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- W2965642281 endingPage "460" @default.
- W2965642281 startingPage "447" @default.
- W2965642281 abstract "The high prevalence of obesity and its associated metabolic diseases has heightened the importance of understanding control of adipose tissue development and energy metabolism. In mammals, 3 types of adipocytes with different characteristics and origins have been identified: white, brown, and beige. Beige and brown adipocytes contain numerous mitochondria and have the capability to burn energy and counteract obesity, while white adipocytes store energy and are closely associated with metabolic disorders and obesity. Thus, regulation of the development and function of different adipocytes is important for controlling energy balance and combating obesity and related metabolic disorders. Melatonin is a neurohormone, which plays multiple roles in regulating inflammation, blood pressure, insulin actions, and energy metabolism. This article summarizes and discusses the role of melatonin in white, beige, and brown adipocytes, especially in affecting adipogenesis, inducing beige formation or white adipose tissue browning, enhancing brown adipose tissue mass and activities, improving anti-inflammatory and antioxidative effects, regulating adipokine secretion, and preventing body weight gain. Based on the current findings, melatonin is a potential therapeutic agent to control energy metabolism, adipogenesis, fat deposition, adiposity, and related metabolic diseases." @default.
- W2965642281 created "2019-08-13" @default.
- W2965642281 creator A5040350552 @default.
- W2965642281 creator A5045960607 @default.
- W2965642281 creator A5047581480 @default.
- W2965642281 creator A5058508346 @default.
- W2965642281 creator A5078403280 @default.
- W2965642281 date "2020-03-01" @default.
- W2965642281 modified "2023-10-13" @default.
- W2965642281 title "Elucidating the Regulatory Role of Melatonin in Brown, White, and Beige Adipocytes" @default.
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