940-nm diode laser device in continuous pain therapy mode with a deep tissue handpiece. Changes in cell viability, cytokine secretions, and mitogen-activated protein kinase pathway expressions were investigated, and results were compared with negative (medium) and positive control (1 μg/mL LPS) groups. The data obtained were statistically analyzed by the Mann–Whitney U test for pairwise comparisons among groups at the 0.05 level of significance. Results: Laser therapy with 0.84–1.4 J/cm2 amplified IL-6 and IL-8 secretions, whereas 1.97 J/cm2 suppressed IL-6 and IL-8 release in LPS-stimulated cells. Cell viability did not show a variation with photobiomodulation. Conclusions: These results demonstrate that photobiomodulation can alter IL-6 and IL-8 release, with cytokine suppression potency at a relatively high dose, as demonstrated previously. However, in contrast, we found that a low level of stimulation (6 J) in the presence of inflammation (LPS stimulation) may further enhance IL-6 and IL-8 release. We also found that p38 and ERK1/2 pathways are activated by LPS as well as by photobiomodulation." @default.
• W2965395280 created "2019-08-13" @default.
• W2965395280 creator A5036053255 @default.
• W2965395280 creator A5048580605 @default.
• W2965395280 creator A5091235850 @default.
• W2965395280 date "2019-08-01" @default.
• W2965395280 modified "2023-10-18" @default.
• W2965395280 title "Effect of Photobiomodulation on Secretion of IL-6 and IL-8 by Human Gingival Fibroblasts <i>In Vitro</i>" @default.
• W2965395280 cites W1971570071 @default.
• W2965395280 cites W2003542500 @default.
• W2965395280 cites W2038358889 @default.
• W2965395280 cites W2049204919 @default.
• W2965395280 cites W2049659729 @default.
• W2965395280 cites W2062930082 @default.
• W2965395280 cites W2085902590 @default.
• W2965395280 cites W2096166085 @default.
• W2965395280 cites W2110841827 @default.
• W2965395280 cites W2111913028 @default.
• W2965395280 cites W2121361253 @default.
• W2965395280 cites W2124540381 @default.
• W2965395280 cites W2126282815 @default.
• W2965395280 cites W2128190937 @default.
• W2965395280 cites W2140830671 @default.
• W2965395280 cites W2144099695 @default.
• W2965395280 cites W2152409544 @default.
• W2965395280 cites W2160297100 @default.
• W2965395280 cites W2166645517 @default.
• W2965395280 cites W2469298799 @default.
• W2965395280 cites W2472694285 @default.
• W2965395280 cites W2518437142 @default.
• W2965395280 cites W2529724677 @default.
• W2965395280 cites W2589916357 @default.
• W2965395280 cites W2734471535 @default.
• W2965395280 cites W2767803054 @default.
• W2965395280 doi "https://doi.org/10.1089/photob.2018.4589" @default.
• W2965395280 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31390315" @default.
• W2965395280 hasPublicationYear "2019" @default.
• W2965395280 type Work @default.
• W2965395280 sameAs 2965395280 @default.
• W2965395280 citedByCount "11" @default.
• W2965395280 countsByYear W29653952802020 @default.
• W2965395280 countsByYear W29653952802021 @default.
• W2965395280 countsByYear W29653952802023 @default.
• W2965395280 crossrefType "journal-article" @default.
• W2965395280 hasAuthorship W2965395280A5036053255 @default.
• W2965395280 hasAuthorship W2965395280A5048580605 @default.
• W2965395280 hasAuthorship W2965395280A5091235850 @default.
• W2965395280 hasConcept C11988809 @default.
• W2965395280 hasConcept C120665830 @default.
• W2965395280 hasConcept C121332964 @default.
• W2965395280 hasConcept C126322002 @default.
• W2965395280 hasConcept C153911025 @default.
• W2965395280 hasConcept C164027704 @default.
• W2965395280 hasConcept C16685009 @default.
• W2965395280 hasConcept C185592680 @default.
• W2965395280 hasConcept C202751555 @default.
• W2965395280 hasConcept C203014093 @default.
• W2965395280 hasConcept C24998067 @default.
• W2965395280 hasConcept C2776914184 @default.
• W2965395280 hasConcept C2778023920 @default.
• W2965395280 hasConcept C2778690821 @default.
• W2965395280 hasConcept C2778754761 @default.
• W2965395280 hasConcept C2993195213 @default.
• W2965395280 hasConcept C49039625 @default.
• W2965395280 hasConcept C520434653 @default.
• W2965395280 hasConcept C53227056 @default.
• W2965395280 hasConcept C55493867 @default.
• W2965395280 hasConcept C68324877 @default.
• W2965395280 hasConcept C71924100 @default.
• W2965395280 hasConcept C74172505 @default.
• W2965395280 hasConcept C86803240 @default.
• W2965395280 hasConceptScore W2965395280C11988809 @default.
• W2965395280 hasConceptScore W2965395280C120665830 @default.
• W2965395280 hasConceptScore W2965395280C121332964 @default.
• W2965395280 hasConceptScore W2965395280C126322002 @default.
• W2965395280 hasConceptScore W2965395280C153911025 @default.
• W2965395280 hasConceptScore W2965395280C164027704 @default.
• W2965395280 hasConceptScore W2965395280C16685009 @default.
• W2965395280 hasConceptScore W2965395280C185592680 @default.
• W2965395280 hasConceptScore W2965395280C202751555 @default.
• W2965395280 hasConceptScore W2965395280C203014093 @default.
• W2965395280 hasConceptScore W2965395280C24998067 @default.
• W2965395280 hasConceptScore W2965395280C2776914184 @default.
• W2965395280 hasConceptScore W2965395280C2778023920 @default.
• W2965395280 hasConceptScore W2965395280C2778690821 @default.
• W2965395280 hasConceptScore W2965395280C2778754761 @default.
• W2965395280 hasConceptScore W2965395280C2993195213 @default.
• W2965395280 hasConceptScore W2965395280C49039625 @default.
• W2965395280 hasConceptScore W2965395280C520434653 @default.
• W2965395280 hasConceptScore W2965395280C53227056 @default.
• W2965395280 hasConceptScore W2965395280C55493867 @default.
• W2965395280 hasConceptScore W2965395280C68324877 @default.
• W2965395280 hasConceptScore W2965395280C71924100 @default.
• W2965395280 hasConceptScore W2965395280C74172505 @default.
• W2965395280 hasConceptScore W2965395280C86803240 @default.
• W2965395280 hasIssue "8" @default.
• W2965395280 hasLocation W29653952801 @default.
• W2965395280 hasLocation W29653952802 @default.

• next