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• W2966025140 abstract "Abstract Defects in flagella/cilia are often associated with infertility and disease. Motile male gametes (sperm cells) with flagella are an ancestral eukaryotic trait that has been lost in several lineages, for example in flowering plants. Here, we made use of a phenotypic male fertility difference between two moss ( Physcomitrella patens ) strains to explore spermatozoid function. We compare genetic and epigenetic variation as well as expression profiles between the Gransden and Reute strain to identify a set of genes associated with moss male infertility. Defects in mammal and algal homologs of these genes coincide with a loss of fertility, demonstrating the evolutionary conservation of flagellar function related to male fertility across kingdoms. As a proof of principle, we generated a loss-of-function mutant of a coiled-coil domain containing 39 (ccdc39) gene that is part of the flagellar hydin network. Indeed, the Ppccdc39 mutant resembles the male infertile Gransden strain phenotype. Potentially, several somatic (epi-)mutations occurred during prolonged vegetative propagation of P. patens Gransden, causing regulatory differences of e.g. the homeodomain transcription factor BELL1. Probably these somatic changes are causative for the observed male fertility. We propose that P. patens spermatozoids might be employed as an easily accessible system to study male infertility of human and animals." @default.
• W2966025140 created "2019-08-13" @default.
• W2966025140 creator A5014974142 @default.
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• W2966025140 date "2019-08-08" @default.
• W2966025140 modified "2023-09-26" @default.
• W2966025140 title "Characterization of evolutionarily conserved key players affecting eukaryotic flagellar motility and fertility using a moss model" @default.
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• W2966025140 cites W1992457710 @default.
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• W2966025140 doi "https://doi.org/10.1101/728691" @default.
• W2966025140 hasPublicationYear "2019" @default.
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