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• W2965643896 abstract "Obesity remains a prevalent and independent risk factor for life-threatening infection following major surgery. Here, we demonstrate that when mice are fed an obesogenic Western diet (WD), they become susceptible to lethal sepsis with multiple organ damage after exposure to antibiotics and an otherwise-recoverable surgical injury. Analysis of the gut microbiota in this model demonstrates that WD alone leads to loss of Bacteroidetes , a bloom of Proteobacteria , and evidence of antibiotic resistance development even before antibiotics are administered. After antibiotics and surgery, lethal sepsis with organ damage developed in in mice fed a WD with the appearance of multidrug-resistant pathogens in the liver, spleen, and blood. The importance of these findings lies in exposing how the selective pressures of diet, antibiotic exposure, and surgical injury can converge on the microbiome, resulting in lethal sepsis and organ damage without the introduction of an exogenous pathogen." @default.
• W2965643896 created "2019-08-13" @default.
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• W2965643896 date "2019-08-27" @default.
• W2965643896 modified "2023-10-10" @default.
• W2965643896 title "Mice Fed an Obesogenic Western Diet, Administered Antibiotics, and Subjected to a Sterile Surgical Procedure Develop Lethal Septicemia with Multidrug-Resistant Pathobionts" @default.
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• W2965643896 doi "https://doi.org/10.1128/mbio.00903-19" @default.
• W2965643896 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6667615" @default.
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