FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965717703> ?p ?o ?g. }

• W2965717703 abstract "Alzheimer’s disease is a progressive neurodegenerative disease most often associated with memory deficits and cognitive decline, although less common clinical presentations are increasingly recognized. The cardinal pathological features of the disease have been known for more than one hundred years, and today the presence of these amyloid plaques and neurofibrillary tangles are still required for a pathological diagnosis. Alzheimer’s disease is the most common cause of dementia globally. There remain no effective treatment options for the great majority of patients, and the primary causes of the disease are unknown except in a small number of familial cases driven by genetic mutations. Confounding efforts to develop effective diagnostic tools and disease-modifying therapies is the realization that Alzheimer’s disease is a mixed proteinopathy (amyloid and tau) frequently associated with other age-related processes such as cerebrovascular disease and Lewy body disease. Defining the relationships between and interdependence of various co-pathologies remains an active area of investigation. This review outlines etiologically-linked pathologic features of Alzheimer’s disease, as well as those that are inevitable findings of uncertain significance, such as granulovacuolar degeneration and Hirano bodies. Other disease processes that are frequent, but not inevitable, are also discussed, including pathologic processes that can clinically mimic Alzheimer’s disease. These include cerebrovascular disease, Lewy body disease, TDP-43 proteinopathies and argyrophilic grain disease. The purpose of this review is to provide an overview of Alzheimer’s disease pathology, its defining pathologic substrates and the related pathologies that can affect diagnosis and treatment." @default.
• W2965717703 created "2019-08-13" @default.
• W2965717703 creator A5009533777 @default.
• W2965717703 creator A5025029869 @default.
• W2965717703 date "2019-08-02" @default.
• W2965717703 modified "2023-10-10" @default.
• W2965717703 title "The neuropathological diagnosis of Alzheimer’s disease" @default.
• W2965717703 cites W1239531603 @default.
• W2965717703 cites W1511517753 @default.
• W2965717703 cites W1521936611 @default.
• W2965717703 cites W1556490889 @default.
• W2965717703 cites W1587740805 @default.
• W2965717703 cites W1646060748 @default.
• W2965717703 cites W189551846 @default.
• W2965717703 cites W1921675910 @default.
• W2965717703 cites W1963568158 @default.
• W2965717703 cites W1964041350 @default.
• W2965717703 cites W1964927978 @default.
• W2965717703 cites W1965229261 @default.
• W2965717703 cites W1967823816 @default.
• W2965717703 cites W1968553823 @default.
• W2965717703 cites W1968603129 @default.
• W2965717703 cites W1969414063 @default.
• W2965717703 cites W1969979382 @default.
• W2965717703 cites W1971032265 @default.
• W2965717703 cites W1973855353 @default.
• W2965717703 cites W1974187431 @default.
• W2965717703 cites W1974433379 @default.
• W2965717703 cites W1976714975 @default.
• W2965717703 cites W1983522119 @default.
• W2965717703 cites W1983670592 @default.
• W2965717703 cites W1984766678 @default.
• W2965717703 cites W1984827962 @default.
• W2965717703 cites W1986281881 @default.
• W2965717703 cites W1990107252 @default.
• W2965717703 cites W1990752558 @default.
• W2965717703 cites W1991117563 @default.
• W2965717703 cites W1996024251 @default.
• W2965717703 cites W1999794509 @default.
• W2965717703 cites W2001451770 @default.
• W2965717703 cites W2001490949 @default.
• W2965717703 cites W2001618696 @default.
• W2965717703 cites W2004347786 @default.
• W2965717703 cites W2004814139 @default.
• W2965717703 cites W2006231600 @default.
• W2965717703 cites W2006247983 @default.
• W2965717703 cites W2010925911 @default.
• W2965717703 cites W2011769584 @default.
• W2965717703 cites W2012215271 @default.
• W2965717703 cites W2018070696 @default.
• W2965717703 cites W2018908557 @default.
• W2965717703 cites W2019718390 @default.
• W2965717703 cites W2020592632 @default.
• W2965717703 cites W2021130930 @default.
• W2965717703 cites W2022999587 @default.
• W2965717703 cites W2026022027 @default.
• W2965717703 cites W2027177575 @default.
• W2965717703 cites W2031537684 @default.
• W2965717703 cites W2034893190 @default.
• W2965717703 cites W2037196565 @default.
• W2965717703 cites W2040680390 @default.
• W2965717703 cites W2040753345 @default.
• W2965717703 cites W2048391579 @default.
• W2965717703 cites W2049771698 @default.
• W2965717703 cites W2051218719 @default.
• W2965717703 cites W2052742260 @default.
• W2965717703 cites W2053116497 @default.
• W2965717703 cites W2054926725 @default.
• W2965717703 cites W2056030442 @default.
• W2965717703 cites W2056313099 @default.
• W2965717703 cites W2059568035 @default.
• W2965717703 cites W2070137740 @default.
• W2965717703 cites W2070448139 @default.
• W2965717703 cites W2073589898 @default.
• W2965717703 cites W2073893553 @default.
• W2965717703 cites W2075444764 @default.
• W2965717703 cites W2077023014 @default.
• W2965717703 cites W2081533023 @default.
• W2965717703 cites W2081881251 @default.
• W2965717703 cites W2082429191 @default.
• W2965717703 cites W2084453905 @default.
• W2965717703 cites W2084465263 @default.
• W2965717703 cites W2084957666 @default.
• W2965717703 cites W2086978209 @default.
• W2965717703 cites W2087243986 @default.
• W2965717703 cites W2092646825 @default.
• W2965717703 cites W2094512334 @default.
• W2965717703 cites W2095578806 @default.
• W2965717703 cites W2096963202 @default.
• W2965717703 cites W2101334128 @default.
• W2965717703 cites W2104703797 @default.
• W2965717703 cites W2104977898 @default.
• W2965717703 cites W2106658584 @default.
• W2965717703 cites W2107960095 @default.
• W2965717703 cites W2111046068 @default.
• W2965717703 cites W2113126253 @default.
• W2965717703 cites W2114991107 @default.
• W2965717703 cites W2115017507 @default.
• W2965717703 cites W2115672510 @default.
• W2965717703 cites W2116451919 @default.

• next