Matches in SemOpenAlex for { <https://semopenalex.org/work/W2966107834> ?p ?o ?g. }
- W2966107834 abstract "Abstract Tissue macrophages and tissue resident memory CD8 + T cells (T RM ) play important roles for pathogen sensing and rapid protection of barrier tissues. To date, it is incompletely understood how these two cell types cooperate for efficient organ surveillance during homeostasis. Here, we used intravital imaging to show that T RM dynamically crawled along tissue macrophages in murine submandibular salivary glands (SMG) during the memory phase following a viral infection. Ex vivo confined SMG T RM integrated an unexpectedly wide range of migration modes: in addition to chemokine-and adhesion receptor-driven motility, SMG T RM displayed a remarkable capacity of autonomous motility in the absence of chemoattractants and adhesive ligands. This unique intrinsic SMG T RM motility was transmitted by friction and adaptation to microenvironmental topography through protrusion insertion into permissive gaps. Analysis of extracellular space in SMG using super-resolution shadow imaging showed discontinuous attachment of tissue macrophages to neighboring epithelial cells, offering paths of least resistance for patrolling T RM . Upon tissue macrophage depletion, intraepithelial SMG T RM showed decreased motility and reduced epithelial crossing events, and failed to cluster in response to local inflammatory chemokine stimuli. In sum, our data uncover a continuum of SMG T RM migration modes and identify a new accessory function of tissue macrophages to facilitate T RM patrolling of the complex exocrine gland architecture. One sentence summary Combined in vitro and in vivo imaging of salivary gland-resident tissue memory CD8 + T cells (T RM ) uncovers their unique migratory behavior and describes a novel accessory function of tissue macrophages to assist T RM surveillance." @default.
- W2966107834 created "2019-08-13" @default.
- W2966107834 creator A5000097098 @default.
- W2966107834 creator A5002441112 @default.
- W2966107834 creator A5002959610 @default.
- W2966107834 creator A5007920797 @default.
- W2966107834 creator A5011493742 @default.
- W2966107834 creator A5026734803 @default.
- W2966107834 creator A5027795521 @default.
- W2966107834 creator A5037201565 @default.
- W2966107834 creator A5037898880 @default.
- W2966107834 creator A5042617077 @default.
- W2966107834 creator A5049338002 @default.
- W2966107834 creator A5049408391 @default.
- W2966107834 creator A5063874583 @default.
- W2966107834 creator A5064820640 @default.
- W2966107834 creator A5068299150 @default.
- W2966107834 creator A5074794983 @default.
- W2966107834 creator A5075389746 @default.
- W2966107834 creator A5075445944 @default.
- W2966107834 creator A5075973380 @default.
- W2966107834 creator A5083042012 @default.
- W2966107834 creator A5084119660 @default.
- W2966107834 date "2019-08-05" @default.
- W2966107834 modified "2023-09-27" @default.
- W2966107834 title "Salivary gland macrophages assist tissue-resident CD8+ T cell immune surveillance" @default.
- W2966107834 cites W1428077152 @default.
- W2966107834 cites W1581039134 @default.
- W2966107834 cites W1632859538 @default.
- W2966107834 cites W1664076455 @default.
- W2966107834 cites W1826726928 @default.
- W2966107834 cites W1879385800 @default.
- W2966107834 cites W1910392772 @default.
- W2966107834 cites W1936094671 @default.
- W2966107834 cites W1959677146 @default.
- W2966107834 cites W1971197010 @default.
- W2966107834 cites W1972170345 @default.
- W2966107834 cites W1975112572 @default.
- W2966107834 cites W1978574683 @default.
- W2966107834 cites W1978721833 @default.
- W2966107834 cites W1984474513 @default.
- W2966107834 cites W1998404540 @default.
- W2966107834 cites W1999190426 @default.
- W2966107834 cites W2002715024 @default.
- W2966107834 cites W2007988618 @default.
- W2966107834 cites W2018903405 @default.
- W2966107834 cites W2019922483 @default.
- W2966107834 cites W2021275556 @default.
- W2966107834 cites W2027892036 @default.
- W2966107834 cites W2028192767 @default.
- W2966107834 cites W2033320607 @default.
- W2966107834 cites W2035538295 @default.
- W2966107834 cites W2048175444 @default.
- W2966107834 cites W2053199336 @default.
- W2966107834 cites W2053942778 @default.
- W2966107834 cites W2054286408 @default.
- W2966107834 cites W2054540776 @default.
- W2966107834 cites W2055348159 @default.
- W2966107834 cites W2055620105 @default.
- W2966107834 cites W2057271096 @default.
- W2966107834 cites W2059033421 @default.
- W2966107834 cites W2059654418 @default.
- W2966107834 cites W2066572646 @default.
- W2966107834 cites W2074161152 @default.
- W2966107834 cites W2082103058 @default.
- W2966107834 cites W2083065256 @default.
- W2966107834 cites W2092997355 @default.
- W2966107834 cites W2110344693 @default.
- W2966107834 cites W2113628320 @default.
- W2966107834 cites W2124319877 @default.
- W2966107834 cites W2126374805 @default.
- W2966107834 cites W2136188258 @default.
- W2966107834 cites W2138853264 @default.
- W2966107834 cites W2140368190 @default.
- W2966107834 cites W2145007980 @default.
- W2966107834 cites W2150992850 @default.
- W2966107834 cites W2152074271 @default.
- W2966107834 cites W2153960708 @default.
- W2966107834 cites W2163215955 @default.
- W2966107834 cites W2166769371 @default.
- W2966107834 cites W2171844613 @default.
- W2966107834 cites W2176134716 @default.
- W2966107834 cites W2248463412 @default.
- W2966107834 cites W2252348008 @default.
- W2966107834 cites W2304850680 @default.
- W2966107834 cites W2317145780 @default.
- W2966107834 cites W2507874705 @default.
- W2966107834 cites W2543402640 @default.
- W2966107834 cites W2583762284 @default.
- W2966107834 cites W2586637063 @default.
- W2966107834 cites W2605696370 @default.
- W2966107834 cites W2613553789 @default.
- W2966107834 cites W2625239024 @default.
- W2966107834 cites W2672444148 @default.
- W2966107834 cites W2752914414 @default.
- W2966107834 cites W2789008353 @default.
- W2966107834 cites W2800061482 @default.
- W2966107834 cites W2931582083 @default.
- W2966107834 cites W2932327961 @default.
- W2966107834 cites W4234394063 @default.