Matches in SemOpenAlex for { <https://semopenalex.org/work/W2966064480> ?p ?o ?g. }
- W2966064480 abstract "Abstract During development, gene regulatory networks allocate cell fates by partitioning tissues into spatially organised domains of gene expression. How the sharp boundaries that delineate these gene expression patterns arise, despite the stochasticity associated with gene regulation, is poorly understood. We show, in the vertebrate neural tube, using perturbations of coding and regulatory regions, that the structure of the regulatory network contributes to boundary precision. This is achieved, not by reducing noise in individual genes, but by the configuration of the network modulating the ability of stochastic fluctuations to initiate gene expression changes. We use a computational screen to identify network properties that influence boundary precision, revealing two dynamical mechanisms by which small gene circuits attenuate the effect of noise in order to increase patterning precision. These results highlight design principles of gene regulatory networks that produce precise patterns of gene expression." @default.
- W2966064480 created "2019-08-13" @default.
- W2966064480 creator A5003676417 @default.
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- W2966064480 creator A5069770227 @default.
- W2966064480 creator A5082823276 @default.
- W2966064480 date "2019-07-31" @default.
- W2966064480 modified "2023-10-18" @default.
- W2966064480 title "Precision of Tissue Patterning is Controlled by Dynamical Properties of Gene Regulatory Networks" @default.
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