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• W2965720362 endingPage "767" @default.
• W2965720362 startingPage "754" @default.
• W2965720362 abstract "Summary S ‐Acylation is a reversible post‐translational lipid modification in which a long chain fatty acid covalently attaches to specific cysteine(s) of proteins via a thioester bond. It enhances the hydrophobicity of proteins, contributes to their membrane association and plays roles in protein trafficking, stability and signalling. A family of P rotein S ‐ A cyl T ransferases ( PAT s) is responsible for this reaction. PAT s are multi‐pass transmembrane proteins that possess a catalytic Asp−His−His−Cys cysteine‐rich domain ( DHHC ‐ CRD ). In Arabidopsis, there are currently 24 such PAT s, five having been characterized, revealing their important roles in growth, development, senescence and stress responses. Here, we report the functional characterization of another PAT , At PAT 21, demonstrating the roles it plays in Arabidopsis sexual reproduction. Loss‐of‐function mutation by T‐ DNA insertion in At PAT 21 results in the complete failure of seed production. Detailed studies revealed that the sterility of the mutant is caused by defects in both male and female sporogenesis and gametogenesis. To determine if the sterility observed in atpat21‐1 was caused by upstream defects in meiosis, we assessed meiotic progression in pollen mother cells and found massive chromosome fragmentation and the absence of synapsis in the initial stages of meiosis. Interestingly, the fragmentation phenotype was substantially reduced in atpat21‐1 spo11‐1 double mutants, indicating that At PAT 21 is required for repair, but not for the formation, of SPO 11‐induced meiotic DNA double‐stranded breaks ( DSB s) in Arabidopsis. Our data highlight the importance of protein S ‐acylation in the early meiotic stages that lead to the development of male and female sporophytic reproductive structures and associated gametophytes in Arabidopsis." @default.
• W2965720362 created "2019-08-13" @default.
• W2965720362 creator A5011361351 @default.
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• W2965720362 date "2019-09-12" @default.
• W2965720362 modified "2023-10-18" @default.
• W2965720362 title "Both male and female gametogenesis require a fully functional protein<i>S‐</i>acyl transferase 21 in<i>Arabidopsis thaliana</i>" @default.
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• W2965720362 doi "https://doi.org/10.1111/tpj.14475" @default.
• W2965720362 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31369173" @default.
• W2965720362 hasPublicationYear "2019" @default.
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