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- W2965696875 endingPage "4175" @default.
- W2965696875 startingPage "4160" @default.
- W2965696875 abstract "Tumor immunotherapy has achieved remarkable efficacy, with immune‐checkpoint inhibitors as especially promising candidates for cancer therapy. However, some issues caused by immunotherapy have raised attention, such as limited efficacy for some patients, narrow antineoplastic spectrum, and adverse reactions, suggesting that using regulators of tumor immune response may prove to be more complicated than anticipated. Current evidence indicates that different factors collectively constituting the unique tumor microenvironment promote immune tolerance, and these include the expression of co‐inhibitory molecules, the secretion of lactate, and competition for nutrients between tumor cells and immune cells. Furthermore, cancer‐associated fibroblasts, the main cellular components of solid tumors, promote immunosuppression through inhibition of T cell function and extracellular matrix remodeling. Here, we summarize the research advances in tumor immunotherapy and the latest insights into the influence of microenvironment on tumor immunotherapy." @default.
- W2965696875 created "2019-08-13" @default.
- W2965696875 creator A5014639534 @default.
- W2965696875 creator A5026815549 @default.
- W2965696875 creator A5034934652 @default.
- W2965696875 creator A5067935687 @default.
- W2965696875 creator A5081871783 @default.
- W2965696875 date "2019-08-22" @default.
- W2965696875 modified "2023-10-16" @default.
- W2965696875 title "The influence of microenvironment on tumor immunotherapy" @default.
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