FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2966057325> ?p ?o ?g. }

• W2966057325 endingPage "001841" @default.
• W2966057325 startingPage "ejhpharm" @default.
• W2966057325 abstract "It is often difficult to relieve the pain from skin ulcers. In several patients, topical morphine, applied as a hydrogel, has been described as useful. There is no such product commercially available. We present a solution for compounding, packaging, sterilisation and chemical stability of a morphine containing hydrogel.We developed a morphine containing poloxamer 407 thermoreversible hydrogel with a concentration of 5 mg/g (0.5% w/w) morphine hydrochloride. The hydrogel was packaged into a plastic prefillable syringe system: BD Sterifill SCF. This syringe can be steam sterilised after it has been filled.Sterility tests according to the European Pharmacopoeia showed the product to be sterile directly after production and sterilisation and after 20 months of storage. The stability of the morphine hydrochloride was assessed by monthly analysis of the concentration with a stability indicating HPLC-UV method. Morphine hydrochloride concentrations remained between 90% and 110% of the theoretical concentration for a period of 36 months, when stored at room temperature outside the influence of light.With the described formulation, packaging, sterilisation and stability data, together with the previously reported biopharmaceutical dissolution profile, we present a complete solution for a morphine containing poloxamer 407 hydrogel that can be compounded in any pharmacy with a steam or hot water steriliser at their disposal. This might improve the availability of a sterile morphine hydrogel for the treatment of painful skin ulcers." @default.
• W2966057325 created "2019-08-13" @default.
• W2966057325 creator A5021568119 @default.
• W2966057325 creator A5021602634 @default.
• W2966057325 creator A5022935659 @default.
• W2966057325 creator A5036764484 @default.
• W2966057325 date "2019-07-29" @default.
• W2966057325 modified "2023-09-23" @default.
• W2966057325 title "Development of a sterile morphine hydrogel for the local treatment of painful skin ulcers" @default.
• W2966057325 cites W143062720 @default.
• W2966057325 cites W1591110681 @default.
• W2966057325 cites W1963627122 @default.
• W2966057325 cites W1969604041 @default.
• W2966057325 cites W1971380480 @default.
• W2966057325 cites W1981723645 @default.
• W2966057325 cites W1992661026 @default.
• W2966057325 cites W1994713846 @default.
• W2966057325 cites W1995131423 @default.
• W2966057325 cites W1996002872 @default.
• W2966057325 cites W2001495702 @default.
• W2966057325 cites W2010112920 @default.
• W2966057325 cites W2024402949 @default.
• W2966057325 cites W2028699573 @default.
• W2966057325 cites W2034056629 @default.
• W2966057325 cites W2052033071 @default.
• W2966057325 cites W2054294783 @default.
• W2966057325 cites W2056330967 @default.
• W2966057325 cites W2061502387 @default.
• W2966057325 cites W2102412754 @default.
• W2966057325 cites W2110791210 @default.
• W2966057325 cites W2125595203 @default.
• W2966057325 cites W2127368191 @default.
• W2966057325 cites W2336886634 @default.
• W2966057325 cites W2395398941 @default.
• W2966057325 cites W2411902211 @default.
• W2966057325 doi "https://doi.org/10.1136/ejhpharm-2018-001841" @default.
• W2966057325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8552166" @default.
• W2966057325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34697049" @default.
• W2966057325 hasPublicationYear "2019" @default.
• W2966057325 type Work @default.
• W2966057325 sameAs 2966057325 @default.
• W2966057325 citedByCount "0" @default.
• W2966057325 crossrefType "journal-article" @default.
• W2966057325 hasAuthorship W2966057325A5021568119 @default.
• W2966057325 hasAuthorship W2966057325A5021602634 @default.
• W2966057325 hasAuthorship W2966057325A5022935659 @default.
• W2966057325 hasAuthorship W2966057325A5036764484 @default.
• W2966057325 hasBestOaLocation W29660573252 @default.
• W2966057325 hasConcept C101335993 @default.
• W2966057325 hasConcept C118552586 @default.
• W2966057325 hasConcept C141071460 @default.
• W2966057325 hasConcept C15920480 @default.
• W2966057325 hasConcept C178790620 @default.
• W2966057325 hasConcept C185592680 @default.
• W2966057325 hasConcept C207673951 @default.
• W2966057325 hasConcept C2777389121 @default.
• W2966057325 hasConcept C2778571141 @default.
• W2966057325 hasConcept C3019474993 @default.
• W2966057325 hasConcept C31903555 @default.
• W2966057325 hasConcept C42219234 @default.
• W2966057325 hasConcept C43617362 @default.
• W2966057325 hasConcept C521977710 @default.
• W2966057325 hasConcept C71924100 @default.
• W2966057325 hasConcept C98274493 @default.
• W2966057325 hasConceptScore W2966057325C101335993 @default.
• W2966057325 hasConceptScore W2966057325C118552586 @default.
• W2966057325 hasConceptScore W2966057325C141071460 @default.
• W2966057325 hasConceptScore W2966057325C15920480 @default.
• W2966057325 hasConceptScore W2966057325C178790620 @default.
• W2966057325 hasConceptScore W2966057325C185592680 @default.
• W2966057325 hasConceptScore W2966057325C207673951 @default.
• W2966057325 hasConceptScore W2966057325C2777389121 @default.
• W2966057325 hasConceptScore W2966057325C2778571141 @default.
• W2966057325 hasConceptScore W2966057325C3019474993 @default.
• W2966057325 hasConceptScore W2966057325C31903555 @default.
• W2966057325 hasConceptScore W2966057325C42219234 @default.
• W2966057325 hasConceptScore W2966057325C43617362 @default.
• W2966057325 hasConceptScore W2966057325C521977710 @default.
• W2966057325 hasConceptScore W2966057325C71924100 @default.
• W2966057325 hasConceptScore W2966057325C98274493 @default.
• W2966057325 hasLocation W29660573251 @default.
• W2966057325 hasLocation W29660573252 @default.
• W2966057325 hasLocation W29660573253 @default.
• W2966057325 hasOpenAccess W2966057325 @default.
• W2966057325 hasPrimaryLocation W29660573251 @default.
• W2966057325 hasRelatedWork W2003938723 @default.
• W2966057325 hasRelatedWork W2047967234 @default.
• W2966057325 hasRelatedWork W2118496982 @default.
• W2966057325 hasRelatedWork W2179418560 @default.
• W2966057325 hasRelatedWork W2439875401 @default.
• W2966057325 hasRelatedWork W2748952813 @default.
• W2966057325 hasRelatedWork W2899084033 @default.
• W2966057325 hasRelatedWork W2966057325 @default.
• W2966057325 hasRelatedWork W4238867864 @default.
• W2966057325 hasRelatedWork W2525756941 @default.
• W2966057325 isParatext "false" @default.
• W2966057325 isRetracted "false" @default.
• W2966057325 magId "2966057325" @default.

• next