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- W2965462998 startingPage "729" @default.
- W2965462998 abstract "Peste des Petits Ruminant (PPR) is an important transboundary, OIE-listed contagious viral disease of primarily sheep and goats caused by the PPR virus (PPRV), which belongs to the genus Morbillivirus of the family Paramyxoviridae. The mortality rate is 90–100%, and the morbidity rate may reach up to 100%. PPR is considered economically important as it decreases the production and productivity of livestock. In many endemic poor countries, it has remained an obstacle to the development of sustainable agriculture. Hence, proper control measures have become a necessity to prevent its rapid spread across the world. For this, detailed information on the pathogenesis of the virus and the virus host interaction through cellular receptors needs to be understood clearly. Presently, two cellular receptors; signaling lymphocyte activation molecule (SLAM) and Nectin-4 are known for PPRV. However, extensive information on virus interactions with these receptors and their impact on host immune response is still required. Hence, a thorough understanding of PPRV receptors and the mechanism involved in the induction of immunosuppression is crucial for controlling PPR. In this review, we discuss PPRV cellular receptors, viral host interaction with cellular receptors, and immunosuppression induced by the virus with reference to other Morbilliviruses." @default.
- W2965462998 created "2019-08-13" @default.
- W2965462998 creator A5006427930 @default.
- W2965462998 creator A5007628397 @default.
- W2965462998 creator A5009880741 @default.
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- W2965462998 creator A5030493071 @default.
- W2965462998 creator A5035608960 @default.
- W2965462998 creator A5083927405 @default.
- W2965462998 date "2019-08-08" @default.
- W2965462998 modified "2023-10-03" @default.
- W2965462998 title "Host Cellular Receptors for the Peste des Petits Ruminant Virus" @default.
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