FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965642340> ?p ?o ?g. }

• W2965642340 endingPage "2611" @default.
• W2965642340 startingPage "2601" @default.
• W2965642340 abstract "In consideration of characteristics and functions, extra-cellular signal-regulated protein kinase 5 (ERK5) signaling pathway could be a new target for spinal cord injury (SCI) treatment. Our study aimed to evaluate the roles of ERK5 signaling pathway in secondary damage of SCI.We randomly divided 70 healthy Wistar rats into five groups: ten in the blank group, 15 in the sham surgery + BIX02188 (sham + B) group, 15 in the sham surgery + dimethyl sulfoxide (DMSO; sham + D) group, 15 in the SCI + BIX02188 (SCI + B) group, and 15 in the SCI + DMSO (SCI + D) group. BIX02188 is a specific inhibitor of the ERK5 signaling pathway. SCI was induced by the application of vascular clips (with the force of 30 g) to the dura on T10 level, while rats in the sham surgery group underwent only T9-T11 laminectomy. BIX02188 or DMSO was intra-thecally injected at 1, 6, and 12 h after surgery or SCI. Spinal cord samples were taken for testing at 24 h after surgery or SCI.Expression of phosphorylated-ERK5 (p-ERK5) significantly increased after SCI. Application of BIX02188 indeed inhibited ERK5 signaling pathway and reduced the degree of spinal cord tissue injury, neutrophil infiltration and proinflammatory cytokine expression, nuclear factor-κB (NF-κB) activation and apoptosis (measured by TdT-mediated 2'-deoxyuridine 5'-triphosphate nick-end labeling, expression of Fas-ligand, BCL2-associated X [Bax], and B-cell lymphoma-2 [Bcl-2]). Double immunofluorescence revealed activation of ERK5 in neurons and microglia after SCI.ERK5 signaling pathway was activated in spinal neurons and microglia, contributing to secondary injury of SCI. Moreover, inhibition of ERK5 signaling pathway could alleviate the degree of SCI, which might be related to its regulation of infiltration of inflammatory cells and release of inflammatory cytokines, expression of NF-κB and cell apoptosis." @default.
• W2965642340 created "2019-08-13" @default.
• W2965642340 creator A5002188808 @default.
• W2965642340 creator A5019755810 @default.
• W2965642340 creator A5023986772 @default.
• W2965642340 creator A5034353434 @default.
• W2965642340 creator A5051446483 @default.
• W2965642340 creator A5053557583 @default.
• W2965642340 date "2019-11-05" @default.
• W2965642340 modified "2023-10-17" @default.
• W2965642340 title "Roles of extra-cellular signal-regulated protein kinase 5 signaling pathway in the development of spinal cord injury" @default.
• W2965642340 cites W1527455107 @default.
• W2965642340 cites W1953053167 @default.
• W2965642340 cites W1966730374 @default.
• W2965642340 cites W1968751704 @default.
• W2965642340 cites W1969212735 @default.
• W2965642340 cites W1972511274 @default.
• W2965642340 cites W1989743363 @default.
• W2965642340 cites W1991738330 @default.
• W2965642340 cites W1996405087 @default.
• W2965642340 cites W2002455222 @default.
• W2965642340 cites W2005416260 @default.
• W2965642340 cites W2006424917 @default.
• W2965642340 cites W2013463734 @default.
• W2965642340 cites W2028549252 @default.
• W2965642340 cites W2033542384 @default.
• W2965642340 cites W2036905187 @default.
• W2965642340 cites W2045563337 @default.
• W2965642340 cites W2069260718 @default.
• W2965642340 cites W2086707191 @default.
• W2965642340 cites W2088187860 @default.
• W2965642340 cites W2091348520 @default.
• W2965642340 cites W2092772666 @default.
• W2965642340 cites W2095663005 @default.
• W2965642340 cites W2103264487 @default.
• W2965642340 cites W2109859392 @default.
• W2965642340 cites W2123885531 @default.
• W2965642340 cites W2130529018 @default.
• W2965642340 cites W2140628786 @default.
• W2965642340 cites W2142713529 @default.
• W2965642340 cites W2147532387 @default.
• W2965642340 cites W2149486327 @default.
• W2965642340 cites W2154310434 @default.
• W2965642340 cites W2163134099 @default.
• W2965642340 cites W2333551700 @default.
• W2965642340 cites W2465922875 @default.
• W2965642340 doi "https://doi.org/10.1097/cm9.0000000000000362" @default.
• W2965642340 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6846248" @default.
• W2965642340 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31373906" @default.
• W2965642340 hasPublicationYear "2019" @default.
• W2965642340 type Work @default.
• W2965642340 sameAs 2965642340 @default.
• W2965642340 citedByCount "1" @default.
• W2965642340 countsByYear W29656423402022 @default.
• W2965642340 crossrefType "journal-article" @default.
• W2965642340 hasAuthorship W2965642340A5002188808 @default.
• W2965642340 hasAuthorship W2965642340A5019755810 @default.
• W2965642340 hasAuthorship W2965642340A5023986772 @default.
• W2965642340 hasAuthorship W2965642340A5034353434 @default.
• W2965642340 hasAuthorship W2965642340A5051446483 @default.
• W2965642340 hasAuthorship W2965642340A5053557583 @default.
• W2965642340 hasBestOaLocation W29656423401 @default.
• W2965642340 hasConcept C118552586 @default.
• W2965642340 hasConcept C126322002 @default.
• W2965642340 hasConcept C134018914 @default.
• W2965642340 hasConcept C164027704 @default.
• W2965642340 hasConcept C184235292 @default.
• W2965642340 hasConcept C185592680 @default.
• W2965642340 hasConcept C190283241 @default.
• W2965642340 hasConcept C203014093 @default.
• W2965642340 hasConcept C2776914184 @default.
• W2965642340 hasConcept C2778334475 @default.
• W2965642340 hasConcept C2780091945 @default.
• W2965642340 hasConcept C2780775167 @default.
• W2965642340 hasConcept C55493867 @default.
• W2965642340 hasConcept C62478195 @default.
• W2965642340 hasConcept C71924100 @default.
• W2965642340 hasConcept C86803240 @default.
• W2965642340 hasConcept C95444343 @default.
• W2965642340 hasConceptScore W2965642340C118552586 @default.
• W2965642340 hasConceptScore W2965642340C126322002 @default.
• W2965642340 hasConceptScore W2965642340C134018914 @default.
• W2965642340 hasConceptScore W2965642340C164027704 @default.
• W2965642340 hasConceptScore W2965642340C184235292 @default.
• W2965642340 hasConceptScore W2965642340C185592680 @default.
• W2965642340 hasConceptScore W2965642340C190283241 @default.
• W2965642340 hasConceptScore W2965642340C203014093 @default.
• W2965642340 hasConceptScore W2965642340C2776914184 @default.
• W2965642340 hasConceptScore W2965642340C2778334475 @default.
• W2965642340 hasConceptScore W2965642340C2780091945 @default.
• W2965642340 hasConceptScore W2965642340C2780775167 @default.
• W2965642340 hasConceptScore W2965642340C55493867 @default.
• W2965642340 hasConceptScore W2965642340C62478195 @default.
• W2965642340 hasConceptScore W2965642340C71924100 @default.
• W2965642340 hasConceptScore W2965642340C86803240 @default.
• W2965642340 hasConceptScore W2965642340C95444343 @default.
• W2965642340 hasIssue "21" @default.
• W2965642340 hasLocation W29656423401 @default.

• next