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- W2965781575 abstract "To report the clinical outcomes of adalimumab in treating refractory Behcet’s disease (BD)-related uveitis in paediatric or adolescent patients. Retrospective review of five paediatric or adolescent patients with BD-related uveitis with a minimum follow-up of 24 months. Disease quiescence was observed in 9 (90%) of 10 eyes at 12 months. The mean number of relapses per year per patient was 5 (range, 3–7) before initiation of adalimumab treatment. This was reduced to 0.2 relapse per patient per year among the five patients during the first 24 months after starting adalimumab treatment. At baseline, 5 eyes had active retinal vasculitis. Retinal vasculitis resolved in all cases (100%) after starting adalimumab. The mean time to complete resolution of inflammation was 3.4 weeks. The mean ± standard deviation logMAR best-corrected visual acuity was 0.711 ± 0.63 at baseline and improved to 0.172 ± 1.04 at 12 months (P < 0.001). None of the patients developed any adverse events associated with adalimumab treatment. Adalimumab was effective in preventing irreversible sight-threatening BD-related uveitis in paediatric or adolescent patients. Adalimumab appears to be a promising treatment option for young patients with recalcitrant BD-related uveitis and has a favourable safety profile." @default.
- W2965781575 created "2019-08-13" @default.
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- W2965781575 date "2019-07-31" @default.
- W2965781575 modified "2023-10-18" @default.
- W2965781575 title "Experience of using adalimumab in treating sight-threatening paediatric or adolescent Behcet’s disease-related uveitis" @default.
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- W2965781575 doi "https://doi.org/10.1186/s12348-019-0181-z" @default.
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