FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2966007344> ?p ?o ?g. }

• W2966007344 abstract "Age-related hearing loss (ARHL) is a major neurodegenerative disorder and the leading cause of communication deficit in the elderly population, which remains largely untreated. The development of ARHL is a multifactorial event that includes both intrinsic and extrinsic factors. Recent studies suggest that NAD+ /NADH ratio may play a critical role in cellular senescence by regulating sirtuins, PARP-1, and PGC-1α. Nonetheless, the beneficial effect of direct modulation of cellular NAD+ levels on aging and age-related diseases has not been studied, and the underlying mechanisms remain obscure. Herein, we investigated the effect of β-lapachone (β-lap), a known plant-derived metabolite that modulates cellular NAD+ by conversion of NADH to NAD+ via the enzymatic action of NADH: quinone oxidoreductase 1 (NQO1) on ARHL in C57BL/6 mice. We elucidated that the reduction of cellular NAD+ during the aging process was an important contributor for ARHL; it facilitated oxidative stress and pro-inflammatory responses in the cochlear tissue through regulating sirtuins that alter various signaling pathways, such as NF-κB, p53, and IDH2. However, augmentation of NAD+ by β-lap effectively prevented ARHL and accompanying deleterious effects through reducing inflammation and oxidative stress, sustaining mitochondrial function, and promoting mitochondrial biogenesis in rodents. These results suggest that direct regulation of cellular NAD+ levels by pharmacological agents may be a tangible therapeutic option for treating various age-related diseases, including ARHL." @default.
• W2966007344 created "2019-08-13" @default.
• W2966007344 creator A5007640483 @default.
• W2966007344 creator A5011107013 @default.
• W2966007344 creator A5011116102 @default.
• W2966007344 creator A5016654547 @default.
• W2966007344 creator A5027294627 @default.
• W2966007344 creator A5033045616 @default.
• W2966007344 creator A5041508602 @default.
• W2966007344 creator A5046904128 @default.
• W2966007344 creator A5050841050 @default.
• W2966007344 creator A5050853149 @default.
• W2966007344 creator A5063907469 @default.
• W2966007344 creator A5065182181 @default.
• W2966007344 creator A5068403098 @default.
• W2966007344 creator A5069298406 @default.
• W2966007344 date "2019-07-28" @default.
• W2966007344 modified "2023-10-16" @default.
• W2966007344 title "Augmentation of cellular NAD⁺ by NQO1 enzymatic action improves age‐related hearing impairment" @default.
• W2966007344 cites W1232215139 @default.
• W2966007344 cites W1482836988 @default.
• W2966007344 cites W1964876127 @default.
• W2966007344 cites W1970060454 @default.
• W2966007344 cites W1970554352 @default.
• W2966007344 cites W1975964850 @default.
• W2966007344 cites W1988877971 @default.
• W2966007344 cites W2001686534 @default.
• W2966007344 cites W2006086532 @default.
• W2966007344 cites W2013841882 @default.
• W2966007344 cites W2014705874 @default.
• W2966007344 cites W2020304127 @default.
• W2966007344 cites W2023380668 @default.
• W2966007344 cites W2024783145 @default.
• W2966007344 cites W2027029724 @default.
• W2966007344 cites W2046207757 @default.
• W2966007344 cites W2052080274 @default.
• W2966007344 cites W2053594100 @default.
• W2966007344 cites W2055208928 @default.
• W2966007344 cites W2068342708 @default.
• W2966007344 cites W2070765029 @default.
• W2966007344 cites W2071773362 @default.
• W2966007344 cites W2071850731 @default.
• W2966007344 cites W2083743765 @default.
• W2966007344 cites W2090442368 @default.
• W2966007344 cites W2091008007 @default.
• W2966007344 cites W2092658747 @default.
• W2966007344 cites W2098343475 @default.
• W2966007344 cites W2108103966 @default.
• W2966007344 cites W2120310638 @default.
• W2966007344 cites W2132169664 @default.
• W2966007344 cites W2140751228 @default.
• W2966007344 cites W2140925956 @default.
• W2966007344 cites W2141438496 @default.
• W2966007344 cites W2145211974 @default.
• W2966007344 cites W2150875293 @default.
• W2966007344 cites W2151213561 @default.
• W2966007344 cites W2161018659 @default.
• W2966007344 cites W2318397082 @default.
• W2966007344 cites W2327783429 @default.
• W2966007344 cites W2344682763 @default.
• W2966007344 cites W2366890695 @default.
• W2966007344 cites W2605627321 @default.
• W2966007344 cites W2744242723 @default.
• W2966007344 cites W2763516532 @default.
• W2966007344 cites W2791789208 @default.
• W2966007344 cites W2887456182 @default.
• W2966007344 cites W2899505251 @default.
• W2966007344 cites W2966007344 @default.
• W2966007344 doi "https://doi.org/10.1111/acel.13016" @default.
• W2966007344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6718544" @default.
• W2966007344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31353811" @default.
• W2966007344 hasPublicationYear "2019" @default.
• W2966007344 type Work @default.
• W2966007344 sameAs 2966007344 @default.
• W2966007344 citedByCount "17" @default.
• W2966007344 countsByYear W29660073442019 @default.
• W2966007344 countsByYear W29660073442020 @default.
• W2966007344 countsByYear W29660073442021 @default.
• W2966007344 countsByYear W29660073442022 @default.
• W2966007344 countsByYear W29660073442023 @default.
• W2966007344 crossrefType "journal-article" @default.
• W2966007344 hasAuthorship W2966007344A5007640483 @default.
• W2966007344 hasAuthorship W2966007344A5011107013 @default.
• W2966007344 hasAuthorship W2966007344A5011116102 @default.
• W2966007344 hasAuthorship W2966007344A5016654547 @default.
• W2966007344 hasAuthorship W2966007344A5027294627 @default.
• W2966007344 hasAuthorship W2966007344A5033045616 @default.
• W2966007344 hasAuthorship W2966007344A5041508602 @default.
• W2966007344 hasAuthorship W2966007344A5046904128 @default.
• W2966007344 hasAuthorship W2966007344A5050841050 @default.
• W2966007344 hasAuthorship W2966007344A5050853149 @default.
• W2966007344 hasAuthorship W2966007344A5063907469 @default.
• W2966007344 hasAuthorship W2966007344A5065182181 @default.
• W2966007344 hasAuthorship W2966007344A5068403098 @default.
• W2966007344 hasAuthorship W2966007344A5069298406 @default.
• W2966007344 hasBestOaLocation W29660073441 @default.
• W2966007344 hasConcept C104317684 @default.
• W2966007344 hasConcept C127561419 @default.
• W2966007344 hasConcept C181199279 @default.
• W2966007344 hasConcept C2776151105 @default.

• next