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• W2965543092 abstract "Surgical manipulations of adipose tissue by removal, or partial lipectomy, have demonstrated body fat compensation and recovered body weight, suggesting that the body is able to resist changes to body composition. However, the mechanisms underlying these observations are not well understood. The purpose of this scoping review is to provide an update on what is currently known about the regulation of energetics and body fat after surgical manipulations of adipose tissue in small mammals.PubMed and Scopus were searched to identify 64 eligible studies. Outcome measures included body fat, body weight, food intake, and circulating biomarkers.Surgeries performed included lipectomy (72%) or transplantation (12%) in mice (35%), rats (35%), and other small mammals. Findings suggested that lipectomy did not have consistent long-term effects on reducing body weight and fat because regain occurred within 12 to 14 weeks post surgery. Hence, biological feedback mechanisms act to resist long-term changes of body weight or fat. Furthermore, whether this weight and fat regain occurred because of passive and active regulation under the set point or settling point theories cannot fully be discerned because of limitations in study designs and data collected.The regulation of energetics and body fat are complex and dynamic processes that require further studies of the interplay of genetic, physiological, and behavioral factors." @default.
• W2965543092 created "2019-08-13" @default.
• W2965543092 creator A5005935966 @default.
• W2965543092 creator A5043048568 @default.
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• W2965543092 creator A5062622249 @default.
• W2965543092 creator A5080902194 @default.
• W2965543092 creator A5087479886 @default.
• W2965543092 date "2019-07-30" @default.
• W2965543092 modified "2023-10-12" @default.
• W2965543092 title "A Systematic Scoping Review of Surgically Manipulated Adipose Tissue and the Regulation of Energetics and Body Fat in Animals" @default.
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• W2965543092 doi "https://doi.org/10.1002/oby.22511" @default.
• W2965543092 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6707830" @default.
• W2965543092 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31361090" @default.
• W2965543092 hasPublicationYear "2019" @default.
• W2965543092 type Work @default.

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