FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965793313> ?p ?o ?g. }

• W2965793313 endingPage "13" @default.
• W2965793313 startingPage "1" @default.
• W2965793313 abstract "Abstract Excessive activation of the NLRP3 inflammasome is a key component contributing to the pathogenesis of various inflammatory diseases. However, the molecular mechanisms underlying its activation and regulation remain poorly defined. The objective of this study was to explore the possible function of the K + channel pore-forming subunit Kir6.1 in regulating NLRP3 inflammasome activation and insulin resistance. Here, we demonstrate that Kir6.1 depletion markedly activates the NLRP3 inflammasome, whereas enhanced Kir6.1 expression produces opposing effects both in mice in vivo and in primary cells in vitro. We also demonstrate that Kir6.1 controls insulin resistance by inhibiting NLRP3 inflammasome activation in mice. We further show that Kir6.1 physically associates with NLRP3 and thus inhibits the interactions between the NLRP3 inflammasome subunits. Our results reveal a previously unrecognized function of Kir6.1 as a negative regulator of the NLRP3 inflammasome and insulin resistance, which is mediated by virtue of its ability to inhibit NLRP3 inflammasome assembly. These data provide novel insights into the regulatory mechanism of NLRP3 inflammasome activation and suggest that Kir6.1 is a promising therapeutic target for inflammasome-mediated inflammatory diseases." @default.
• W2965793313 created "2019-08-13" @default.
• W2965793313 creator A5008175920 @default.
• W2965793313 creator A5013587262 @default.
• W2965793313 creator A5032240816 @default.
• W2965793313 creator A5046078938 @default.
• W2965793313 creator A5070702323 @default.
• W2965793313 creator A5088581766 @default.
• W2965793313 date "2019-08-01" @default.
• W2965793313 modified "2023-10-16" @default.
• W2965793313 title "The pore-forming subunit Kir6.1 of the K-ATP channel negatively regulates the NLRP3 inflammasome to control insulin resistance by interacting with NLRP3" @default.
• W2965793313 cites W1490154674 @default.
• W2965793313 cites W1529674879 @default.
• W2965793313 cites W1561041814 @default.
• W2965793313 cites W1577040394 @default.
• W2965793313 cites W1859128422 @default.
• W2965793313 cites W1904683780 @default.
• W2965793313 cites W1966625479 @default.
• W2965793313 cites W1972400285 @default.
• W2965793313 cites W1974210120 @default.
• W2965793313 cites W1975012711 @default.
• W2965793313 cites W1975915247 @default.
• W2965793313 cites W1983145871 @default.
• W2965793313 cites W1985538633 @default.
• W2965793313 cites W2005233485 @default.
• W2965793313 cites W2018563185 @default.
• W2965793313 cites W2018607502 @default.
• W2965793313 cites W2046421235 @default.
• W2965793313 cites W2049090812 @default.
• W2965793313 cites W2051303794 @default.
• W2965793313 cites W2051392421 @default.
• W2965793313 cites W2055313736 @default.
• W2965793313 cites W2058690999 @default.
• W2965793313 cites W2059924886 @default.
• W2965793313 cites W2061988480 @default.
• W2965793313 cites W2064456932 @default.
• W2965793313 cites W2068633454 @default.
• W2965793313 cites W2073875167 @default.
• W2965793313 cites W2079882002 @default.
• W2965793313 cites W2113511371 @default.
• W2965793313 cites W2118403357 @default.
• W2965793313 cites W2124848390 @default.
• W2965793313 cites W2134007048 @default.
• W2965793313 cites W2137573856 @default.
• W2965793313 cites W2147546596 @default.
• W2965793313 cites W2150702412 @default.
• W2965793313 cites W2155078339 @default.
• W2965793313 cites W2254807163 @default.
• W2965793313 cites W2300256671 @default.
• W2965793313 cites W2513729692 @default.
• W2965793313 cites W2522054313 @default.
• W2965793313 cites W2567439679 @default.
• W2965793313 cites W2575684964 @default.
• W2965793313 cites W2613648230 @default.
• W2965793313 cites W2724968782 @default.
• W2965793313 cites W2754415726 @default.
• W2965793313 cites W2766269101 @default.
• W2965793313 cites W2775320826 @default.
• W2965793313 doi "https://doi.org/10.1038/s12276-019-0291-6" @default.
• W2965793313 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6802643" @default.
• W2965793313 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31387986" @default.
• W2965793313 hasPublicationYear "2019" @default.
• W2965793313 type Work @default.
• W2965793313 sameAs 2965793313 @default.
• W2965793313 citedByCount "15" @default.
• W2965793313 countsByYear W29657933132020 @default.
• W2965793313 countsByYear W29657933132021 @default.
• W2965793313 countsByYear W29657933132022 @default.
• W2965793313 countsByYear W29657933132023 @default.
• W2965793313 crossrefType "journal-article" @default.
• W2965793313 hasAuthorship W2965793313A5008175920 @default.
• W2965793313 hasAuthorship W2965793313A5013587262 @default.
• W2965793313 hasAuthorship W2965793313A5032240816 @default.
• W2965793313 hasAuthorship W2965793313A5046078938 @default.
• W2965793313 hasAuthorship W2965793313A5070702323 @default.
• W2965793313 hasAuthorship W2965793313A5088581766 @default.
• W2965793313 hasBestOaLocation W29657933131 @default.
• W2965793313 hasConcept C104292427 @default.
• W2965793313 hasConcept C104317684 @default.
• W2965793313 hasConcept C134018914 @default.
• W2965793313 hasConcept C185592680 @default.
• W2965793313 hasConcept C203014093 @default.
• W2965793313 hasConcept C207001950 @default.
• W2965793313 hasConcept C2776914184 @default.
• W2965793313 hasConcept C2777209026 @default.
• W2965793313 hasConcept C2777289354 @default.
• W2965793313 hasConcept C2777391703 @default.
• W2965793313 hasConcept C2779306644 @default.
• W2965793313 hasConcept C2780942790 @default.
• W2965793313 hasConcept C54355233 @default.
• W2965793313 hasConcept C55493867 @default.
• W2965793313 hasConcept C86803240 @default.
• W2965793313 hasConcept C95444343 @default.
• W2965793313 hasConceptScore W2965793313C104292427 @default.
• W2965793313 hasConceptScore W2965793313C104317684 @default.
• W2965793313 hasConceptScore W2965793313C134018914 @default.
• W2965793313 hasConceptScore W2965793313C185592680 @default.
• W2965793313 hasConceptScore W2965793313C203014093 @default.

• next