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- W2966041158 abstract "Particulate matter (PM) exposure has become one of the most serious problems. The aim of the present study was to evaluate the hair cell damage and possible developmental toxicity caused by PM 2.5 exposure using a zebrafish model. Zebrafish embryos were exposed to various concentrations of PM 2.5. Developmental toxicity was evaluated based on general morphology score (GMS) system and Panzica-Kelly score, and by measurement of body length and heart rate. To evaluate hair cell damage, the average number of total hair cells within four neuromasts exposed to various concentrations of PM 2.5 was compared with that of the control group. Morphological abnormalities evaluated by the GMS system and Panzica-Kelly score were rare and body length tended to be shorter in the PM 2.5 -exposed groups. Heart rate decreased significantly in the PM 2.5 -exposed group. Additionally, significant hair cell damage was observed after PM 2.5 exposure. It was dose-dependent and more severe after a longer period exposure (10 dpf). In zebrafish embryos, exposure of PM 2.5 in the early stages of life decreased heart rate and caused significant hair cell damage in a dose-dependent manner." @default.
- W2966041158 created "2019-08-13" @default.
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- W2966041158 date "2019-11-01" @default.
- W2966041158 modified "2023-09-24" @default.
- W2966041158 title "Assessment of hair cell damage and developmental toxicity after fine particulate matter 2.5 μm (PM 2.5) exposure using zebrafish (Danio rerio) models" @default.
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- W2966041158 doi "https://doi.org/10.1016/j.ijporl.2019.109611" @default.
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