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- W2965591502 abstract "α -Pinene, an organic terpene compound found in coniferous trees, is used as a safe food additive and is contained in many essential oils. Moreover, some studies have shown that α -pinene suppresses neuronal activity. In this study, we investigated whether inhalation of α -pinene suppresses dizocilpine (MK-801-) induced schizophrenia-like behavioural abnormalities in mice. Mice inhaled α -pinene 1 h before the first MK-801 injection. Thirty minutes after MK-801 injection, the open field, spontaneous locomotor activity, elevated plus maze, Y-maze, tail suspension, hot plate, and grip strength tests were conducted as behavioural experiments. Inhalation of α -pinene suppressed the activity of mice in the spontaneous locomotor activity test and although it did not suppress the MK-801-induced increased locomotor activity in the open field test, it remarkably decreased the time that the mice remained in the central area. Inhalation of α -pinene suppressed the MK-801-induced increased total distance travelled in the Y-maze test, whereas it did not alter the MK-801-induced reduced threshold of antinociception in the hot plate test. In the tail suspension and grip strength tests, there was no effect on mouse behaviour by administration of MK-801 and inhalation of α -pinene. These results suggest that α -pinene acts to reduce MK-801-induced behavioural abnormalities resembling those seen in neuropsychiatric disorders. Therefore, both medicinal plants and essential oils containing α -pinene may have potential for therapeutic treatment of schizophrenia." @default.
- W2965591502 created "2019-08-13" @default.
- W2965591502 creator A5009203536 @default.
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- W2965591502 date "2019-07-30" @default.
- W2965591502 modified "2023-09-26" @default.
- W2965591502 title "Attenuation Effects of Alpha-Pinene Inhalation on Mice with Dizocilpine-Induced Psychiatric-Like Behaviour" @default.
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- W2965591502 doi "https://doi.org/10.1155/2019/2745453" @default.
- W2965591502 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6699265" @default.
- W2965591502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31467573" @default.
- W2965591502 hasPublicationYear "2019" @default.