Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965854346> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2965854346 endingPage "3128" @default.
- W2965854346 startingPage "3123" @default.
- W2965854346 abstract "Hemoglobin-vesicles (HbVs) are artificial oxygen carriers encapsulating purified and concentrated hemoglobin solution in phospholipid vesicles (liposomes) and their safety and efficacy as a transfusion alternative have been evaluated. Because of the absence of enzymatic methemoglobin reduction system in HbV, the level of ferric methemoglobin (metHb) increases gradually after intravenous administration. Our previous studies clarified that the glycolytic electron energies, charged as NAD(P)H in red blood cells (RBC), are donated to reduce metHb compartmentalized in HbV via a water-soluble electron mediator such as methylene blue [MB; 3,7-bis(dimethylamino)phenothiazinium chloride], which freely shuttle across both RBC biomembrane and HbV lipid membrane. Herein, we tried to test repeated injections of MB after the massive HbV administration (28 mL/kg) to hemorrhagic shocked Wistar rats (n = 3). MB was injected (3.1 mg/kg) at 7, 24 and 48 h after HbV administration. Every MB injection showed rapid reduction of metHb and gradual reversal increase. As a result, the functional life span of HbV was significantly extended over 60 h. It is expected that further optimization of injection scheduling will decrease the total amount of MB and prolong the functional life span of HbV." @default.
- W2965854346 created "2019-08-13" @default.
- W2965854346 creator A5005406845 @default.
- W2965854346 creator A5078805860 @default.
- W2965854346 date "2019-07-27" @default.
- W2965854346 modified "2023-09-27" @default.
- W2965854346 title "Prolonged functional life span of artificial red cells in blood circulation by repeated methylene blue injections" @default.
- W2965854346 cites W1584899782 @default.
- W2965854346 cites W1975718693 @default.
- W2965854346 cites W1976735641 @default.
- W2965854346 cites W1987236950 @default.
- W2965854346 cites W1997526188 @default.
- W2965854346 cites W2004828123 @default.
- W2965854346 cites W2011840140 @default.
- W2965854346 cites W2031187358 @default.
- W2965854346 cites W2046936082 @default.
- W2965854346 cites W2047445353 @default.
- W2965854346 cites W2051874457 @default.
- W2965854346 cites W2056557320 @default.
- W2965854346 cites W2064208105 @default.
- W2965854346 cites W2079693863 @default.
- W2965854346 cites W2089027671 @default.
- W2965854346 cites W2099747563 @default.
- W2965854346 cites W2131856131 @default.
- W2965854346 cites W2147085576 @default.
- W2965854346 cites W2154043385 @default.
- W2965854346 cites W2324528156 @default.
- W2965854346 cites W2596986385 @default.
- W2965854346 cites W2751499104 @default.
- W2965854346 cites W2767438407 @default.
- W2965854346 cites W2809869829 @default.
- W2965854346 cites W2810729068 @default.
- W2965854346 cites W4234116362 @default.
- W2965854346 cites W4366807497 @default.
- W2965854346 doi "https://doi.org/10.1080/21691401.2019.1645157" @default.
- W2965854346 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31352837" @default.
- W2965854346 hasPublicationYear "2019" @default.
- W2965854346 type Work @default.
- W2965854346 sameAs 2965854346 @default.
- W2965854346 citedByCount "3" @default.
- W2965854346 countsByYear W29658543462021 @default.
- W2965854346 countsByYear W29658543462022 @default.
- W2965854346 crossrefType "journal-article" @default.
- W2965854346 hasAuthorship W2965854346A5005406845 @default.
- W2965854346 hasAuthorship W2965854346A5078805860 @default.
- W2965854346 hasBestOaLocation W29658543461 @default.
- W2965854346 hasConcept C161790260 @default.
- W2965854346 hasConcept C178790620 @default.
- W2965854346 hasConcept C185154212 @default.
- W2965854346 hasConcept C185592680 @default.
- W2965854346 hasConcept C26865036 @default.
- W2965854346 hasConcept C2778917026 @default.
- W2965854346 hasConcept C2779191827 @default.
- W2965854346 hasConcept C2780534640 @default.
- W2965854346 hasConcept C55493867 @default.
- W2965854346 hasConcept C65165184 @default.
- W2965854346 hasConcept C71924100 @default.
- W2965854346 hasConcept C98274493 @default.
- W2965854346 hasConceptScore W2965854346C161790260 @default.
- W2965854346 hasConceptScore W2965854346C178790620 @default.
- W2965854346 hasConceptScore W2965854346C185154212 @default.
- W2965854346 hasConceptScore W2965854346C185592680 @default.
- W2965854346 hasConceptScore W2965854346C26865036 @default.
- W2965854346 hasConceptScore W2965854346C2778917026 @default.
- W2965854346 hasConceptScore W2965854346C2779191827 @default.
- W2965854346 hasConceptScore W2965854346C2780534640 @default.
- W2965854346 hasConceptScore W2965854346C55493867 @default.
- W2965854346 hasConceptScore W2965854346C65165184 @default.
- W2965854346 hasConceptScore W2965854346C71924100 @default.
- W2965854346 hasConceptScore W2965854346C98274493 @default.
- W2965854346 hasFunder F4320320912 @default.
- W2965854346 hasFunder F4320321945 @default.
- W2965854346 hasFunder F4320334764 @default.
- W2965854346 hasIssue "1" @default.
- W2965854346 hasLocation W29658543461 @default.
- W2965854346 hasLocation W29658543462 @default.
- W2965854346 hasLocation W29658543463 @default.
- W2965854346 hasOpenAccess W2965854346 @default.
- W2965854346 hasPrimaryLocation W29658543461 @default.
- W2965854346 hasRelatedWork W1517982398 @default.
- W2965854346 hasRelatedWork W1583276795 @default.
- W2965854346 hasRelatedWork W1590927741 @default.
- W2965854346 hasRelatedWork W1865456213 @default.
- W2965854346 hasRelatedWork W1954423156 @default.
- W2965854346 hasRelatedWork W2021458221 @default.
- W2965854346 hasRelatedWork W2067847081 @default.
- W2965854346 hasRelatedWork W2332444587 @default.
- W2965854346 hasRelatedWork W2510370657 @default.
- W2965854346 hasRelatedWork W2793778235 @default.
- W2965854346 hasVolume "47" @default.
- W2965854346 isParatext "false" @default.
- W2965854346 isRetracted "false" @default.
- W2965854346 magId "2965854346" @default.
- W2965854346 workType "article" @default.