FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965789849> ?p ?o ?g. }

• W2965789849 endingPage "1816" @default.
• W2965789849 startingPage "1802" @default.
• W2965789849 abstract "Objective: n-3 polyunsaturated fatty acids, especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), have beneficial effects on atherosclerosis. Although specific salutary actions have been reported, the detailed distribution of n-3 polyunsaturated fatty acids in plaque and their relevance in disease progression are unclear. Our aim was to assess the pharmacodynamics of EPA and DHA and their metabolites in atherosclerotic plaques. Approach and Results: Apolipoprotein E-deficient (Apoe −/− ) mice were fed a Western diet supplemented with EPA (1%, w/w) or DHA (1%, w/w) for 3 weeks. Imaging mass spectrometry analyses were performed in the aortic root and arch of the Apoe −/− mice to evaluate the distribution of EPA, DHA, their metabolites and the lipids containing EPA or DHA in the plaques. Liquid chromatography-mass spectrometry and histological analysis were also performed. The intima-media thickness of atherosclerotic plaque decreased in plaques containing free EPA and EPAs attached with several lipids. EPA was distributed more densely in the thin-cap plaques than in the thick-cap plaques, while DHA was more evenly distributed. In the aortic root, the distribution of total EPA level and cholesteryl esters containing EPA followed a concentration gradient from the vascular endothelium to the media. In the aortic arch, free EPA and 12-hydroxy-EPA colocalized with M2 macrophage. Conclusions: Administered EPA tends to be incorporated from the vascular lumen side and preferentially taken into the thin-cap plaque." @default.
• W2965789849 created "2019-08-13" @default.
• W2965789849 creator A5007914982 @default.
• W2965789849 creator A5009985325 @default.
• W2965789849 creator A5011127145 @default.
• W2965789849 creator A5011491287 @default.
• W2965789849 creator A5017259913 @default.
• W2965789849 creator A5021000463 @default.
• W2965789849 creator A5022029990 @default.
• W2965789849 creator A5041325123 @default.
• W2965789849 creator A5050961061 @default.
• W2965789849 creator A5059483223 @default.
• W2965789849 creator A5062118447 @default.
• W2965789849 creator A5062771713 @default.
• W2965789849 creator A5063378634 @default.
• W2965789849 creator A5063530381 @default.
• W2965789849 creator A5068591497 @default.
• W2965789849 creator A5073134409 @default.
• W2965789849 creator A5088483233 @default.
• W2965789849 date "2019-09-01" @default.
• W2965789849 modified "2023-10-01" @default.
• W2965789849 title "Preferential Incorporation of Administered Eicosapentaenoic Acid Into Thin-Cap Atherosclerotic Plaques" @default.
• W2965789849 cites W1544184390 @default.
• W2965789849 cites W1596389679 @default.
• W2965789849 cites W1889359478 @default.
• W2965789849 cites W1971661335 @default.
• W2965789849 cites W1972483153 @default.
• W2965789849 cites W1974226247 @default.
• W2965789849 cites W1985120247 @default.
• W2965789849 cites W2019409394 @default.
• W2965789849 cites W2033610858 @default.
• W2965789849 cites W2059254076 @default.
• W2965789849 cites W2069781012 @default.
• W2965789849 cites W2071884718 @default.
• W2965789849 cites W2079501596 @default.
• W2965789849 cites W2090625804 @default.
• W2965789849 cites W2099005050 @default.
• W2965789849 cites W2110720586 @default.
• W2965789849 cites W2121322716 @default.
• W2965789849 cites W2122201881 @default.
• W2965789849 cites W2122405246 @default.
• W2965789849 cites W2132692611 @default.
• W2965789849 cites W2142347023 @default.
• W2965789849 cites W2150420078 @default.
• W2965789849 cites W2154210663 @default.
• W2965789849 cites W2155826563 @default.
• W2965789849 cites W2162465757 @default.
• W2965789849 cites W2168526937 @default.
• W2965789849 cites W2171584145 @default.
• W2965789849 cites W2236666692 @default.
• W2965789849 cites W2276012049 @default.
• W2965789849 cites W2300552860 @default.
• W2965789849 cites W2325927456 @default.
• W2965789849 cites W2336474700 @default.
• W2965789849 cites W2407464994 @default.
• W2965789849 cites W2429611686 @default.
• W2965789849 cites W2510102221 @default.
• W2965789849 cites W2523453502 @default.
• W2965789849 cites W2624982586 @default.
• W2965789849 cites W2728536122 @default.
• W2965789849 cites W2737249697 @default.
• W2965789849 cites W2764236750 @default.
• W2965789849 cites W2766451938 @default.
• W2965789849 cites W2778372284 @default.
• W2965789849 cites W2781670419 @default.
• W2965789849 cites W2781838311 @default.
• W2965789849 cites W2896260097 @default.
• W2965789849 cites W2899669642 @default.
• W2965789849 cites W2912461571 @default.
• W2965789849 cites W4256475235 @default.
• W2965789849 doi "https://doi.org/10.1161/atvbaha.119.313093" @default.
• W2965789849 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31366219" @default.
• W2965789849 hasPublicationYear "2019" @default.
• W2965789849 type Work @default.
• W2965789849 sameAs 2965789849 @default.
• W2965789849 citedByCount "31" @default.
• W2965789849 countsByYear W29657898492019 @default.
• W2965789849 countsByYear W29657898492020 @default.
• W2965789849 countsByYear W29657898492021 @default.
• W2965789849 countsByYear W29657898492022 @default.
• W2965789849 countsByYear W29657898492023 @default.
• W2965789849 crossrefType "journal-article" @default.
• W2965789849 hasAuthorship W2965789849A5007914982 @default.
• W2965789849 hasAuthorship W2965789849A5009985325 @default.
• W2965789849 hasAuthorship W2965789849A5011127145 @default.
• W2965789849 hasAuthorship W2965789849A5011491287 @default.
• W2965789849 hasAuthorship W2965789849A5017259913 @default.
• W2965789849 hasAuthorship W2965789849A5021000463 @default.
• W2965789849 hasAuthorship W2965789849A5022029990 @default.
• W2965789849 hasAuthorship W2965789849A5041325123 @default.
• W2965789849 hasAuthorship W2965789849A5050961061 @default.
• W2965789849 hasAuthorship W2965789849A5059483223 @default.
• W2965789849 hasAuthorship W2965789849A5062118447 @default.
• W2965789849 hasAuthorship W2965789849A5062771713 @default.
• W2965789849 hasAuthorship W2965789849A5063378634 @default.
• W2965789849 hasAuthorship W2965789849A5063530381 @default.
• W2965789849 hasAuthorship W2965789849A5068591497 @default.
• W2965789849 hasAuthorship W2965789849A5073134409 @default.

• next