Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965628872> ?p ?o ?g. }
- W2965628872 endingPage "1298" @default.
- W2965628872 startingPage "1288" @default.
- W2965628872 abstract "Induced pluripotent stem cell (iPSC) technology offers a practically infinite and ethically acceptable source to obtain a variety of somatic cells. Coupled with the biotechnologies of cell therapy or tissue engineering, iPSC technology will enormously contribute to human regenerative medicine. Before clinical application, such human iPSC (hiPSC)-based therapies should be assessed using large animal models that more closely match biological or biomechanical properties of human patients. Therefore, it is critical to generate large animal iPSCs, obtain their iPSC-derived somatic cells, and preclinically evaluate their therapeutic efficacy and safety in large animals. During the past decade, the establishment of iPSC lines of a series of large animal species has been documented, and the acquisition and preclinical evaluation of iPSC-derived somatic cells has also been reported. Despite this progress, significant obstacles, such as obtaining or preserving the bona fide pluripotency of large animal iPSCs, have been encountered. Simultaneously, studies of large animal iPSCs have been overlooked in comparison with those of mouse and hiPSCs, and this field deserves more attention and support due to its important preclinical relevance. Herein, this review will focus on the large animal models of pigs, dogs, horses, and sheep/goats, and summarize current progress, challenges, and potential future directions of research on large animal iPSCs." @default.
- W2965628872 created "2019-08-13" @default.
- W2965628872 creator A5023475387 @default.
- W2965628872 creator A5053999625 @default.
- W2965628872 creator A5054378091 @default.
- W2965628872 creator A5073529001 @default.
- W2965628872 date "2019-10-01" @default.
- W2965628872 modified "2023-09-23" @default.
- W2965628872 title "Large Animal Models for the Clinical Application of Human Induced Pluripotent Stem Cells" @default.
- W2965628872 cites W1480171680 @default.
- W2965628872 cites W1519238448 @default.
- W2965628872 cites W1563180177 @default.
- W2965628872 cites W1568984423 @default.
- W2965628872 cites W1714206796 @default.
- W2965628872 cites W1893890319 @default.
- W2965628872 cites W1921498105 @default.
- W2965628872 cites W1963729509 @default.
- W2965628872 cites W1966370068 @default.
- W2965628872 cites W1966401136 @default.
- W2965628872 cites W1969248959 @default.
- W2965628872 cites W1971716779 @default.
- W2965628872 cites W1978705193 @default.
- W2965628872 cites W1980197759 @default.
- W2965628872 cites W1982752306 @default.
- W2965628872 cites W198588021 @default.
- W2965628872 cites W1987469787 @default.
- W2965628872 cites W1987767450 @default.
- W2965628872 cites W1989836279 @default.
- W2965628872 cites W1999624225 @default.
- W2965628872 cites W1999706672 @default.
- W2965628872 cites W2008566712 @default.
- W2965628872 cites W2009035128 @default.
- W2965628872 cites W2011671750 @default.
- W2965628872 cites W2014931987 @default.
- W2965628872 cites W2015897616 @default.
- W2965628872 cites W2016942099 @default.
- W2965628872 cites W2017345436 @default.
- W2965628872 cites W2024278252 @default.
- W2965628872 cites W2028103767 @default.
- W2965628872 cites W2033317615 @default.
- W2965628872 cites W2034962760 @default.
- W2965628872 cites W2038402852 @default.
- W2965628872 cites W2047445181 @default.
- W2965628872 cites W2048704947 @default.
- W2965628872 cites W2052075729 @default.
- W2965628872 cites W2055312969 @default.
- W2965628872 cites W2064705407 @default.
- W2965628872 cites W2072019502 @default.
- W2965628872 cites W2072524978 @default.
- W2965628872 cites W2074854586 @default.
- W2965628872 cites W2077806591 @default.
- W2965628872 cites W2078907562 @default.
- W2965628872 cites W2086876030 @default.
- W2965628872 cites W2088128367 @default.
- W2965628872 cites W2101569447 @default.
- W2965628872 cites W2103900382 @default.
- W2965628872 cites W2104010088 @default.
- W2965628872 cites W2110281714 @default.
- W2965628872 cites W2114942701 @default.
- W2965628872 cites W2125987139 @default.
- W2965628872 cites W2126326508 @default.
- W2965628872 cites W2131751293 @default.
- W2965628872 cites W2134411214 @default.
- W2965628872 cites W2141050718 @default.
- W2965628872 cites W2141483126 @default.
- W2965628872 cites W2142046859 @default.
- W2965628872 cites W2144623814 @default.
- W2965628872 cites W2146447597 @default.
- W2965628872 cites W2147663120 @default.
- W2965628872 cites W2158174238 @default.
- W2965628872 cites W2164583939 @default.
- W2965628872 cites W2167738779 @default.
- W2965628872 cites W2178016019 @default.
- W2965628872 cites W2231065089 @default.
- W2965628872 cites W2236476788 @default.
- W2965628872 cites W2238349962 @default.
- W2965628872 cites W2329757215 @default.
- W2965628872 cites W2398649138 @default.
- W2965628872 cites W2416874226 @default.
- W2965628872 cites W2417723789 @default.
- W2965628872 cites W2420925260 @default.
- W2965628872 cites W2473770674 @default.
- W2965628872 cites W2474697311 @default.
- W2965628872 cites W2521028299 @default.
- W2965628872 cites W2526095587 @default.
- W2965628872 cites W2527977135 @default.
- W2965628872 cites W2547318251 @default.
- W2965628872 cites W2554583637 @default.
- W2965628872 cites W2565733473 @default.
- W2965628872 cites W2571178891 @default.
- W2965628872 cites W2586346375 @default.
- W2965628872 cites W2591953847 @default.
- W2965628872 cites W2592061373 @default.
- W2965628872 cites W2611287423 @default.
- W2965628872 cites W2616215756 @default.
- W2965628872 cites W2759442579 @default.
- W2965628872 cites W2766518358 @default.
- W2965628872 cites W2769514387 @default.