Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965409720> ?p ?o ?g. }
- W2965409720 abstract "ABSTRACT Regulation of axon guidance and pruning of inappropriate synapses by class 3 semaphorins is key to development of neural circuits. Collapsin response mediator protein 2 (CRMP2) has been shown to regulate axon guidance by mediating Semaphorin 3A (Sema3A) signaling and its dysfunction has been linked to schizophrenia, however, nothing is known about its role in the synapse pruning. Here, using newly generated crmp2 −/− mice we demonstrate that while CRMP2 has only a moderate effect on Sema3A-dependent axon guidance in vivo , it is essential for Sema3F-dependent axon pruning and dendritic spine remodeling. We first demonstrate that CRMP2 deficiency interferes with Sema3A signaling in compartmentalized neuron cultures and leads to a mild defect in axon guidance in peripheral nerves and corpus callosum. Strikingly, we show that crmp2 −/− mice display more prominent defects in dendritic spine pruning and stereotyped axon pruning in hippocampus and visual cortex consistent with impaired Sema3F signaling and with autism spectrum disorder (ASD)-rather than schizophrenia-like phenotype. Indeed, we demonstrate that CRMP2 mediates Sema3F-induced axon retraction in primary neurons and that crmp2 −/− mice display early postnatal behavioral changes linked to ASD. In conclusion, we demonstrate that CRMP2 is an essential mediator of Sema3F-dependent synapse pruning and its dysfunction in early postnatal stages shares histological and behavioral features of ASD." @default.
- W2965409720 created "2019-08-13" @default.
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- W2965409720 date "2019-07-30" @default.
- W2965409720 modified "2023-09-26" @default.
- W2965409720 title "CRMP2 mediates Sema3F-dependent axon pruning and dendritic spine remodeling" @default.
- W2965409720 cites W1168911763 @default.
- W2965409720 cites W1521626316 @default.
- W2965409720 cites W1553066467 @default.
- W2965409720 cites W1584569428 @default.
- W2965409720 cites W1667693530 @default.
- W2965409720 cites W1801419844 @default.
- W2965409720 cites W1904307646 @default.
- W2965409720 cites W1931464619 @default.
- W2965409720 cites W1954850168 @default.
- W2965409720 cites W1964312080 @default.
- W2965409720 cites W1966827430 @default.
- W2965409720 cites W1967061503 @default.
- W2965409720 cites W1967534538 @default.
- W2965409720 cites W1974110822 @default.
- W2965409720 cites W1975269220 @default.
- W2965409720 cites W1977738380 @default.
- W2965409720 cites W1979258571 @default.
- W2965409720 cites W1979494388 @default.
- W2965409720 cites W1987868279 @default.
- W2965409720 cites W1994365250 @default.
- W2965409720 cites W2003634176 @default.
- W2965409720 cites W2005805156 @default.
- W2965409720 cites W2005871950 @default.
- W2965409720 cites W2008092479 @default.
- W2965409720 cites W2015574237 @default.
- W2965409720 cites W2018934769 @default.
- W2965409720 cites W2026917639 @default.
- W2965409720 cites W2040268226 @default.
- W2965409720 cites W2042984003 @default.
- W2965409720 cites W2045232671 @default.
- W2965409720 cites W2048133927 @default.
- W2965409720 cites W2051053924 @default.
- W2965409720 cites W2063120457 @default.
- W2965409720 cites W2067205837 @default.
- W2965409720 cites W2068224188 @default.
- W2965409720 cites W2068599628 @default.
- W2965409720 cites W2074434927 @default.
- W2965409720 cites W2074949013 @default.
- W2965409720 cites W2076387780 @default.
- W2965409720 cites W2076877247 @default.
- W2965409720 cites W2077523805 @default.
- W2965409720 cites W2078015875 @default.
- W2965409720 cites W2078771842 @default.
- W2965409720 cites W2080586470 @default.
- W2965409720 cites W2087065583 @default.
- W2965409720 cites W2092365132 @default.
- W2965409720 cites W2093786552 @default.
- W2965409720 cites W2098391962 @default.
- W2965409720 cites W2100728233 @default.
- W2965409720 cites W2108994842 @default.
- W2965409720 cites W2114139156 @default.
- W2965409720 cites W2114724410 @default.
- W2965409720 cites W2114838239 @default.
- W2965409720 cites W2117620907 @default.
- W2965409720 cites W2119582763 @default.
- W2965409720 cites W2120050676 @default.
- W2965409720 cites W2121914065 @default.
- W2965409720 cites W2134505400 @default.
- W2965409720 cites W2134973888 @default.
- W2965409720 cites W2138180801 @default.
- W2965409720 cites W2139753008 @default.
- W2965409720 cites W2145977550 @default.
- W2965409720 cites W2150380320 @default.
- W2965409720 cites W2159820732 @default.
- W2965409720 cites W2162500823 @default.
- W2965409720 cites W2164091580 @default.
- W2965409720 cites W2167279371 @default.
- W2965409720 cites W2167524710 @default.
- W2965409720 cites W2168245648 @default.
- W2965409720 cites W2171802424 @default.
- W2965409720 cites W2185510808 @default.
- W2965409720 cites W2479844986 @default.
- W2965409720 cites W2512118684 @default.
- W2965409720 cites W2536120694 @default.
- W2965409720 cites W2612058584 @default.
- W2965409720 cites W2804252878 @default.
- W2965409720 cites W2886989735 @default.