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- W2965431572 abstract "Environmental exposure is a growing public health burden associated with several negative health effects. An estimated 4.2 million deaths occur each year from ambient air pollution alone. Biomarkers that reflect specific exposures have the potential to measure the real integrated internal dose from all routes of complex environmental exposure. MicroRNAs (miRNAs), small non-coding RNAs that regulate gene expression, have been studied as biomarkers in various diseases and have also shown potential as environmental exposure biomarkers. Here, we review the available human epidemiological and experimental evidence of miRNA expression changes in response to specific environmental exposures including airborne particulate matter. In doing so, we establish that miRNA exposure biomarker development remains in its infancy and future studies will need to carefully consider biological and analytical ‘design rules’ in order to facilitate clinical translation." @default.
- W2965431572 created "2019-08-13" @default.
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- W2965431572 date "2019-08-19" @default.
- W2965431572 modified "2023-09-26" @default.
- W2965431572 title "MicroRNAs as biomarkers of harmful environmental and occupational exposures: a systematic review" @default.
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- W2965431572 doi "https://doi.org/10.1080/1354750x.2019.1652348" @default.
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