Matches in SemOpenAlex for { <https://semopenalex.org/work/W2965909654> ?p ?o ?g. }
- W2965909654 endingPage "103163" @default.
- W2965909654 startingPage "103163" @default.
- W2965909654 abstract "Curcumin (CUR) is a natural yellow pigment from turmeric with extensive bioactivities. However its relatively poor solubility limited its absorption and bioavailability. In this study, a novel series of CUR-peptide conjugates were designed and synthesized as PepT1-mediated transport drugs and their solubility, cellular uptakes and anti-tumor activities were evaluated. Ten compounds showed better water solubility than CUR due to the dipeptide moiety. Compared with CUR, compound 5e exhibited the slightly better activity and 5d showed the similar activity with CUR. Besides, compounds 5d and 5e performed higher cellular uptakes in Caco-2 cell and dose-dependently inhibited by the addition of PepT1 typical substrate glycylsarcosine (Gly-Sar). Compound 5d and 5e have improved the absorption of CUR by PepT1-mediated without affected the activity. These new dipeptide conjugates of CUR may serve as promising lead compounds for future drug development." @default.
- W2965909654 created "2019-08-13" @default.
- W2965909654 creator A5014971828 @default.
- W2965909654 creator A5034268506 @default.
- W2965909654 creator A5036388641 @default.
- W2965909654 creator A5036608458 @default.
- W2965909654 creator A5043197140 @default.
- W2965909654 creator A5060165452 @default.
- W2965909654 creator A5062067528 @default.
- W2965909654 creator A5067870110 @default.
- W2965909654 date "2019-11-01" @default.
- W2965909654 modified "2023-10-01" @default.
- W2965909654 title "Synthesis and biological evaluation of a novel series of curcumin-peptide derivatives as PepT1-mediated transport drugs" @default.
- W2965909654 cites W1990351531 @default.
- W2965909654 cites W1997149430 @default.
- W2965909654 cites W2010005339 @default.
- W2965909654 cites W2016753008 @default.
- W2965909654 cites W2022963171 @default.
- W2965909654 cites W2023431192 @default.
- W2965909654 cites W2035308484 @default.
- W2965909654 cites W2040377443 @default.
- W2965909654 cites W2061048069 @default.
- W2965909654 cites W2086851668 @default.
- W2965909654 cites W2098049360 @default.
- W2965909654 cites W2107145002 @default.
- W2965909654 cites W2109277581 @default.
- W2965909654 cites W2129333140 @default.
- W2965909654 cites W2143099874 @default.
- W2965909654 cites W2148037580 @default.
- W2965909654 cites W2160770872 @default.
- W2965909654 cites W2326085958 @default.
- W2965909654 cites W2341862559 @default.
- W2965909654 cites W2524578182 @default.
- W2965909654 cites W2571014674 @default.
- W2965909654 cites W2577850892 @default.
- W2965909654 cites W2605816708 @default.
- W2965909654 cites W2752390130 @default.
- W2965909654 cites W2901824796 @default.
- W2965909654 doi "https://doi.org/10.1016/j.bioorg.2019.103163" @default.
- W2965909654 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31450166" @default.
- W2965909654 hasPublicationYear "2019" @default.
- W2965909654 type Work @default.
- W2965909654 sameAs 2965909654 @default.
- W2965909654 citedByCount "5" @default.
- W2965909654 countsByYear W29659096542020 @default.
- W2965909654 countsByYear W29659096542021 @default.
- W2965909654 countsByYear W29659096542023 @default.
- W2965909654 crossrefType "journal-article" @default.
- W2965909654 hasAuthorship W2965909654A5014971828 @default.
- W2965909654 hasAuthorship W2965909654A5034268506 @default.
- W2965909654 hasAuthorship W2965909654A5036388641 @default.
- W2965909654 hasAuthorship W2965909654A5036608458 @default.
- W2965909654 hasAuthorship W2965909654A5043197140 @default.
- W2965909654 hasAuthorship W2965909654A5060165452 @default.
- W2965909654 hasAuthorship W2965909654A5062067528 @default.
- W2965909654 hasAuthorship W2965909654A5067870110 @default.
- W2965909654 hasConcept C121332964 @default.
- W2965909654 hasConcept C125287762 @default.
- W2965909654 hasConcept C155574463 @default.
- W2965909654 hasConcept C178790620 @default.
- W2965909654 hasConcept C181389837 @default.
- W2965909654 hasConcept C185592680 @default.
- W2965909654 hasConcept C202751555 @default.
- W2965909654 hasConcept C21951064 @default.
- W2965909654 hasConcept C24890656 @default.
- W2965909654 hasConcept C2776568683 @default.
- W2965909654 hasConcept C2777752112 @default.
- W2965909654 hasConcept C2778250585 @default.
- W2965909654 hasConcept C2779138802 @default.
- W2965909654 hasConcept C2779281246 @default.
- W2965909654 hasConcept C2780035454 @default.
- W2965909654 hasConcept C55493867 @default.
- W2965909654 hasConcept C71240020 @default.
- W2965909654 hasConcept C71924100 @default.
- W2965909654 hasConcept C98274493 @default.
- W2965909654 hasConceptScore W2965909654C121332964 @default.
- W2965909654 hasConceptScore W2965909654C125287762 @default.
- W2965909654 hasConceptScore W2965909654C155574463 @default.
- W2965909654 hasConceptScore W2965909654C178790620 @default.
- W2965909654 hasConceptScore W2965909654C181389837 @default.
- W2965909654 hasConceptScore W2965909654C185592680 @default.
- W2965909654 hasConceptScore W2965909654C202751555 @default.
- W2965909654 hasConceptScore W2965909654C21951064 @default.
- W2965909654 hasConceptScore W2965909654C24890656 @default.
- W2965909654 hasConceptScore W2965909654C2776568683 @default.
- W2965909654 hasConceptScore W2965909654C2777752112 @default.
- W2965909654 hasConceptScore W2965909654C2778250585 @default.
- W2965909654 hasConceptScore W2965909654C2779138802 @default.
- W2965909654 hasConceptScore W2965909654C2779281246 @default.
- W2965909654 hasConceptScore W2965909654C2780035454 @default.
- W2965909654 hasConceptScore W2965909654C55493867 @default.
- W2965909654 hasConceptScore W2965909654C71240020 @default.
- W2965909654 hasConceptScore W2965909654C71924100 @default.
- W2965909654 hasConceptScore W2965909654C98274493 @default.
- W2965909654 hasFunder F4320321001 @default.
- W2965909654 hasLocation W29659096541 @default.
- W2965909654 hasLocation W29659096542 @default.
- W2965909654 hasOpenAccess W2965909654 @default.