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- W2965405589 abstract "Abstract Cell-free circulating DNA (cfDNA) and circulating tumor cells (CTCs) are emerging minimally invasive biomarkers, which help in early diagnosis, prognosis and therapeutic target selection. Combined use of cfDNA and CTCs provides complementary information about tumor cell heterogeneity thus helping to identify genetic mutations relevant in clinical decision making. Here we designed and implemented targeted sequencing of a customized cancer panel including 51 actionable genes across cfDNA and CTCs of 20 gynecologic cancer patients. As a result, we confirmed that common variants overlapped only 15.8% between cfDNA and CTCs. Most variants were found only in cfDNA or CTCs. The dual analysis of cfDNA and CTCs enabled additional mutations to be detected thus improving the accuracy of the tumor characteristics analyses. Moreover, we predicted the impact of these genetic variants on protein function using in silico methods. Overall, NGS analysis of combined cfDNA and CTCs data promise more effective methods than cfDNA or CTC alone in liquid biopsy and precision medicine for cancer therapy." @default.
- W2965405589 created "2019-08-13" @default.
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- W2965405589 date "2019-03-15" @default.
- W2965405589 modified "2023-09-23" @default.
- W2965405589 title "Comprehensive mutation profiling of both cfDNA and CTCs in gynecological cancer patients" @default.
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