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- W2966246830 endingPage "13230" @default.
- W2966246830 startingPage "13218" @default.
- W2966246830 abstract "The present study investigated the effects of iron, iron chelators, and mutations of tonB or iroN fepA genes on the growth and virulence of Salmonella Typhimurium. Results indicated that organic iron (ferric citrate and ferrous-l-ascorbate) supported better growth of Salmonella compared to inorganic iron. Among tested chelators, 2,2'-bipyridyl at 500 μM showed the highest inhibition of Salmonella growth with 5 μM ferrous sulfate. Deletion of genes (tonB- and iroN- fepA- ) in the iron uptake system attenuated Salmonella invasion of Caco-2 cells and its ability to damage the epithelial monolayer. The expression of all tested host genes in Caco-2 was not affected under the iron-poor condition. However, claudin 3, tight junction protein 1, tumor necrosis factor α (TNF-α), and interleukin-8 (IL-8) were altered under the iron-rich condition depending on individual mutations. In Caenorhabditis elegans, a significant down-regulation of ferritin 1 expression was observed when the nematode was infected by the wild-type (WT) strain." @default.
- W2966246830 created "2019-08-13" @default.
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- W2966246830 date "2019-08-07" @default.
- W2966246830 modified "2023-10-16" @default.
- W2966246830 title "Growth and Virulence of <i>Salmonella</i> Typhimurium Mutants Deficient in Iron Uptake" @default.
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- W2966246830 doi "https://doi.org/10.1021/acsomega.9b01367" @default.
- W2966246830 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6705229" @default.
- W2966246830 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/31460449" @default.
- W2966246830 hasPublicationYear "2019" @default.
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