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• W2965660959 endingPage "e0220552" @default.
• W2965660959 startingPage "e0220552" @default.
• W2965660959 abstract "Background Combination antiretroviral therapy (cART) is associated with marked immune reconstitution. Although a long term viral suppression is achievable, not all children however, attain complete immunological recovery due to persistent immune activation. We use CD4/CD8 ratio like a marker of immune reconstitution. Methods Perinatal HIV-infected children who underwent a first-line cART, achieved viral suppression in the first year and maintained it for more than 5 years, with no viral rebound were included. Logistic models were applied to estimate the prognostic factors, clinical characteristics at cART start, of a lower CD4/CD8 ratio at the last visit. Results 146 HIV-infected children were included: 77% Caucasian, 45% male and 28% CDC C. Median age at cART initiation was 2.3 years (IQR: 0.5–6.2). 42 (30%) children received mono-dual therapy previously to cART. Time of undetectable viral load was 9.5 years (IQR: 7.8, 12.5). 33% of the children not achieved CD4/CD8 ratio >1. Univariate analysis showed an association between CD4/CD8 <1 with lower CD4 nadir and baseline CD4; older age at diagnosis and at cART initiation; and a previous exposure to mono-dual therapy. Multivariate analysis also revealed relationship between CD4/CD8 <1 and lower CD4 nadir (OR: 1.002, CI 95% 1.000–1.004) as well as previous exposure to mono-dual therapy (OR: 0.16, CI 95% 0.003–0.720). Conclusions CD4/CD8 >1 was not achieved in 33% of the children. Lower CD4 nadir and previous exposure to suboptimal therapy, before initiating cART, are factors showing independently association with a worse immune recovery (CD4/CD8 < 1)." @default.
• W2965660959 created "2019-08-13" @default.
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• W2965660959 date "2019-08-05" @default.
• W2965660959 modified "2023-09-26" @default.
• W2965660959 title "Prognostic factors of a lower CD4/CD8 ratio in long term viral suppression HIV infected children" @default.
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• W2965660959 doi "https://doi.org/10.1371/journal.pone.0220552" @default.
• W2965660959 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6681936" @default.
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