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• W2965641036 abstract "To investigate the effects of a carrier’s sex and age on the segregation patterns of the trivalent of Robertsonian translocations. This retrospective study was designed to analyze the segregation patterns of the trivalent and euploidy rates of blastocysts. Data were collected from 154 couples with Robertsonian translocation (77 with a female carrier and 77 with a male carrier). Embryos were diagnosed via array comparative genomic hybridization between January 2013 and July 2017. The segregation patterns of the trivalent of 604 blastocysts were analyzed according to the carrier’s sex and age. The proportion of alternate segregation was significantly higher (82.9% vs. 55.2%) in the male carriers than in the female carriers of Robertsonian translocation, and the proportion of adjacent segregation was significantly lower (16.8% vs. 42.6%), with no difference in 3:0 segregation. The segregation patterns were similar in same-sex carriers when analyzed according to the type of translocation. The carrier’s age had no influence on the segregation patterns of the trivalent. The proportions of the trivalent’s meiotic segregation pattern differ significantly according to the carrier’s sex in Robertsonian translocations and are independent of the carrier’s age. A significantly higher proportion of alternate segregation for normal or balanced chromosome contents was observed in the blastocysts of the male carriers than in those of the female carriers." @default.
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• W2965641036 date "2019-08-07" @default.
• W2965641036 modified "2023-10-06" @default.
• W2965641036 title "Effects of a carrier’s sex and age on the segregation patterns of the trivalent of Robertsonian translocations" @default.
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• W2965641036 doi "https://doi.org/10.1007/s10815-019-01534-6" @default.
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