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• W2965458483 abstract "Abstract Rapid advances in ‘omics’ technologies have paved the way forward to an era where more ‘precise’ approaches – ‘precision’ nutrition – which leverage data on genetic variability alongside the traditional indices, have been put forth as the state-of-the-art solution to redress the effects of malnutrition across the life course. We purport that this inference is premature and that it is imperative to first review and critique the existing evidence from large-scale epidemiological findings. We set out to provide a critical evaluation of findings from genome-wide association studies (GWAS) in the roadmap to precision nutrition, focusing on GWAS of micronutrient disposition. We found that a large number of loci associated with biomarkers of micronutrient status have been identified. Mean estimates of heritability of micronutrient status ranged between 20 and 35 % for minerals, 56–59 % for water-soluble and 30–70 % for fat-soluble vitamins. With some exceptions, the majority of the identified genetic variants explained little of the overall variance in status for each micronutrient, ranging between 1·3 and 8 % (minerals), <0·1–12 % (water-soluble) and 1·7–2·3 % for (fat-soluble) vitamins. However, GWAS have provided some novel insight into mechanisms that underpin variability in micronutrient status. Our findings highlight obvious gaps that need to be addressed if the full scope of precision nutrition is ever to be realised, including research aimed at (i) dissecting the genetic basis of micronutrient deficiencies or ‘response’ to intake/supplementation (ii) identifying trans-ethnic and ethnic-specific effects (iii) identifying gene–nutrient interactions for the purpose of unravelling molecular ‘behaviour’ in a range of environmental contexts." @default.
• W2965458483 created "2019-08-13" @default.
• W2965458483 creator A5014370405 @default.
• W2965458483 creator A5038447689 @default.
• W2965458483 creator A5080594671 @default.
• W2965458483 date "2019-07-28" @default.
• W2965458483 modified "2023-09-25" @default.
• W2965458483 title "A critical evaluation of results from genome-wide association studies of micronutrient status and their utility in the practice of precision nutrition" @default.
• W2965458483 cites W1529077351 @default.
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• W2965458483 cites W1812270880 @default.
• W2965458483 cites W1933305258 @default.
• W2965458483 cites W1958017112 @default.
• W2965458483 cites W1971476169 @default.
• W2965458483 cites W1979307757 @default.
• W2965458483 cites W1980289829 @default.
• W2965458483 cites W1995768948 @default.
• W2965458483 cites W2012280926 @default.
• W2965458483 cites W2021723203 @default.
• W2965458483 cites W2022042057 @default.
• W2965458483 cites W2039127104 @default.
• W2965458483 cites W2044986828 @default.
• W2965458483 cites W2056180700 @default.
• W2965458483 cites W2062042376 @default.
• W2965458483 cites W2067724374 @default.
• W2965458483 cites W2074291593 @default.
• W2965458483 cites W2082932662 @default.
• W2965458483 cites W2095829498 @default.
• W2965458483 cites W2097195960 @default.
• W2965458483 cites W2102583984 @default.
• W2965458483 cites W2104115143 @default.
• W2965458483 cites W2104824557 @default.
• W2965458483 cites W2107787330 @default.
• W2965458483 cites W2113603970 @default.
• W2965458483 cites W2113642938 @default.
• W2965458483 cites W2113653941 @default.
• W2965458483 cites W2114340853 @default.
• W2965458483 cites W2115615699 @default.
• W2965458483 cites W2117438942 @default.
• W2965458483 cites W2118748411 @default.
• W2965458483 cites W2125836400 @default.
• W2965458483 cites W2126779745 @default.
• W2965458483 cites W2127184121 @default.
• W2965458483 cites W2129939721 @default.
• W2965458483 cites W2131205634 @default.
• W2965458483 cites W2132777764 @default.
• W2965458483 cites W2133610875 @default.
• W2965458483 cites W2133852929 @default.
• W2965458483 cites W2135963308 @default.
• W2965458483 cites W2136967659 @default.
• W2965458483 cites W2138455853 @default.
• W2965458483 cites W2139462796 @default.
• W2965458483 cites W2146399013 @default.
• W2965458483 cites W2146688715 @default.
• W2965458483 cites W2148749248 @default.
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• W2965458483 cites W2156732616 @default.
• W2965458483 cites W2160669776 @default.
• W2965458483 cites W2160710777 @default.
• W2965458483 cites W2161822077 @default.
• W2965458483 cites W2170739303 @default.
• W2965458483 cites W2173241089 @default.
• W2965458483 cites W2175465469 @default.
• W2965458483 cites W2186650314 @default.
• W2965458483 cites W2211242807 @default.
• W2965458483 cites W2226817873 @default.
• W2965458483 cites W2238160795 @default.
• W2965458483 cites W2316186137 @default.
• W2965458483 cites W2327288202 @default.
• W2965458483 cites W2342837550 @default.
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• W2965458483 doi "https://doi.org/10.1017/s0007114519001119" @default.
• W2965458483 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31362796" @default.
• W2965458483 hasPublicationYear "2019" @default.
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