FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965400533> ?p ?o ?g. }

• W2965400533 endingPage "3928" @default.
• W2965400533 startingPage "3920" @default.
• W2965400533 abstract "In contrast to other tumor types, immunotherapy has not yet become a relevant part of the treatment landscape of unselected colorectal cancer. Beside the small subgroup of deficient mismatch repair or microsatellite instable tumors (about 5%) as a surrogate for high mutational burden and subsequently high neoantigen load and immunogenicity, inhibitors of programmed death 1 (PD-1), programmed death ligand 1 (PD-L1) and/or cytotoxic T lymphocyte-associated antigen-4 were not or only modestly effective in metastatic colorectal cancer. Thus, a variety of combination approaches with chemotherapy, targeted therapy, toll-like receptor agonists, local ablation or oncolytic viruses is currently being evaluated in different disease settings. Despite several encouraging single arm data already presented or published, available randomized data are unimpressive. Adding PD-1/PD-L1 inhibitors to fluoropyrimidines and bevacizumab maintenance showed no beneficial impact on delaying progression. In refractory disease, the combination of PD-1/PD-L1 and MEK inhibitor was not different from regorafenib, whereas a PD-1/PD-L1 and cytotoxic T lymphocyte-associated antigen-4 inhibitor combination demonstrated better overall survival compared to supportive care alone. Clinical trials in all disease settings applying different combination approaches are ongoing and may define the role of immunotherapy in colorectal cancer." @default.
• W2965400533 created "2019-08-13" @default.
• W2965400533 creator A5027677462 @default.
• W2965400533 creator A5084086757 @default.
• W2965400533 date "2019-08-07" @default.
• W2965400533 modified "2023-10-14" @default.
• W2965400533 title "Immunotherapy in colorectal cancer: Available clinical evidence, challenges and novel approaches" @default.
• W2965400533 cites W1493941926 @default.
• W2965400533 cites W1510865194 @default.
• W2965400533 cites W1575272888 @default.
• W2965400533 cites W1785873212 @default.
• W2965400533 cites W1934094702 @default.
• W2965400533 cites W1940241680 @default.
• W2965400533 cites W1984642649 @default.
• W2965400533 cites W1987516241 @default.
• W2965400533 cites W2020447109 @default.
• W2965400533 cites W2022837929 @default.
• W2965400533 cites W2076948707 @default.
• W2965400533 cites W2079018735 @default.
• W2965400533 cites W2094481139 @default.
• W2965400533 cites W2101653483 @default.
• W2965400533 cites W2124513722 @default.
• W2965400533 cites W2138651252 @default.
• W2965400533 cites W2140231263 @default.
• W2965400533 cites W2141121704 @default.
• W2965400533 cites W2177327503 @default.
• W2965400533 cites W2179115666 @default.
• W2965400533 cites W2201214180 @default.
• W2965400533 cites W2206574826 @default.
• W2965400533 cites W2289851792 @default.
• W2965400533 cites W2310046094 @default.
• W2965400533 cites W2336798453 @default.
• W2965400533 cites W2339723519 @default.
• W2965400533 cites W2397771749 @default.
• W2965400533 cites W2494461917 @default.
• W2965400533 cites W2511308239 @default.
• W2965400533 cites W2528386527 @default.
• W2965400533 cites W2559953355 @default.
• W2965400533 cites W2588209419 @default.
• W2965400533 cites W2593200928 @default.
• W2965400533 cites W2598253740 @default.
• W2965400533 cites W2600889039 @default.
• W2965400533 cites W2622499649 @default.
• W2965400533 cites W2634656227 @default.
• W2965400533 cites W2725858612 @default.
• W2965400533 cites W2737084095 @default.
• W2965400533 cites W2739132742 @default.
• W2965400533 cites W2788672255 @default.
• W2965400533 cites W2788975052 @default.
• W2965400533 cites W2789563811 @default.
• W2965400533 cites W2793972028 @default.
• W2965400533 cites W2811494160 @default.
• W2965400533 cites W2890038459 @default.
• W2965400533 cites W2890224843 @default.
• W2965400533 cites W2891267398 @default.
• W2965400533 cites W2891447967 @default.
• W2965400533 cites W2892297790 @default.
• W2965400533 cites W2898123935 @default.
• W2965400533 cites W2898246178 @default.
• W2965400533 cites W2898247809 @default.
• W2965400533 cites W2902047024 @default.
• W2965400533 cites W2904099327 @default.
• W2965400533 cites W2912145584 @default.
• W2965400533 cites W2913874229 @default.
• W2965400533 cites W4238389776 @default.
• W2965400533 doi "https://doi.org/10.3748/wjg.v25.i29.3920" @default.
• W2965400533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6689806" @default.
• W2965400533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31413527" @default.
• W2965400533 hasPublicationYear "2019" @default.
• W2965400533 type Work @default.
• W2965400533 sameAs 2965400533 @default.
• W2965400533 citedByCount "38" @default.
• W2965400533 countsByYear W29654005332019 @default.
• W2965400533 countsByYear W29654005332020 @default.
• W2965400533 countsByYear W29654005332021 @default.
• W2965400533 countsByYear W29654005332022 @default.
• W2965400533 countsByYear W29654005332023 @default.
• W2965400533 crossrefType "journal-article" @default.
• W2965400533 hasAuthorship W2965400533A5027677462 @default.
• W2965400533 hasAuthorship W2965400533A5084086757 @default.
• W2965400533 hasBestOaLocation W29654005331 @default.
• W2965400533 hasConcept C121608353 @default.
• W2965400533 hasConcept C126322002 @default.
• W2965400533 hasConcept C143998085 @default.
• W2965400533 hasConcept C203014093 @default.
• W2965400533 hasConcept C2776248978 @default.
• W2965400533 hasConcept C2776694085 @default.
• W2965400533 hasConcept C2777701055 @default.
• W2965400533 hasConcept C2777802072 @default.
• W2965400533 hasConcept C526805850 @default.
• W2965400533 hasConcept C71924100 @default.
• W2965400533 hasConcept C82210918 @default.
• W2965400533 hasConceptScore W2965400533C121608353 @default.
• W2965400533 hasConceptScore W2965400533C126322002 @default.
• W2965400533 hasConceptScore W2965400533C143998085 @default.
• W2965400533 hasConceptScore W2965400533C203014093 @default.
• W2965400533 hasConceptScore W2965400533C2776248978 @default.
• W2965400533 hasConceptScore W2965400533C2776694085 @default.

• next