FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965639557> ?p ?o ?g. }

• W2965639557 endingPage "12307" @default.
• W2965639557 startingPage "12303" @default.
• W2965639557 abstract "Triplex forming oligonucleotides are used as a tool for gene regulation and in DNA nanotechnology. By incorporating artificial nucleic acids, target affinity and biological stability superior to that of natural DNA may be obtained. This work demonstrates how a chimeric clamp consisting of acyclic (L)-threoninol nucleic acid (aTNA) and DNA can bind DNA and RNA by the formation of a highly stable triplex structure. The (L)-aTNA clamp is released from the target again by the addition of a releasing strand in a strand displacement type of reaction. It is shown that the clamp efficiently inhibits Bsu and T7 RNA polymerase activity and that polymerase activity is reactivated by displacing the clamp. The clamp was successfully applied to the regulation of luciferase expression by reversible binding to the mRNA. When targeting a sequence in the double stranded plasmid, 40 % downregulation of protein expression is achieved." @default.
• W2965639557 created "2019-08-13" @default.
• W2965639557 creator A5052880255 @default.
• W2965639557 creator A5066986416 @default.
• W2965639557 creator A5069163545 @default.
• W2965639557 creator A5090021722 @default.
• W2965639557 date "2019-08-29" @default.
• W2965639557 modified "2023-09-26" @default.
• W2965639557 title "Toehold‐Mediated Strand Displacement in a Triplex Forming Nucleic Acid Clamp for Reversible Regulation of Polymerase Activity and Protein Expression" @default.
• W2965639557 cites W1617520624 @default.
• W2965639557 cites W1965309833 @default.
• W2965639557 cites W1967698411 @default.
• W2965639557 cites W1970033940 @default.
• W2965639557 cites W1989018215 @default.
• W2965639557 cites W1992609573 @default.
• W2965639557 cites W1992933063 @default.
• W2965639557 cites W1994455207 @default.
• W2965639557 cites W2000644717 @default.
• W2965639557 cites W2005615084 @default.
• W2965639557 cites W2019818589 @default.
• W2965639557 cites W2042924251 @default.
• W2965639557 cites W2044349710 @default.
• W2965639557 cites W2054971082 @default.
• W2965639557 cites W2058358001 @default.
• W2965639557 cites W2065032657 @default.
• W2965639557 cites W2066353862 @default.
• W2965639557 cites W2081446791 @default.
• W2965639557 cites W2107435981 @default.
• W2965639557 cites W2114157847 @default.
• W2965639557 cites W2130447254 @default.
• W2965639557 cites W2133798407 @default.
• W2965639557 cites W2133918133 @default.
• W2965639557 cites W2135676836 @default.
• W2965639557 cites W2148611875 @default.
• W2965639557 cites W2158390129 @default.
• W2965639557 cites W2166765502 @default.
• W2965639557 cites W2169345930 @default.
• W2965639557 cites W2313993185 @default.
• W2965639557 cites W2328321875 @default.
• W2965639557 cites W2609836588 @default.
• W2965639557 cites W2768043621 @default.
• W2965639557 cites W2775457730 @default.
• W2965639557 cites W2777390300 @default.
• W2965639557 cites W2915027573 @default.
• W2965639557 cites W4242211825 @default.
• W2965639557 cites W568197246 @default.
• W2965639557 doi "https://doi.org/10.1002/chem.201903496" @default.
• W2965639557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31373735" @default.
• W2965639557 hasPublicationYear "2019" @default.
• W2965639557 type Work @default.
• W2965639557 sameAs 2965639557 @default.
• W2965639557 citedByCount "8" @default.
• W2965639557 countsByYear W29656395572020 @default.
• W2965639557 countsByYear W29656395572021 @default.
• W2965639557 countsByYear W29656395572022 @default.
• W2965639557 countsByYear W29656395572023 @default.
• W2965639557 crossrefType "journal-article" @default.
• W2965639557 hasAuthorship W2965639557A5052880255 @default.
• W2965639557 hasAuthorship W2965639557A5066986416 @default.
• W2965639557 hasAuthorship W2965639557A5069163545 @default.
• W2965639557 hasAuthorship W2965639557A5090021722 @default.
• W2965639557 hasConcept C104317684 @default.
• W2965639557 hasConcept C12554922 @default.
• W2965639557 hasConcept C127413603 @default.
• W2965639557 hasConcept C129312508 @default.
• W2965639557 hasConcept C153911025 @default.
• W2965639557 hasConcept C156719811 @default.
• W2965639557 hasConcept C185592680 @default.
• W2965639557 hasConcept C24107716 @default.
• W2965639557 hasConcept C2756471 @default.
• W2965639557 hasConcept C2776161997 @default.
• W2965639557 hasConcept C2776441376 @default.
• W2965639557 hasConcept C2780048736 @default.
• W2965639557 hasConcept C31254050 @default.
• W2965639557 hasConcept C547475151 @default.
• W2965639557 hasConcept C552990157 @default.
• W2965639557 hasConcept C55493867 @default.
• W2965639557 hasConcept C67705224 @default.
• W2965639557 hasConcept C78519656 @default.
• W2965639557 hasConcept C82381507 @default.
• W2965639557 hasConcept C84111939 @default.
• W2965639557 hasConcept C86803240 @default.
• W2965639557 hasConcept C95444343 @default.
• W2965639557 hasConceptScore W2965639557C104317684 @default.
• W2965639557 hasConceptScore W2965639557C12554922 @default.
• W2965639557 hasConceptScore W2965639557C127413603 @default.
• W2965639557 hasConceptScore W2965639557C129312508 @default.
• W2965639557 hasConceptScore W2965639557C153911025 @default.
• W2965639557 hasConceptScore W2965639557C156719811 @default.
• W2965639557 hasConceptScore W2965639557C185592680 @default.
• W2965639557 hasConceptScore W2965639557C24107716 @default.
• W2965639557 hasConceptScore W2965639557C2756471 @default.
• W2965639557 hasConceptScore W2965639557C2776161997 @default.
• W2965639557 hasConceptScore W2965639557C2776441376 @default.
• W2965639557 hasConceptScore W2965639557C2780048736 @default.
• W2965639557 hasConceptScore W2965639557C31254050 @default.
• W2965639557 hasConceptScore W2965639557C547475151 @default.
• W2965639557 hasConceptScore W2965639557C552990157 @default.

• next