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• W2965726091 abstract "Abstract Background: The value of decolonization as a strategy for preventing methicillin-resistant Staphylococcus aureus (MRSA) in the neonatal intensive care unit (NICU) remains to be determined. Objective: After adding decolonization to further reduce MRSA transmission in our NICU, we conducted this retrospective review to evaluate its effectiveness. Method: The review included patients who were admitted to our NICU between April 2015 and June 2018 and were eligible for decolonization including twice daily intranasal mupirocin and daily chlorhexidine gluconate bathing over 5 consecutive days. Patients were considered successfully decolonized if 3 subsequent MRSA screenings conducted at 1-week intervals were negative. The MRSA acquisition rate (AR) was calculated as hospital-acquired (HA) MRSA per 1,000 patient days (PD) and was used to measure the effectiveness of the decolonization. Results: Of the 151 MRSA patients being reviewed, 78 (51.6%) were HA-MRSA, resulting in an overall AR of 1.27 per 1,000 PD. Between April 2015 and February 2016, when only the decolonization was added, the AR was 2.38 per 1,000 PD. Between March 2016 and June 2018 after unit added a technician dedicated to the cleaning of reusable equipment, the AR decreased significantly to 0.92 per 1,000 PD ( P < .05). Of the 78 patients who were started on the decolonization, 49 (62.8%) completed the protocol, 11 (14.1%) remained colonized, and 13 (16.7%) were recolonized prior to NICU discharge. Conclusion: In a NICU with comprehensive MRSA prevention measures in place, enhancing the cleaning of reusable equipment, not decolonization, led to significant reduction of MRSA transmission." @default.
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• W2965726091 date "2019-07-31" @default.
• W2965726091 modified "2023-09-25" @default.
• W2965726091 title "Impact of decolonization on methicillin-resistant <i>Staphylococcus aureus</i> transmission and infection in a neonatal intensive care unit" @default.
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• W2965726091 doi "https://doi.org/10.1017/ice.2019.217" @default.
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