FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965607312> ?p ?o ?g. }

• W2965607312 endingPage "10976" @default.
• W2965607312 startingPage "10965" @default.
• W2965607312 abstract "Neurons change their growth dynamics and mechanical properties in response to external stimuli such as stiffness of the local microenvironment, ambient temperature, and biochemical or geometrical guidance cues. Here we use combined atomic force microscopy (AFM) and fluorescence microscopy experiments to investigate the relationship between external temperature, soma volume, and elastic modulus for cortical neurons. We measure how changes in ambient temperature affect the volume and the mechanical properties of neuronal cells at both the bulk (elastic modulus) and local (elasticity maps) levels. The experimental data demonstrate that both the volume and the elastic modulus of the neuron soma vary with changes in temperature. Our results show a decrease by a factor of 2 in the soma elastic modulus as the ambient temperature increases from room (25 °C) to physiological (37 °C) temperature, while the volume of the soma increases by a factor of 1.3 during the same temperature sweep. Using high-resolution AFM force mapping, we measure the temperature-induced variations within different regions of the elasticity maps (low and high values of elastic modulus) and correlate these variations with the dynamics of cytoskeleton components and molecular motors. We quantify the change in soma volume with temperature and propose a simple theoretical model that relates this change with variations in soma elastic modulus. These results have significant implications for understanding neuronal development and functions, as ambient temperature, cytoskeletal dynamics, and cellular volume may change with variations in physiological conditions, for example, during tissue compression and infections in vivo as well as during cell manipulation and tissue regeneration ex vivo." @default.
• W2965607312 created "2019-08-13" @default.
• W2965607312 creator A5012511525 @default.
• W2965607312 creator A5036028920 @default.
• W2965607312 creator A5043333435 @default.
• W2965607312 creator A5057871048 @default.
• W2965607312 creator A5061756371 @default.
• W2965607312 date "2019-08-05" @default.
• W2965607312 modified "2023-10-15" @default.
• W2965607312 title "Variations of Elastic Modulus and Cell Volume with Temperature for Cortical Neurons" @default.
• W2965607312 cites W1964242194 @default.
• W2965607312 cites W1969169955 @default.
• W2965607312 cites W1969912732 @default.
• W2965607312 cites W1986197523 @default.
• W2965607312 cites W1987739439 @default.
• W2965607312 cites W1992353872 @default.
• W2965607312 cites W1998134697 @default.
• W2965607312 cites W2002208582 @default.
• W2965607312 cites W2006117550 @default.
• W2965607312 cites W2006504633 @default.
• W2965607312 cites W2012100020 @default.
• W2965607312 cites W2013328926 @default.
• W2965607312 cites W2014088819 @default.
• W2965607312 cites W2020945381 @default.
• W2965607312 cites W2025339136 @default.
• W2965607312 cites W2027658823 @default.
• W2965607312 cites W2031251406 @default.
• W2965607312 cites W2031710350 @default.
• W2965607312 cites W2033712349 @default.
• W2965607312 cites W2037010885 @default.
• W2965607312 cites W2048168136 @default.
• W2965607312 cites W2050030516 @default.
• W2965607312 cites W2059597336 @default.
• W2965607312 cites W2066957126 @default.
• W2965607312 cites W2075866529 @default.
• W2965607312 cites W2079702620 @default.
• W2965607312 cites W2085266659 @default.
• W2965607312 cites W2086565662 @default.
• W2965607312 cites W2089485530 @default.
• W2965607312 cites W2093532366 @default.
• W2965607312 cites W2096222358 @default.
• W2965607312 cites W2096624536 @default.
• W2965607312 cites W2121858600 @default.
• W2965607312 cites W2121915052 @default.
• W2965607312 cites W2123404147 @default.
• W2965607312 cites W2140512789 @default.
• W2965607312 cites W2144007430 @default.
• W2965607312 cites W2169800968 @default.
• W2965607312 cites W2232371172 @default.
• W2965607312 cites W2320031737 @default.
• W2965607312 cites W2759276314 @default.
• W2965607312 cites W2913484547 @default.
• W2965607312 cites W2944129696 @default.
• W2965607312 cites W561487252 @default.
• W2965607312 doi "https://doi.org/10.1021/acs.langmuir.9b01651" @default.
• W2965607312 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7306228" @default.
• W2965607312 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31380651" @default.
• W2965607312 hasPublicationYear "2019" @default.
• W2965607312 type Work @default.
• W2965607312 sameAs 2965607312 @default.
• W2965607312 citedByCount "19" @default.
• W2965607312 countsByYear W29656073122019 @default.
• W2965607312 countsByYear W29656073122020 @default.
• W2965607312 countsByYear W29656073122021 @default.
• W2965607312 countsByYear W29656073122022 @default.
• W2965607312 countsByYear W29656073122023 @default.
• W2965607312 crossrefType "journal-article" @default.
• W2965607312 hasAuthorship W2965607312A5012511525 @default.
• W2965607312 hasAuthorship W2965607312A5036028920 @default.
• W2965607312 hasAuthorship W2965607312A5043333435 @default.
• W2965607312 hasAuthorship W2965607312A5057871048 @default.
• W2965607312 hasAuthorship W2965607312A5061756371 @default.
• W2965607312 hasBestOaLocation W29656073122 @default.
• W2965607312 hasConcept C121332964 @default.
• W2965607312 hasConcept C121854251 @default.
• W2965607312 hasConcept C12554922 @default.
• W2965607312 hasConcept C159985019 @default.
• W2965607312 hasConcept C169760540 @default.
• W2965607312 hasConcept C185592680 @default.
• W2965607312 hasConcept C192562407 @default.
• W2965607312 hasConcept C193867417 @default.
• W2965607312 hasConcept C20556612 @default.
• W2965607312 hasConcept C2779372316 @default.
• W2965607312 hasConcept C2779617337 @default.
• W2965607312 hasConcept C43486711 @default.
• W2965607312 hasConcept C86803240 @default.
• W2965607312 hasConcept C97355855 @default.
• W2965607312 hasConceptScore W2965607312C121332964 @default.
• W2965607312 hasConceptScore W2965607312C121854251 @default.
• W2965607312 hasConceptScore W2965607312C12554922 @default.
• W2965607312 hasConceptScore W2965607312C159985019 @default.
• W2965607312 hasConceptScore W2965607312C169760540 @default.
• W2965607312 hasConceptScore W2965607312C185592680 @default.
• W2965607312 hasConceptScore W2965607312C192562407 @default.
• W2965607312 hasConceptScore W2965607312C193867417 @default.
• W2965607312 hasConceptScore W2965607312C20556612 @default.
• W2965607312 hasConceptScore W2965607312C2779372316 @default.
• W2965607312 hasConceptScore W2965607312C2779617337 @default.

• next