FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2966014566> ?p ?o ?g. }

• W2966014566 endingPage "700" @default.
• W2966014566 startingPage "693" @default.
• W2966014566 abstract "Abstract Background Malaria control efforts in Sudan rely heavily on case management. In 2004, health authorities adopted artemisinin-based combination therapies (ACTs) for the treatment of uncomplicated malaria. However, some recent surveys have reported ACT failure and a prevalent irrational malaria treatment practice. Here we examine whether the widespread use of ACT and failure to adhere to national guidelines have led to the evolution of drug resistance genes. Methods We genotyped known drug resistance markers (Pfcrt, Pfmdr-1, Pfdhfr, Pfdhps, Pfk13 propeller) and their flanking microsatellites among Plasmodium falciparum isolates obtained between 2009 and 2016 in different geographical regions in Sudan. Data were then compared with published findings pre-ACT (1992–2003). Results A high prevalence of Pfcrt76T, Pfmdr-1-86Y, Pfdhfr51I, Pfdhfr108N, Pfdhps37G was observed in all regions, while no Pfk13 mutations were detected. Compared with pre-ACT data, Pfcrt-76T and Pfmdr-1-86Y have decayed, while Pfdhfr-51I, Pfdhfr-108N and Pfdhps-437G strengthened. Haplotypes Pfcrt-CVIET, Pfmdr-1-NFSND/YFSND, Pfdhfr-ICNI and Pfdhps-SGKAA predominated in all sites. Microsatellites flanking drug resistance genes showed lower diversity than neutral ones, signifying high ACT pressure/selection. Conclusions Evaluation of P. falciparum drug resistance genes in Sudan matches the drug deployment pattern. Regular monitoring of these genes, coupled with clinical response, should be considered to combat the spread of ACT resistance." @default.
• W2966014566 created "2019-08-13" @default.
• W2966014566 creator A5009499607 @default.
• W2966014566 creator A5037758591 @default.
• W2966014566 creator A5038439031 @default.
• W2966014566 creator A5038538084 @default.
• W2966014566 creator A5040271212 @default.
• W2966014566 creator A5045690795 @default.
• W2966014566 creator A5047191357 @default.
• W2966014566 creator A5048792451 @default.
• W2966014566 creator A5063189851 @default.
• W2966014566 creator A5070745816 @default.
• W2966014566 creator A5075493341 @default.
• W2966014566 creator A5079901880 @default.
• W2966014566 creator A5080281130 @default.
• W2966014566 creator A5082419997 @default.
• W2966014566 creator A5089381738 @default.
• W2966014566 date "2019-08-01" @default.
• W2966014566 modified "2023-10-17" @default.
• W2966014566 title "Evolution of Plasmodium falciparum drug resistance genes following artemisinin combination therapy in Sudan" @default.
• W2966014566 cites W1964485164 @default.
• W2966014566 cites W1969571661 @default.
• W2966014566 cites W1972177048 @default.
• W2966014566 cites W1984669077 @default.
• W2966014566 cites W1989674671 @default.
• W2966014566 cites W1997543935 @default.
• W2966014566 cites W1997846666 @default.
• W2966014566 cites W1999520041 @default.
• W2966014566 cites W2009021681 @default.
• W2966014566 cites W2020902855 @default.
• W2966014566 cites W2041345047 @default.
• W2966014566 cites W2067969604 @default.
• W2966014566 cites W2072414151 @default.
• W2966014566 cites W2076050649 @default.
• W2966014566 cites W2090438527 @default.
• W2966014566 cites W2091586468 @default.
• W2966014566 cites W2095182829 @default.
• W2966014566 cites W2099198335 @default.
• W2966014566 cites W2108159011 @default.
• W2966014566 cites W2112261944 @default.
• W2966014566 cites W2113950932 @default.
• W2966014566 cites W2124634096 @default.
• W2966014566 cites W2129965217 @default.
• W2966014566 cites W2137451577 @default.
• W2966014566 cites W2142060065 @default.
• W2966014566 cites W2142995308 @default.
• W2966014566 cites W2155812069 @default.
• W2966014566 cites W2155890819 @default.
• W2966014566 cites W2162056783 @default.
• W2966014566 cites W2162629756 @default.
• W2966014566 cites W2163765308 @default.
• W2966014566 cites W2170874271 @default.
• W2966014566 cites W2398110767 @default.
• W2966014566 cites W2605400261 @default.
• W2966014566 cites W2752610535 @default.
• W2966014566 doi "https://doi.org/10.1093/trstmh/trz059" @default.
• W2966014566 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31369106" @default.
• W2966014566 hasPublicationYear "2019" @default.
• W2966014566 type Work @default.
• W2966014566 sameAs 2966014566 @default.
• W2966014566 citedByCount "13" @default.
• W2966014566 countsByYear W29660145662019 @default.
• W2966014566 countsByYear W29660145662020 @default.
• W2966014566 countsByYear W29660145662021 @default.
• W2966014566 countsByYear W29660145662022 @default.
• W2966014566 countsByYear W29660145662023 @default.
• W2966014566 crossrefType "journal-article" @default.
• W2966014566 hasAuthorship W2966014566A5009499607 @default.
• W2966014566 hasAuthorship W2966014566A5037758591 @default.
• W2966014566 hasAuthorship W2966014566A5038439031 @default.
• W2966014566 hasAuthorship W2966014566A5038538084 @default.
• W2966014566 hasAuthorship W2966014566A5040271212 @default.
• W2966014566 hasAuthorship W2966014566A5045690795 @default.
• W2966014566 hasAuthorship W2966014566A5047191357 @default.
• W2966014566 hasAuthorship W2966014566A5048792451 @default.
• W2966014566 hasAuthorship W2966014566A5063189851 @default.
• W2966014566 hasAuthorship W2966014566A5070745816 @default.
• W2966014566 hasAuthorship W2966014566A5075493341 @default.
• W2966014566 hasAuthorship W2966014566A5079901880 @default.
• W2966014566 hasAuthorship W2966014566A5080281130 @default.
• W2966014566 hasAuthorship W2966014566A5082419997 @default.
• W2966014566 hasAuthorship W2966014566A5089381738 @default.
• W2966014566 hasConcept C114851261 @default.
• W2966014566 hasConcept C159047783 @default.
• W2966014566 hasConcept C203014093 @default.
• W2966014566 hasConcept C2776120307 @default.
• W2966014566 hasConcept C2778048844 @default.
• W2966014566 hasConcept C2778371730 @default.
• W2966014566 hasConcept C54355233 @default.
• W2966014566 hasConcept C71924100 @default.
• W2966014566 hasConcept C86803240 @default.
• W2966014566 hasConceptScore W2966014566C114851261 @default.
• W2966014566 hasConceptScore W2966014566C159047783 @default.
• W2966014566 hasConceptScore W2966014566C203014093 @default.
• W2966014566 hasConceptScore W2966014566C2776120307 @default.
• W2966014566 hasConceptScore W2966014566C2778048844 @default.
• W2966014566 hasConceptScore W2966014566C2778371730 @default.
• W2966014566 hasConceptScore W2966014566C54355233 @default.

• next