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• W2965874780 abstract "T-cell transfer into lymphodepleted recipients induces homeostatic activation and potentiates antitumor efficacy. In contrast to canonical T-cell receptor-induced activation, homeostatic activation yields a distinct phenotype and memory state whose regulatory mechanisms are poorly understood. Here, we show in patients and murine models that, following transfer into lymphodepleted bone marrow transplant (BMT) recipients, CD8+ T cells undergo activation but also simultaneous homeostatic inhibition manifested by upregulation of immune-checkpoint molecules and functional suppression. T cells transferred into BMT recipients were protected from homeostatic inhibition by PD-1/CTLA4 dual checkpoint blockade (dCB). This combination of dCB and BMT-immunotransplant-increased T-cell homeostatic activation and antitumor T-cell responses by an order of magnitude. Like homeostatic activation, homeostatic inhibition is IL7/IL15-dependent, revealing mechanistic coupling of these two processes. Marked similarity in ex vivo modulation of post-BMT T cells in mice and patients is promising for the clinical translation of immunotransplant (NCT03305445) and for addressing homeostatic inhibition in T-cell therapies. SIGNIFICANCE: For optimal anticancer effect, T-cell therapies including chimeric antigen receptor T-cell, tumor-infiltrating lymphocyte, and transgenic T-cell therapies require transfer into lymphodepleted recipients and homeostatic activation; however, concomitant homeostatic inhibition mitigates T-cell therapies' efficacy. Checkpoint blockade uncouples homeostatic inhibition from activation, amplifying T-cell responses. Conversely, tumors nonresponsive to checkpoint blockade or BMT are treatable with immunotransplant.See related commentary by Ansell, p. 1487.This article is highlighted in the In This Issue feature, p. 1469." @default.
• W2965874780 created "2019-08-13" @default.
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• W2965874780 date "2019-11-01" @default.
• W2965874780 modified "2023-09-23" @default.
• W2965874780 title "Antitumor T-cell Homeostatic Activation Is Uncoupled from Homeostatic Inhibition by Checkpoint Blockade" @default.
• W2965874780 cites W1538902372 @default.
• W2965874780 cites W1558376983 @default.
• W2965874780 cites W1584501990 @default.
• W2965874780 cites W1607301590 @default.
• W2965874780 cites W1721778868 @default.
• W2965874780 cites W1963130477 @default.
• W2965874780 cites W1964077677 @default.
• W2965874780 cites W1971902136 @default.
• W2965874780 cites W1974424684 @default.
• W2965874780 cites W1976785514 @default.
• W2965874780 cites W1980920064 @default.
• W2965874780 cites W1983123028 @default.
• W2965874780 cites W1985266927 @default.
• W2965874780 cites W1997130093 @default.
• W2965874780 cites W1997353354 @default.
• W2965874780 cites W2003717645 @default.
• W2965874780 cites W2016789384 @default.
• W2965874780 cites W2018775174 @default.
• W2965874780 cites W2033222990 @default.
• W2965874780 cites W2037610638 @default.
• W2965874780 cites W2038044127 @default.
• W2965874780 cites W2054119257 @default.
• W2965874780 cites W2077116159 @default.
• W2965874780 cites W2086121828 @default.
• W2965874780 cites W2090574161 @default.
• W2965874780 cites W2091734007 @default.
• W2965874780 cites W2094652659 @default.
• W2965874780 cites W2102810679 @default.
• W2965874780 cites W2104966044 @default.
• W2965874780 cites W2107225522 @default.
• W2965874780 cites W2117603772 @default.
• W2965874780 cites W2117926449 @default.
• W2965874780 cites W2124002866 @default.
• W2965874780 cites W2124373740 @default.
• W2965874780 cites W2125075477 @default.
• W2965874780 cites W2125616358 @default.
• W2965874780 cites W2129860342 @default.
• W2965874780 cites W2144129204 @default.
• W2965874780 cites W2149441684 @default.
• W2965874780 cites W2153512326 @default.
• W2965874780 cites W2158393416 @default.
• W2965874780 cites W2158592477 @default.
• W2965874780 cites W2160430737 @default.
• W2965874780 cites W2165463990 @default.
• W2965874780 cites W2265285917 @default.
• W2965874780 cites W2281537211 @default.
• W2965874780 cites W2327639086 @default.
• W2965874780 cites W2341934082 @default.
• W2965874780 cites W2519263052 @default.
• W2965874780 cites W2540499968 @default.
• W2965874780 cites W2559953355 @default.
• W2965874780 cites W2566018578 @default.
• W2965874780 cites W2595802803 @default.
• W2965874780 cites W2605630275 @default.
• W2965874780 cites W2609289346 @default.
• W2965874780 cites W2619188665 @default.
• W2965874780 cites W2652725838 @default.
• W2965874780 cites W2773804840 @default.
• W2965874780 cites W2773920738 @default.
• W2965874780 cites W2777469091 @default.
• W2965874780 cites W2784868445 @default.
• W2965874780 cites W2788425782 @default.
• W2965874780 cites W2791358733 @default.
• W2965874780 cites W2796737118 @default.
• W2965874780 cites W2797675588 @default.
• W2965874780 cites W2898075889 @default.
• W2965874780 cites W2904909560 @default.
• W2965874780 cites W2932616793 @default.
• W2965874780 cites W2938889495 @default.
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• W2965874780 doi "https://doi.org/10.1158/2159-8290.cd-19-0391" @default.
• W2965874780 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6825548" @default.
• W2965874780 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31375522" @default.
• W2965874780 hasPublicationYear "2019" @default.
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