Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965724539> ?p ?o ?g. }
- W2965724539 endingPage "C812" @default.
- W2965724539 startingPage "C800" @default.
- W2965724539 abstract "Orexin is a peptide neurotransmitter released in the globus pallidus. Morphological evidence reveals that both orexin 1 receptor (OX 1 R) and orexin 2 receptor (OX 2 R) exist in the globus pallidus. Here we showed that bilateral microinjection of both orexin-A and orexin-B into the globus pallidus alleviated motor deficits in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonian mice. Further in vivo extracellular single-unit recording revealed that the basal spontaneous firing rate of the globus pallidus neurons in MPTP parkinsonian mice was slower than that of normal mice. Application of orexin-A or orexin-B significantly increased the spontaneous firing rate of pallidal neurons. The influx of Ca 2+ through the L-type Ca 2+ channel is the major mechanism involved in orexin-induced excitation in the globus pallidus. Orexin-A-induced increase in firing rate of pallidal neurons in MPTP parkinsonian mice was stronger than that of normal mice. Orexin-A exerted both electrophysiological and behavioral effects mainly via OX 1 R, and orexin-B exerted the effects via OX 2 R. Endogenous orexins modulated the excitability of globus pallidus neurons mainly through OX 1 R. The present behavioral and electrophysiological results suggest that orexins ameliorate parkinsonian motor deficits through increasing the spontaneous firing of globus pallidus neurons." @default.
- W2965724539 created "2019-08-13" @default.
- W2965724539 creator A5013003010 @default.
- W2965724539 creator A5013289078 @default.
- W2965724539 creator A5013502989 @default.
- W2965724539 creator A5018200134 @default.
- W2965724539 creator A5029747713 @default.
- W2965724539 creator A5045913362 @default.
- W2965724539 creator A5071151975 @default.
- W2965724539 creator A5072310857 @default.
- W2965724539 creator A5073914080 @default.
- W2965724539 date "2019-10-01" @default.
- W2965724539 modified "2023-10-16" @default.
- W2965724539 title "Orexins alleviate motor deficits via increasing firing activity of pallidal neurons in a mouse model of Parkinson’s disease" @default.
- W2965724539 cites W1196411315 @default.
- W2965724539 cites W1627229807 @default.
- W2965724539 cites W1768450208 @default.
- W2965724539 cites W1832682301 @default.
- W2965724539 cites W188167722 @default.
- W2965724539 cites W1959892192 @default.
- W2965724539 cites W1966280554 @default.
- W2965724539 cites W1979616288 @default.
- W2965724539 cites W1982535961 @default.
- W2965724539 cites W1983445020 @default.
- W2965724539 cites W1987971960 @default.
- W2965724539 cites W1989051865 @default.
- W2965724539 cites W1995252784 @default.
- W2965724539 cites W1995429312 @default.
- W2965724539 cites W2003418022 @default.
- W2965724539 cites W2008898266 @default.
- W2965724539 cites W2013655437 @default.
- W2965724539 cites W2013724137 @default.
- W2965724539 cites W2015637398 @default.
- W2965724539 cites W2017200167 @default.
- W2965724539 cites W2024400557 @default.
- W2965724539 cites W2030204595 @default.
- W2965724539 cites W2031872434 @default.
- W2965724539 cites W2039633685 @default.
- W2965724539 cites W2040412220 @default.
- W2965724539 cites W2043899667 @default.
- W2965724539 cites W2044325467 @default.
- W2965724539 cites W2057688503 @default.
- W2965724539 cites W2059713492 @default.
- W2965724539 cites W2070801122 @default.
- W2965724539 cites W2073129519 @default.
- W2965724539 cites W2082442002 @default.
- W2965724539 cites W2084675191 @default.
- W2965724539 cites W2088626634 @default.
- W2965724539 cites W2092804224 @default.
- W2965724539 cites W2093361067 @default.
- W2965724539 cites W2098228975 @default.
- W2965724539 cites W2110607635 @default.
- W2965724539 cites W2120051502 @default.
- W2965724539 cites W2123393003 @default.
- W2965724539 cites W2128464706 @default.
- W2965724539 cites W2143505927 @default.
- W2965724539 cites W2145316947 @default.
- W2965724539 cites W2150515709 @default.
- W2965724539 cites W2152211310 @default.
- W2965724539 cites W2273491821 @default.
- W2965724539 cites W2277941724 @default.
- W2965724539 cites W2396340979 @default.
- W2965724539 cites W2466987715 @default.
- W2965724539 cites W2546602712 @default.
- W2965724539 cites W2605366298 @default.
- W2965724539 cites W2735209970 @default.
- W2965724539 cites W2745963176 @default.
- W2965724539 cites W2761965092 @default.
- W2965724539 cites W2765228244 @default.
- W2965724539 cites W2766166041 @default.
- W2965724539 cites W2767214712 @default.
- W2965724539 cites W2767584572 @default.
- W2965724539 cites W2772698047 @default.
- W2965724539 cites W2776242405 @default.
- W2965724539 cites W2887657572 @default.
- W2965724539 cites W2887786549 @default.
- W2965724539 cites W2887940602 @default.
- W2965724539 cites W2898978796 @default.
- W2965724539 cites W2901255516 @default.
- W2965724539 cites W2903991041 @default.
- W2965724539 cites W4232268361 @default.
- W2965724539 cites W4251967500 @default.
- W2965724539 doi "https://doi.org/10.1152/ajpcell.00125.2019" @default.
- W2965724539 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31365289" @default.
- W2965724539 hasPublicationYear "2019" @default.
- W2965724539 type Work @default.
- W2965724539 sameAs 2965724539 @default.
- W2965724539 citedByCount "14" @default.
- W2965724539 countsByYear W29657245392020 @default.
- W2965724539 countsByYear W29657245392021 @default.
- W2965724539 countsByYear W29657245392022 @default.
- W2965724539 countsByYear W29657245392023 @default.
- W2965724539 crossrefType "journal-article" @default.
- W2965724539 hasAuthorship W2965724539A5013003010 @default.
- W2965724539 hasAuthorship W2965724539A5013289078 @default.
- W2965724539 hasAuthorship W2965724539A5013502989 @default.
- W2965724539 hasAuthorship W2965724539A5018200134 @default.
- W2965724539 hasAuthorship W2965724539A5029747713 @default.